Effect of Trendelenburg Positioning on Anesthesia-Induced Hypotension in Elderly Patients

NCT ID: NCT06968091

Last Updated: 2025-06-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

168 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-05-16

Study Completion Date

2025-12-31

Brief Summary

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This study investigated the effect of Trendelenburg position on preventing post-induction hypotension in elderly patients undergoing abdominal surgery with general anesthesia. The patients will receive the 10° Trendelenburg position or supine position during anesthesia induction. The primary outcome is the area under a mean arterial pressure (MAP) below 65 mm Hg within the first 15 minutes during anesthesia induction.

Detailed Description

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Conditions

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Hypotension on Induction Old Age

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Participants Outcome Assessors
The anesthesiologists do not implement the blinding method for the patient grouping, while the physicians conducting the postoperative follow-up implement the blinding method for the grouping.

Study Groups

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The Trendelenburg Position Group

Group Type EXPERIMENTAL

Trendelenburg position

Intervention Type OTHER

After the loss of consciousness during general anesthesia, the 10° Trendelenburg position is adopted.

The Supine Horizontal Position Group

Group Type PLACEBO_COMPARATOR

Supine Horizontal Position

Intervention Type OTHER

After the loss of consciousness during general anesthesia, the Supine Horizontal Position is adopted.

Interventions

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Trendelenburg position

After the loss of consciousness during general anesthesia, the 10° Trendelenburg position is adopted.

Intervention Type OTHER

Supine Horizontal Position

After the loss of consciousness during general anesthesia, the Supine Horizontal Position is adopted.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* patients aged 65-90 years
* scheduled for abdominal surgery with general anesthesia
* expected to have continuous radial arterial pressure monitoring
* American Society of Anesthesiologists (ASA) physical status I to III

Exclusion Criteria

* contraindications or failure of radial arterial catheterization
* expected possible difficult airway
* non-sinus rhythm
* increased intracranial pressure
* patients at high risk of regurgitation or aspiration
* inability to provide consent
Minimum Eligible Age

65 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Zhejiang Cancer Hospital

OTHER

Sponsor Role lead

Responsible Party

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Gu Bin

Clinical Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Zhejiang cancer hospital

Hangzhou, Zhejiang, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Ji Zhu

Role: CONTACT

057188122146

Other Identifiers

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IRB-2025-478

Identifier Type: -

Identifier Source: org_study_id

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