Respiratory Virus Infections in Acute Heart Failure

NCT ID: NCT06967441

Last Updated: 2025-05-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

360 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-04-07

Study Completion Date

2028-12-31

Brief Summary

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Patients admitted to the cardiology department with acute heart failure who have a nasopharyngeal respiratory virus PCR test performed within 72 hours of admission will be enrolled in the study cohort.

The detection rate of respiratory viruses including influenza virus, RSV, and coronavirus will be analysed. The investigators will also look for seasonal changes in the frequency of respiratory viruses and differences in the clinical presentation of heart failure based on respiratory virus infection.

Detailed Description

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Conditions

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Acute Heart Failure Syndrome

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Adult aged 19 years or older admitted to the cardiology department with acute heart failure
* NT-proBNP \>300 pg/mL
* Clinician judgement of possible respiratory viral infection (fever \>38 degrees or cough, respiratory symptoms such as sputum or consolidation on x-ray or CRP \>5 mg/dL)
* Patients who have a nasopharyngeal swab for respiratory virus PCR test performed within 72 hours of admission for any of the 3 reasons

Exclusion Criteria

* Patients with a clear other cause of acute heart failure (ex. STEMI, bradycardia requiring a pacemaker, SBP \>200mmHg or DBP \>110mmHg, haemoglobin \<7g/dL)
* If the cause of pulmonary oedema is prominently attributed to exacerbation of CKD
* If there is a clear other source of infection that can explain the fever
Minimum Eligible Age

19 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Samsung Medical Center

OTHER

Sponsor Role collaborator

Seoul St. Mary's Hospital

OTHER

Sponsor Role collaborator

Minjae Yoon

OTHER

Sponsor Role lead

Responsible Party

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Minjae Yoon

Assistant professor

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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Seoul National University Bundang Hospital

Seongnam-si, Gyeonggi-do, South Korea

Site Status RECRUITING

Samsung medical center

Seoul, , South Korea

Site Status RECRUITING

Seoul ST. Mary's Hospital

Seoul, , South Korea

Site Status RECRUITING

Countries

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South Korea

Central Contacts

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Minjae Yoon, MD

Role: CONTACT

+82-10-6334-1917

Facility Contacts

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Minjae Yoon, MD

Role: primary

Darae Kim

Role: primary

Jong-Chan Youn

Role: primary

+82-10-8762-5683

Other Identifiers

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SNUBH IRB NO: B-2412-941-302

Identifier Type: -

Identifier Source: org_study_id

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