Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
NOT_YET_RECRUITING
PHASE3
42 participants
INTERVENTIONAL
2026-01-01
2027-08-01
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
Participants will:
* Use both Multiprofen-CC and a placebo (a cream with no active medicine) during the study, in a random order.
* Be asked to apply 1 gram of cream to their hands three times a day for 2 weeks, following the manufacturer's instructions.
* Attend a visit before starting the study, after 2 weeks, and after 6 weeks.
* Report any symptoms they experience during the study.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Trial Evaluating multimOdal toPical Cream In CompArison to pLacebo (TOPICAL)
NCT03199417
Colchicine as Treatment for People With Hand Osteoarthritis
NCT04601883
Metformin Treatment of Patients with Hand Osteoarthritis
NCT06367283
Clinical Trial to Examine the Pain Relief of PH-797804 Alone Or With Naproxen in Subjects With Osteoarthritis of the Knee
NCT01102660
Brain Imaging To Examine The Effect Of Naproxen In Hand Osteoarthritis Patients
NCT00830050
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
RANDOMIZED
CROSSOVER
TREATMENT
QUADRUPLE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
Multiprofen-CC™
Multiprofen-CC™ \[ketoprofen (10%), baclofen (5%), amitriptyline (2%), and lidocaine (5%)\] Dose: 1.0g, 3 times per day for 2 weeks
Multiprofen-CC™ plus standard treatment
Standard care pain medications and topical Multiprofen-CC™ (1g TID) for 2 weeks
Placebo
The placebo is the base cream with no medicinal ingredients Dose: 1.0g, 3 times per day for 2 weeks
Placebo plus standard treatment
Standard care pain medications and visually identical topical placebo (1g TID) for 2 weeks
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
Multiprofen-CC™ plus standard treatment
Standard care pain medications and topical Multiprofen-CC™ (1g TID) for 2 weeks
Placebo plus standard treatment
Standard care pain medications and visually identical topical placebo (1g TID) for 2 weeks
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* Have been diagnosed with hand osteoarthritis according to American College of Rheumatology criteria
* Experience pain and/or loss of function in one or both hands that interferes with daily life
* Provide informed consent
Exclusion Criteria
* Unable or unwilling to follow study protocol
* Known allergy or contraindication to any of the study drugs or their ingredients
* Have open wounds/cuts and/or skin conditions on the hand area
* Pregnant or breastfeeding
* History of impaired kidney or liver function
* Rheumatoid or other inflammatory arthropathy
* Hand surgery within the past 6 months or planned within the study period.
* Use daily opioids (other than short acting codeine) for a chronic pain condition other than hand arthritis
18 Years
ALL
No
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
The Research Institute of St Joe's Hamilton
UNKNOWN
McMaster University
OTHER
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Principal Investigators
Learn about the lead researchers overseeing the trial and their institutional affiliations.
Carolyn Levis, MD, MSc, FRCS(C)
Role: PRINCIPAL_INVESTIGATOR
McMaster University
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
St. Joseph's Healthcare Hamilton
Hamilton, Ontario, Canada
Countries
Review the countries where the study has at least one active or historical site.
Central Contacts
Reach out to these primary contacts for questions about participation or study logistics.
Facility Contacts
Find local site contact details for specific facilities participating in the trial.
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
MRP-HAND
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.