Nd:YAG vs Alexandrite Laser Treatment in Hidradenitis Suppurativa

NCT ID: NCT06960447

Last Updated: 2025-12-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

21 participants

Study Classification

INTERVENTIONAL

Study Start Date

2026-01-31

Study Completion Date

2027-07-31

Brief Summary

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The purpose of this study is to evaluate whether Alexandrite laser treatment is non-inferior to Nd:YAG (neodymium-doped yttrium aluminum garnet) laser treatment of hidradenitis suppurativa (HS).

Detailed Description

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Conditions

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Hidradenitis Suppurativa (HS)

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Split-person trial
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Receiving treatment with both laser types

Participants will receive split-body treatment, receiving Nd:YAG laser treatment to an affected anatomical site (axilla, inframammary region, or groin) and Alexandrite laser to the contralateral side. The treatment side will be randomized and maintained through the study.

Group Type EXPERIMENTAL

Nd:YAG Laser

Intervention Type DEVICE

Nd:YAG laser applied to one side of the participant's body (e.g. left or right) according to randomization, every 4-6 weeks for 4 consecutive treatments.

Alexandrite Laser

Intervention Type DEVICE

Alexandrite laser applied to the contralateral side of the participant's body (e.g. left or right) according to randomization, every 4-6 weeks for 4 consecutive treatments.

Interventions

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Nd:YAG Laser

Nd:YAG laser applied to one side of the participant's body (e.g. left or right) according to randomization, every 4-6 weeks for 4 consecutive treatments.

Intervention Type DEVICE

Alexandrite Laser

Alexandrite laser applied to the contralateral side of the participant's body (e.g. left or right) according to randomization, every 4-6 weeks for 4 consecutive treatments.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Geisinger male or female patients with a diagnosis of hidradenitis suppurativa (all stages of disease)
* 12-75 years of age
* Not on concurrent systemic therapy (e.g., antibiotics, biologic therapies)
* Must have not used systemic therapies within 2 weeks of enrollment in study
* Able and willing to provide consent

Exclusion Criteria

* Patients who cannot tolerate laser therapy
* Patients who cannot wear protective eyewear
* Patients who are pregnant
Minimum Eligible Age

12 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Geisinger Clinic

OTHER

Sponsor Role lead

Responsible Party

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Mickey Horissian

Assistant Professor of Dermatology

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Mikael K Horissian, MD

Role: PRINCIPAL_INVESTIGATOR

Geisinger Clinic

Central Contacts

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Saritha Research Project Manager

Role: CONTACT

570-214-3453

Other Identifiers

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2024-0947

Identifier Type: -

Identifier Source: org_study_id

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