Fluzoparib+Bevacizumab/Dietary Intervention vs Fluzoparib Monotherapy as First-line Maintenance in HRD+/- Advanced Ovarian Cancer

NCT ID: NCT06954584

Last Updated: 2025-06-24

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: PHASE3
• Total Enrollment: 424 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2025-05-27
• Study Completion Date: 2032-03-01

Brief Summary

Fluzoparib has been approved for the first-line maintenance treatment of advanced ovarian cancer in the full population . Previous studies have demonstrated that anti-angiogenic agents enhance tumor cell sensitivity to PARP inhibitors . In vitro evidence suggests that low-carbohydrate culture conditions may restore PARP inhibitor sensitivity in HRD-negative tumor cells. This study aims to validate the survival benefits of fluzoparib combined with bevacizumab in HRD-positive ovarian cancer patients during first-line maintenance therapy and explore the efficacy of fluzoparib combined with a dietary intervention in HRD-negative populations.

Conditions

Ovarian Cancer

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

HRD-Positive Cohort (Experimental Group): Fluzoparib + Bevacizumab

Fluzoparib Capsules : 150 mg orally twice daily (bid) (50 mg/capsule, 3 capsules/dose) .

Bevacizumab : 15 mg/kg intravenously every 3 weeks until disease progression or intolerable toxicity, with a maximum duration of 15 months .

Group Type: EXPERIMENTAL

Bevacizumab

Intervention Type: DRUG

Bevacizumab : 15 mg/kg intravenously every 3 weeks until disease progression or intolerable toxicity, with a maximum duration of 15 months

Fluzoparib Monotherapy

Intervention Type: DRUG

150 mg orally bid (50 mg/capsule, 3 capsules/dose)

HRD-Positive Cohort (Control Group): Fluzoparib Monotherapy

Fluzoparib Capsules : 150 mg orally bid (50 mg/capsule, 3 capsules/dose)

Group Type: ACTIVE_COMPARATOR

Fluzoparib Monotherapy

Intervention Type: DRUG

150 mg orally bid (50 mg/capsule, 3 capsules/dose)

HRD-Negative Cohort (Experimental Group 1): Fluzoparib + Dietary Intervention

Fluzoparib Capsules : 150 mg orally bid (50 mg/capsule, 3 capsules/dose)

Group Type: EXPERIMENTAL

Fluzoparib Monotherapy

Intervention Type: DRUG

150 mg orally bid (50 mg/capsule, 3 capsules/dose)

Dietary Intervention

Intervention Type: BEHAVIORAL

Control carbohydrate intake in the daily diet

HRD-Negative Cohort (Experimental Group 2): Fluzoparib Monotherapy

Fluzoparib Capsules : 150 mg orally bid (50 mg/capsule, 3 capsules/dose)

Group Type: EXPERIMENTAL

Fluzoparib Monotherapy

Intervention Type: DRUG

150 mg orally bid (50 mg/capsule, 3 capsules/dose)

Interventions

Bevacizumab

Bevacizumab : 15 mg/kg intravenously every 3 weeks until disease progression or intolerable toxicity, with a maximum duration of 15 months

Intervention Type: DRUG

Fluzoparib Monotherapy

150 mg orally bid (50 mg/capsule, 3 capsules/dose)

Intervention Type: DRUG

Dietary Intervention

Control carbohydrate intake in the daily diet

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

1. The participant voluntarily joins the study, provides written informed consent, demonstrates good compliance, and agrees to follow-up.

2. Female, age ≥18 years (calculated on the day of signing the informed consent form).

3. Histologically confirmed high-grade serous ovarian cancer, fallopian tube cancer, or primary peritoneal cancer ; endometrioid adenocarcinoma of the ovary (grade ≥II) :

For mixed tumors: The high-grade serous or grade ≥II endometrioid component must exceed 50% .

4. FIGO 2018 staging as Stage III or IV .

5. Documented HRD (Homologous Recombination Deficiency) test results .

6. Completed platinum-based chemotherapy with the following requirements:

• Patients unable to tolerate chemotherapy for definitive reasons must complete at least 4 cycles of platinum-based chemotherapy .
• Patients undergoing interval debulking surgery must complete at least 3 cycles of platinum-based chemotherapy post-surgery .

7. Prior to randomization, patients must have no evidence of disease (NED) or achieve complete response (CR) or partial response (PR) after first-line platinum-based chemotherapy, with response maintained until study treatment initiation. Randomization and treatment must begin within 8 weeks after the last chemotherapy dose .

-CR definition : No radiologic evidence of disease and CA125 ≤ upper limit of normal (ULN).

-PR definition : ≥30% reduction in tumor size compared to pre-chemotherapy or CA125 reduction ≥90% from baseline (if imaging shows no lesions but CA125 remains above ULN).

-For patients achieving NED after initial debulking surgery:CA125 must decrease to <1×ULN during treatment and remain <1×ULN within 7 days prior to randomization; or CA125 reduction ≥90% from baseline and no >10% increase within 7 days prior to randomization.

-Prohibited during/after platinum-based chemotherapy : Concurrent use of other investigational drugs (except endocrine therapy) or treatments.

-Permitted during chemotherapy : Bevacizumab combination therapy.

8. ECOG Performance Status (PS) : 0-1.

9. Adequate organ function (no blood transfusions or growth factors within 14 days prior to randomization):

-Absolute neutrophil count (ANC) ≥1.5×10⁹/L.

-Platelets ≥90×10⁹/L.

-Hemoglobin ≥9 g/dL.

-Serum albumin ≥3 g/dL.

-Total bilirubin ≤1.5×ULN.

-ALT and AST ≤2.5×ULN.

• Serum creatinine ≤1.5×ULN.

1 0.For women of childbearing potential :

• Negative serum pregnancy test within 72 hours prior to randomization.
• Agreement to use medically approved contraception during treatment and for 6 months after the last dose .
• Non-lactating.

11. Baseline body mass index (BMI) ≥18.5 kg/m² (BMI = weight [kg]/height [m]²).

Exclusion Criteria

1. History of other untreated or active malignancies within 5 years (except cured thyroid cancer, basal cell carcinoma, cervical carcinoma in situ, or breast cancer with >3 years of recurrence-free survival after radical surgery).

2. Untreated central nervous system (CNS) metastases :

-Patients with stable CNS metastases (confirmed by imaging for ≥1 month) after prior systemic/local therapy (e.g., surgery/radiotherapy) and off steroids (>10 mg/day prednisone equivalent) for >2 weeks may be eligible.

3. Prior use of PARP inhibitors (e.g., olaparib, niraparib, rucaparib, pamiparib, fluzoparib).

4 .Inability to swallow tablets or gastrointestinal dysfunction affecting drug absorption (per investigator judgment).

5.Bowel obstruction or gastrointestinal perforation within 3 months prior to randomization.

6.Symptomatic malignant ascites/pleural effusion requiring drainage or drainage within 3 months prior to randomization.

7.Poorly controlled cardiac disease :

• NYHA Class ≥II heart failure.
• Unstable angina.
• Myocardial infarction within 1 year.
• Clinically significant arrhythmias requiring treatment.
• QTc interval >470 ms. 8.Coagulation abnormalities :
• INR >1.5 or PT >ULN +4 seconds.
• Bleeding tendency or current use of thrombolytics/anticoagulants (low-dose LMWH or aspirin prophylaxis permitted).

9.Clinically significant bleeding within 3 months prior to randomization (e.g., gastrointestinal bleeding, hemorrhagic gastric ulcer, vasculitis).

• If baseline fecal occult blood test is positive, retesting is required. Persistent positivity may necessitate endoscopy.

10.Active ulcers, unhealed wounds, or fractures . 11.Uncontrolled hypertension (systolic ≥140 mmHg or diastolic ≥90 mmHg despite medication).

1 2.Grade ≥2 bleeding events (per CTCAE v5.0) within 4 weeks prior to randomization.

13.Active infection or unexplained fever >38.5°C during screening/prior to randomization.

14.Immunodeficiency or active hepatitis :

• HIV-positive.
• Active HBV (HBsAg+ and HBV DNA ≥500 IU/mL) or HCV (HCV Ab+ and HCV RNA >ULN).

1 5.Recent anticancer therapy :

• Chemotherapy, radiotherapy, hormonal therapy, or targeted therapy within 4 weeks prior to study treatment (or 5 half-lives for oral targeted agents).
• Residual toxicity from prior therapy >Grade 1 (CTCAE v5.0; alopecia excluded). 16.Arterial/venous thromboembolism within 6 months prior to randomization (e.g., stroke, transient ischemic attack, DVT, pulmonary embolism).

17.Hereditary/acquired bleeding disorders (e.g., hemophilia, thrombocytopenia).

18.Planned use of other systemic anticancer therapies during the study. 19.Any condition that, per investigator judgment, may lead to premature study termination.

20. Unintentional weight loss ≥5% within 3-6 months or presence of cachexia .

21. Nutritional risk :

-NRS2002 score ≥3 or need for nutritional support. 22.Diabetes requiring insulin or insulin secretagogues . 23.Acute liver disease/dysfunction . 24.Active chronic or acute kidney disease/dysfunction

• Minimum Eligible Age: 18 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: Yes

Sponsors

Tongji Hospital

OTHER

Sponsor Role: lead

Responsible Party

Qinglei Gao

chief physician

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Tongji Hospital

Wuhan, Hubei, China

Site Status: RECRUITING

Tongji Hospital

Wuhan, Hubei, China

Site Status: RECRUITING

Countries

China

Facility Contacts

Qinglei Gao

Role: primary

qingleigao@hotmail.com

027-83663131

Qinglei Gao

Role: primary

qingleigao@hotmail.com

027-83663131

Other Identifiers

MA-OC-III-013

Identifier Type: -

Identifier Source: org_study_id