A Study to Compare Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) Versus Pembrolizumab Alone as Treatment in Participants With Mismatch Repair Proficient Endometrial Cancer (MK-2870-033/TroFuse-033/GOG-3119/ENGOT-en29)

NCT ID: NCT06952504

Last Updated: 2025-11-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

PHASE3

Total Enrollment

1123 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-05-22

Study Completion Date

2032-05-24

Brief Summary

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Researchers are looking for new ways to treat people with proficient mismatch repair (pMMR) endometrial cancer (EC) that is advanced or recurrent.

* EC is a type of cancer that starts in the tissues inside the uterus (womb)
* pMMR indicates that certain normal proteins are present in the cancer cells
* Advanced means the cancer has spread locally or to other parts of the body (metastatic) and cannot be removed with surgery
* Recurrent means the cancer came back after surgery

Sacituzumab tirumotecan (also known as sac-TMT) and pembrolizumab are the study medicines. Sac-TMT is an antibody drug conjugate (ADC). An ADC attaches to specific targets on cancer cells and delivers treatment to destroy those cells.

The goal of this study is to learn if people who receive sac-TMT with pembrolizumab live longer and without the cancer getting worse compared to people who receive pembrolizumab alone.

Detailed Description

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All participants undergo an initial Induction Phase of six cycles, each cycle consisting of pembrolizumab + carboplatin + paclitaxel or docetaxel. Each cycle is three weeks. Participants whose cancer does not progress enter the Maintenance Treatment Phase and are then randomly assigned to pembrolizumab + sac-TMT or pembrolizumab monotherapy. Participants whose cancer does progress will have the possibility to enter the Subsequent Treatment Phase and are then randomly assigned to pembrolizumab + sac-TMT or sac-TMT monotherapy.

Conditions

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Endometrial Cancer

Keywords

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Programmed Cell Death-1 (PD1, PD-1) Programmed Cell Death 1 Ligand 1 (PDL1, PD-L1) Programmed Cell Death 1 Ligand 2 (PDL2, PD-L2) Trophoblast cell surface antigen 2 (TROP2)

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Participants are allocated to a single induction arm, then assigned randomly to either one of two maintenance treatment arms or one of two subsequent treatment arms.
Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Maintenance Treatment Arm A: Pembrolizumab + Sacituzumab Tirumotecan

During the Induction Phase, participants receive pembrolizumab 200 mg, carboplatin area under the curve (AUC) 5 (mg/mL/min), and paclitaxel 175 mg/m2 or docetaxel 75 mg/m2 on Day 1 of each 3-week cycle for 6 cycles (up to approximately 4 months).

During the Maintenance Treatment Phase, participants receive sac-TMT 4 mg/kg on Days 1, 15, and 29 of each 6-week cycle and pembrolizumab 400 mg on Day 1 of each 6-week cycle for up to 14 cycles (up to approximately 19 months).

Group Type EXPERIMENTAL

Pembrolizumab

Intervention Type BIOLOGICAL

Intravenous (IV) Infusion

Carboplatin

Intervention Type DRUG

During the Induction Phase, participants receive carboplatin AUC 5 (mg/mL/min) on Day 1 of each 3-week cycle for 6 cycles (up to approximately 4 months) via IV infusion.

Paclitaxel

Intervention Type DRUG

During the Induction Phase, participants receive paclitaxel 175 mg/m2 on Day 1 of each 3-week cycle for 6 cycles (up to approximately 4 months) via IV infusion.

Docetaxel

Intervention Type DRUG

During the Induction Phase, participants may receive docetaxel (in place of paclitaxel) 75 mg/m2 on Day 1 of each 3-week cycle for 6 cycles (up to approximately 4 months) via IV infusion.

Sacituzumab Tirumotecan

Intervention Type BIOLOGICAL

IV Infusion

Maintenance Treatment Arm B: Pembrolizumab Monotherapy

During the Induction Phase, participants receive pembrolizumab 200 mg, carboplatin AUC 5 (mg/mL/min), and paclitaxel 175 mg/m2 or docetaxel 75 mg/m2 on Day 1 of each 3-week cycle for 6 cycles (up to approximately 4 months).

During the Maintenance Treatment Phase, participants receive pembrolizumab 400 mg on Day 1 of each 6-week cycle for up to 14 cycles (up to approximately 19 months).

Group Type ACTIVE_COMPARATOR

Pembrolizumab

Intervention Type BIOLOGICAL

Intravenous (IV) Infusion

Carboplatin

Intervention Type DRUG

During the Induction Phase, participants receive carboplatin AUC 5 (mg/mL/min) on Day 1 of each 3-week cycle for 6 cycles (up to approximately 4 months) via IV infusion.

Paclitaxel

Intervention Type DRUG

During the Induction Phase, participants receive paclitaxel 175 mg/m2 on Day 1 of each 3-week cycle for 6 cycles (up to approximately 4 months) via IV infusion.

Docetaxel

Intervention Type DRUG

During the Induction Phase, participants may receive docetaxel (in place of paclitaxel) 75 mg/m2 on Day 1 of each 3-week cycle for 6 cycles (up to approximately 4 months) via IV infusion.

Subsequent Treatment Arm A: Pembrolizumab + Sacituzumab Tirumotecan

During the Induction Phase, participants receive pembrolizumab 200 mg, carboplatin AUC 5 (mg/mL/min), and paclitaxel 175 mg/m2 or docetaxel 75 mg/m2 on Day 1 of each 3-week cycle for 6 cycles (up to approximately 4 months).

During the Subsequent Treatment Phase, participants receive sac-TMT 4 mg/kg on Days 1, 15, and 29 of each 6-week cycle until discontinuation criteria is met and pembrolizumab 400 mg on Day 1 of each 6-week cycle for up to 14 cycles (up to approximately 19 months).

Group Type EXPERIMENTAL

Pembrolizumab

Intervention Type BIOLOGICAL

Intravenous (IV) Infusion

Carboplatin

Intervention Type DRUG

During the Induction Phase, participants receive carboplatin AUC 5 (mg/mL/min) on Day 1 of each 3-week cycle for 6 cycles (up to approximately 4 months) via IV infusion.

Paclitaxel

Intervention Type DRUG

During the Induction Phase, participants receive paclitaxel 175 mg/m2 on Day 1 of each 3-week cycle for 6 cycles (up to approximately 4 months) via IV infusion.

Docetaxel

Intervention Type DRUG

During the Induction Phase, participants may receive docetaxel (in place of paclitaxel) 75 mg/m2 on Day 1 of each 3-week cycle for 6 cycles (up to approximately 4 months) via IV infusion.

Sacituzumab Tirumotecan

Intervention Type BIOLOGICAL

IV Infusion

Subsequent Treatment Arm B: Sacituzumab Tirumotecan Monotherapy

During the Induction Phase, participants receive pembrolizumab 200 mg, carboplatin AUC 5 (mg/mL/min), and paclitaxel 175 mg/m2 or docetaxel 75 mg/m2 on Day 1 of each 3-week cycle for 6 cycles (up to approximately 4 months).

During the Subsequent Treatment Phase, participants receive sac-TMT 4 mg/kg on Days 1, 15, and 29 of each 6-week cycle until discontinuation criteria is met.

Group Type ACTIVE_COMPARATOR

Carboplatin

Intervention Type DRUG

During the Induction Phase, participants receive carboplatin AUC 5 (mg/mL/min) on Day 1 of each 3-week cycle for 6 cycles (up to approximately 4 months) via IV infusion.

Paclitaxel

Intervention Type DRUG

During the Induction Phase, participants receive paclitaxel 175 mg/m2 on Day 1 of each 3-week cycle for 6 cycles (up to approximately 4 months) via IV infusion.

Docetaxel

Intervention Type DRUG

During the Induction Phase, participants may receive docetaxel (in place of paclitaxel) 75 mg/m2 on Day 1 of each 3-week cycle for 6 cycles (up to approximately 4 months) via IV infusion.

Sacituzumab Tirumotecan

Intervention Type BIOLOGICAL

IV Infusion

Interventions

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Pembrolizumab

Intravenous (IV) Infusion

Intervention Type BIOLOGICAL

Carboplatin

During the Induction Phase, participants receive carboplatin AUC 5 (mg/mL/min) on Day 1 of each 3-week cycle for 6 cycles (up to approximately 4 months) via IV infusion.

Intervention Type DRUG

Paclitaxel

During the Induction Phase, participants receive paclitaxel 175 mg/m2 on Day 1 of each 3-week cycle for 6 cycles (up to approximately 4 months) via IV infusion.

Intervention Type DRUG

Docetaxel

During the Induction Phase, participants may receive docetaxel (in place of paclitaxel) 75 mg/m2 on Day 1 of each 3-week cycle for 6 cycles (up to approximately 4 months) via IV infusion.

Intervention Type DRUG

Sacituzumab Tirumotecan

IV Infusion

Intervention Type BIOLOGICAL

Other Intervention Names

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KEYTRUDA® MK-3475 SCH 900475 sac-TMT MK-2870 SKB264

Eligibility Criteria

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Inclusion Criteria

* Has a histologically confirmed diagnosis of primary advanced or recurrent endometrial carcinoma that has been confirmed as proficient mismatch repair (pMMR)
* Has radiographically evaluable disease, with measurable Stage III or either measurable or non-measurable Stage IV or recurrent disease per Response Evaluation Criteria In Solid Tumors version 1.1 (RECIST 1.1), as assessed by the investigator.
* Has received no prior systemic therapy for endometrial carcinoma except the following conditions as pre-specified by the protocol: 1 prior line of systemic platinum-based adjuvant and/or neoadjuvant chemotherapy in the setting of curative-intent, prior radiation with or without radiosensitizing chemotherapy if \>2 weeks before the start of induction treatment, or prior hormonal therapy for treatment of endometrial carcinoma that was discontinued ≥1 week before the start of induction treatment

Exclusion Criteria

* Has carcinosarcoma, neuroendocrine tumors or endometrial sarcoma, including stromal sarcoma, leiomyosarcoma, adenosarcoma, or other types of sarcomas
* Has endometrial carcinoma of any histology that is mismatch repair deficient (dMMR)
* Is a candidate for curative-intent surgery or curative-intent radiotherapy at the time of enrollment
* Has a history of documented severe dry eye syndrome, severe Meibomian gland disease and/or blepharitis, or severe corneal disease that prevents/delays corneal healing
* Has active inflammatory bowel disease requiring immunosuppressive medication or previous history of inflammatory bowel disease
* Has uncontrolled, significant cardiovascular disease or cerebrovascular disease
* Human Immunodeficiency Virus-infected participants with a history of Kaposi's sarcoma and/or Multicentric Castleman's Disease
* Received prior therapy in any setting with any of the following: anti-programmed cell death 1 protein, anti-programmed cell death ligand 1, anti-programmed cell death ligand 2 agent, or with an agent directed to another stimulatory or coinhibitory T-cell receptor; trophoblast cell surface antigen 2-targeted antibody drug conjugate; or topoisomerase I inhibitor-containing antibody drug conjugate
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Merck Sharp & Dohme LLC

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Medical Director

Role: STUDY_DIRECTOR

Merck Sharp & Dohme LLC

Locations

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University of South Alabama, Mitchell Cancer Institute ( Site 6033)

Mobile, Alabama, United States

Site Status RECRUITING

Alaska Women's Cancer Care ( Site 6036)

Anchorage, Alaska, United States

Site Status RECRUITING

University of California, Irvine (UCI) Health - UC Irvine Medical Center ( Site 6020)

Orange, California, United States

Site Status RECRUITING

MedStar Washington Hospital Center ( Site 5005)

Washington D.C., District of Columbia, United States

Site Status RECRUITING

Florida Cancer Specialists - South ( Site 7003)

Fort Myers, Florida, United States

Site Status RECRUITING

Mount Sinai Cancer Center ( Site 6031)

Miami Beach, Florida, United States

Site Status RECRUITING

Florida Cancer Specialists - North ( Site 7002)

St. Petersburg, Florida, United States

Site Status RECRUITING

Florida Cancer Specialists East ( Site 7001)

West Palm Beach, Florida, United States

Site Status RECRUITING

St. Joseph's/Candler Health System ( Site 6021)

Savannah, Georgia, United States

Site Status RECRUITING

Parkview Research Center ( Site 6008)

Fort Wayne, Indiana, United States

Site Status RECRUITING

Women's Cancer Care ( Site 6010)

Covington, Louisiana, United States

Site Status RECRUITING

TRIALS 365 ( Site 6005)

Shreveport, Louisiana, United States

Site Status RECRUITING

Maine Medical Center - Scarborough Campus ( Site 6042)

Scarborough, Maine, United States

Site Status RECRUITING

Minnesota Oncology Hematology, PA ( Site 8003)

Minneapolis, Minnesota, United States

Site Status RECRUITING

St. Dominic's Hospital ( Site 5004)

Jackson, Mississippi, United States

Site Status RECRUITING

Holy Name Medical Center ( Site 6011)

Teaneck, New Jersey, United States

Site Status RECRUITING

University of New Mexico Comprehensive Cancer Center ( Site 6046)

Albuquerque, New Mexico, United States

Site Status RECRUITING

Perlmutter Cancer Center at NYU Langone Hospital - Long Island ( Site 6055)

Mineola, New York, United States

Site Status RECRUITING

Laura and Isaac Perlmutter Cancer Center at NYU Langone ( Site 6004)

New York, New York, United States

Site Status RECRUITING

FirstHealth of the Carolinas ( Site 6037)

Pinehurst, North Carolina, United States

Site Status RECRUITING

Miami Valley Hospital South ( Site 6014)

Centerville, Ohio, United States

Site Status RECRUITING

Oklahoma Cancer Specialists and Research Institute, LLC ( Site 6047)

Tulsa, Oklahoma, United States

Site Status RECRUITING

St. Luke's University Health Network ( Site 6041)

Bethlehem, Pennsylvania, United States

Site Status RECRUITING

Hospital of the University of Pennsylvania ( Site 5007)

Philadelphia, Pennsylvania, United States

Site Status RECRUITING

Hospital of the University of Pennsylvania ( Site 6023)

Philadelphia, Pennsylvania, United States

Site Status RECRUITING

Women & Infants Hospital ( Site 5003)

Providence, Rhode Island, United States

Site Status RECRUITING

Texas Oncology - DFW ( Site 8004)

Fort Worth, Texas, United States

Site Status RECRUITING

Texas Oncology-San Antonio Medical Center ( Site 8001)

San Antonio, Texas, United States

Site Status RECRUITING

Texas Oncology - Northeast Texas ( Site 8002)

Tyler, Texas, United States

Site Status RECRUITING

Inova Schar Cancer Institute ( Site 6003)

Fairfax, Virginia, United States

Site Status RECRUITING

Instituto Alexander Fleming ( Site 0105)

Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina

Site Status RECRUITING

Instituto de Investigaciones Clínicas Mar del Plata ( Site 0108)

Mar del Plata, Buenos Aires, Argentina

Site Status RECRUITING

Fundación Respirar ( Site 0101)

Buenos Aires, Buenos Aires F.D., Argentina

Site Status RECRUITING

Hospital Británico de Buenos Aires ( Site 0103)

CABA, , Argentina

Site Status RECRUITING

Instituto San Marcos ( Site 0106)

San Juan, , Argentina

Site Status RECRUITING

Blacktown Hospital ( Site 0201)

Blacktown, New South Wales, Australia

Site Status RECRUITING

Royal Brisbane and Women's Hospital ( Site 0206)

Brisbane, Queensland, Australia

Site Status RECRUITING

Epworth Freemasons ( Site 0207)

Melbourne, Victoria, Australia

Site Status RECRUITING

Medizinische Universitaet Innsbruck-Univ.-Klinik f. Gynäkologie und Geburtshilfe ( Site 0301)

Innsbruck, Tyrol, Austria

Site Status RECRUITING

Medizinische Universität Wien - Allg. Gynaekologie & Gyn. Onkologie ( Site 0302)

Vienna, , Austria

Site Status RECRUITING

CHU Saint-Pierre ( Site 0405)

Brussels, Bruxelles-Capitale, Region de, Belgium

Site Status RECRUITING

AZ Maria Middelares ( Site 0402)

Ghent, Oost-Vlaanderen, Belgium

Site Status RECRUITING

UZ Leuven ( Site 0401)

Leuven, Vlaams-Brabant, Belgium

Site Status RECRUITING

Grand Hôpital de Charleroi ( Site 0403)

Charleroi, Wallonne, Region, Belgium

Site Status RECRUITING

CHU de Liege ( Site 0404)

Liège, Wallonne, Region, Belgium

Site Status RECRUITING

Hospital Araújo Jorge ( Site 0521)

Goiânia, Goiás, Brazil

Site Status RECRUITING

IBCC - Instituto Brasileiro de Controle do Câncer ( Site 0525)

São Paulo, São Paulo, Brazil

Site Status RECRUITING

Princess Margaret Cancer Center ( Site 0609)

Toronto, Ontario, Canada

Site Status RECRUITING

Centre Hospitalier de l Universite de Montreal - CHUM ( Site 0605)

Montreal, Quebec, Canada

Site Status RECRUITING

Jewish General Hospital ( Site 0606)

Montreal, Quebec, Canada

Site Status RECRUITING

McGill University Health Centre ( Site 0604)

Montreal, Quebec, Canada

Site Status RECRUITING

CIUSSS de l Estrie - CHUS - Centre Hosp. Univ. Sherbrooke ( Site 0608)

Sherbrooke, Quebec, Canada

Site Status RECRUITING

Centro de Estudios Clínicos SAGA ( Site 0708)

Santiago, Region M. de Santiago, Chile

Site Status RECRUITING

FALP ( Site 0702)

Santiago, Region M. de Santiago, Chile

Site Status RECRUITING

Pontificia Universidad Catolica de Chile ( Site 0705)

Santiago, Region M. de Santiago, Chile

Site Status RECRUITING

Bradfordhill ( Site 0703)

Santiago, Region M. de Santiago, Chile

Site Status RECRUITING

ONCOCENTRO APYS ( Site 0704)

Viña del Mar, Región de Valparaíso, Chile

Site Status RECRUITING

Peking University Peoples Hospital ( Site 0845)

Beijing, Beijing Municipality, China

Site Status RECRUITING

Chongqing University Cancer Hospital ( Site 0838)

Chongqing, Chongqing Municipality, China

Site Status RECRUITING

Sun Yat-sen University Cancer Center ( Site 0846)

Guangzhou, Guangdong, China

Site Status RECRUITING

Zhujiang Hospital of Southern Medical University ( Site 0829)

Guangzhou, Guangdong, China

Site Status RECRUITING

Cancer Hospital of Shantou University Medical College ( Site 0827)

Shantou, Guangdong, China

Site Status RECRUITING

Affiliated Hospital of Guangdong Medical University ( Site 0823)

Zhanjiang, Guangdong, China

Site Status RECRUITING

Liuzhou People's Hospital ( Site 0831)

Liuzhou, Guangxi, China

Site Status RECRUITING

Guangxi Medical University Affiliated Tumor Hospital. ( Site 0825)

Nanning, Guangxi, China

Site Status RECRUITING

Wuhan Union Hospital Cancer Center ( Site 0824)

Wuhan, Hubei, China

Site Status RECRUITING

Nanjing First Hospital ( Site 0828)

Nanjing, Jiangsu, China

Site Status RECRUITING

Jiangxi Maternal and Child Health Hospital ( Site 0807)

Nanchang, Jiangxi, China

Site Status RECRUITING

The First Hospital Of Jilin University ( Site 0815)

Changchun, Jilin, China

Site Status RECRUITING

The First Affiliated Hospital of Xi'an Jiaotong University ( Site 0816)

Xi'an, Shaanxi, China

Site Status RECRUITING

Shandong Cancer Hospital ( Site 0803)

Jinan, Shandong, China

Site Status RECRUITING

Shanghai Tenth People's Hospital ( Site 0847)

Shanghai, Shanghai Municipality, China

Site Status RECRUITING

Obstetrics & Gynecology Hospital of Fudan University ( Site 0818)

Shanghai, Shanghai Municipality, China

Site Status RECRUITING

The Second People's Hospital of Yibin ( Site 0840)

Yibin, Sichuan, China

Site Status RECRUITING

The Affiliated Women's Hospital of Zhejiang University ( Site 0834)

Hangzhou, Zhejiang, China

Site Status RECRUITING

Taizhou Hospital of Zhejiang Province ( Site 0809)

Linhai, Zhejiang, China

Site Status RECRUITING

The First Affiliated Hospital of Wenzhou Medical University ( Site 0805)

Wenzhou, Zhejiang, China

Site Status RECRUITING

Instituto de Cancerología S.A.S ( Site 0904)

Medellín, Antioquia, Colombia

Site Status RECRUITING

Fundacion Colombiana de Cancerología Clinica Vida ( Site 0905)

Medellín, Antioquia, Colombia

Site Status RECRUITING

FUNDACION CTIC CENTRO DE TRATAMIENTO E INVESTIGACION SOBRE CANCER LUIS CARLOS SARMIENTO ANGULO ( Site 0902)

Bogotá, Bogota D.C., Colombia

Site Status RECRUITING

Oncologos Del Occidente ( Site 0907)

Pereira, Risaralda Department, Colombia

Site Status RECRUITING

Nemocnice AGEL Novy Jicin a.s. ( Site 1102)

Nový Jičín, , Czechia

Site Status RECRUITING

Vseobecna fakultni nemocnice v Praze-Gynekologicko-porodnicka klinika 1.LF a VFN ( Site 1101)

Prague, , Czechia

Site Status RECRUITING

Fakultni nemocnice v Motole-Onkologicka klinika 2. LF UK a FN Motol ( Site 1103)

Prague, , Czechia

Site Status RECRUITING

Aarhus Universitetshospital, Skejby ( Site 1205)

Aarhus, Central Jutland, Denmark

Site Status RECRUITING

Roskilde Sygehus ( Site 1204)

Roskilde, Region Sjælland, Denmark

Site Status RECRUITING

Kuopion Yliopistollinen Sairaala ( Site 1304)

Kuopio, Northern Savonia, Finland

Site Status RECRUITING

Tampereen yliopistollinen sairaala ( Site 1303)

Tampere, Pirkanmaa, Finland

Site Status RECRUITING

Turku University Hospital-Department of Obstetrics and Gynecology ( Site 1302)

Turku, Southwest Finland, Finland

Site Status RECRUITING

Helsinki University Hospital - Comprehensive Cancer Center (HYKS - Syöpäkeskus) ( Site 1301)

Helsinki, Uusimaa, Finland

Site Status RECRUITING

Centre Francois Baclesse ( Site 1412)

Caen, Calvados, France

Site Status RECRUITING

Hôpital Privé Des Côtes d'Armor ( Site 1404)

Plérin, Cotes-d Armor, France

Site Status RECRUITING

Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest ( Site 1405)

Bordeaux, Gironde, France

Site Status RECRUITING

Oncopole Claudius Regaud ( Site 1407)

Toulouse, Haute-Garonne, France

Site Status RECRUITING

Institut Curie - site Saint-Cloud ( Site 1408)

Saint-Cloud, Hauts-de-Seine, France

Site Status RECRUITING

CENTRE LEON BERARD ( Site 1401)

Lyon, Rhone, France

Site Status RECRUITING

Hopitaux Universitaires Paris Centre-Hopital Cochin ( Site 1411)

Paris, , France

Site Status RECRUITING

CaritasKlinikum Saarbrücken St. Theresia ( Site 1508)

Saarbrücken, Saarland, Germany

Site Status RECRUITING

Alexandra General Hospital of Athens ( Site 1604)

Athens, Attica, Greece

Site Status RECRUITING

Aretaieio Hospital ( Site 1602)

Athens, Attica, Greece

Site Status RECRUITING

Agios Loukas Clinic-DEPARTMENT OF ONCOLOGY ( Site 1601)

Thessaloniki, Central Macedonia, Greece

Site Status RECRUITING

Debreceni Egyetem Klinikai Kozpont-Szülészeti és Nőgyógyászati Klinika ( Site 1701)

Debrecen, , Hungary

Site Status RECRUITING

Rambam Health Care Campus ( Site 2025)

Haifa, , Israel

Site Status RECRUITING

Carmel Hospital ( Site 2023)

Haifa, , Israel

Site Status RECRUITING

Shaare Zedek Medical Center ( Site 2020)

Jerusalem, , Israel

Site Status RECRUITING

Sourasky Medical Center ( Site 2022)

Tel Aviv, , Israel

Site Status RECRUITING

IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori" ( Site 2107)

Meldola, Forli-Cesena, Italy

Site Status RECRUITING

Ospedale Cannizzaro ( Site 2103)

Catania, , Italy

Site Status RECRUITING

Azienda Ospedaliera Universitaria Careggi ( Site 2109)

Florence, , Italy

Site Status RECRUITING

Istituto Europeo di Oncologia ( Site 2110)

Milan, , Italy

Site Status RECRUITING

Istituto Nazionale Tumori IRCCS Fondazione Pascale ( Site 2104)

Napoli, , Italy

Site Status RECRUITING

Ehime University Hospital ( Site 2213)

Tōon, Ehime, Japan

Site Status RECRUITING

Kurume University Hospital ( Site 2204)

Kurume, Fukuoka, Japan

Site Status RECRUITING

Gunma Prefectural Cancer Center ( Site 2202)

Ōta, Gunma, Japan

Site Status RECRUITING

National Hospital Organization Hokkaido Cancer Center ( Site 2212)

Sapporo, Hokkaido, Japan

Site Status RECRUITING

Hyogo Cancer Center ( Site 2216)

Akashi, Hyōgo, Japan

Site Status RECRUITING

Iwate Medical University Hospital ( Site 2207)

Shiwa-gun, Iwate, Japan

Site Status RECRUITING

Saitama Medical University International Medical Center ( Site 2201)

Hidaka, Saitama, Japan

Site Status RECRUITING

Cancer Institute Hospital of JFCR ( Site 2208)

Koto, Tokyo, Japan

Site Status RECRUITING

Keio University Hospital ( Site 2209)

Shinjuku, Tokyo, Japan

Site Status RECRUITING

National Hospital Organization Kyushu Cancer Center ( Site 2203)

Fukuoka, , Japan

Site Status RECRUITING

Niigata Cancer Center Hospital ( Site 2210)

Niigata, , Japan

Site Status RECRUITING

Okayama University Hospital ( Site 2215)

Okayama, , Japan

Site Status RECRUITING

Stavanger Universitetssykehus ( Site 2703)

Norway, Rogaland, Norway

Site Status RECRUITING

Universitetssykehuset Nord-Norge HF ( Site 2702)

Tromsø, Troms, Norway

Site Status RECRUITING

Oslo universitetssykehus, Radiumhospitalet ( Site 2701)

Oslo, , Norway

Site Status RECRUITING

Clínica San Felipe ( Site 2804)

Jesus Maria, Lima region, Peru

Site Status RECRUITING

IPOR Instituto Peruano de Oncología & Radioterapia ( Site 2803)

San Isidro, Lima region, Peru

Site Status RECRUITING

INSTITUTO NACIONAL DE ENFERMEDADES NEOPLASICAS ( Site 2805)

Lima, , Peru

Site Status RECRUITING

Uniwersytecki Szpital Kliniczny w Poznaniu ( Site 3011)

Poznan, Greater Poland Voivodeship, Poland

Site Status RECRUITING

Wielkopolskie Centrum Onkologii im. Marii Skłodowskiej-Curie ( Site 3003)

Poznan, Greater Poland Voivodeship, Poland

Site Status RECRUITING

Mazowiecki Szpital Wojewódzki w Siedlcach-Siedleckie Centrum Onkologii ( Site 3004)

Siedlce, Masovian Voivodeship, Poland

Site Status RECRUITING

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie ( Site 3002)

Warsaw, Masovian Voivodeship, Poland

Site Status RECRUITING

Uniwersyteckie Centrum Kliniczne-Klinika Ginekologii, Ginekologii Onkologicznej i Endokrynologii Gi ( Site 3001)

Gdansk, Pomeranian Voivodeship, Poland

Site Status RECRUITING

Narodowy Instytut Onkologii - Oddzial w Gliwicach ( Site 3006)

Gliwice, Silesian Voivodeship, Poland

Site Status RECRUITING

Swietokrzyskie Centrum Onkologii. ( Site 3008)

Kielce, Świętokrzyskie Voivodeship, Poland

Site Status RECRUITING

Puerto Rico Cancer Specialists Clinical Trials ( Site 4201)

San Juan, , Puerto Rico

Site Status RECRUITING

National University Hospital ( Site 3202)

Singapore, Central Singapore, Singapore

Site Status RECRUITING

National Cancer Centre Singapore ( Site 3201)

Singapore, Central Singapore, Singapore

Site Status RECRUITING

National Cancer Center ( Site 3106)

Gyeonggi-do, Kyonggi-do, South Korea

Site Status RECRUITING

Keimyung University Dongsan Hospital ( Site 3105)

Daegu, Taegu-Kwangyokshi, South Korea

Site Status RECRUITING

Seoul National University Hospital ( Site 3102)

Seoul, , South Korea

Site Status RECRUITING

Severance Hospital, Yonsei University Health System ( Site 3101)

Seoul, , South Korea

Site Status RECRUITING

Asan Medical Center ( Site 3103)

Seoul, , South Korea

Site Status RECRUITING

Institut Català d'Oncologia - L'Hospitalet ( Site 3408)

L'Hospitalet de Llobregat, Barcelona, Spain

Site Status RECRUITING

Institut Català d'Oncologia (ICO) - Girona ( Site 3407)

Girona, Gerona, Spain

Site Status RECRUITING

Hospital Universitari Vall d''Hebron ( Site 3401)

Barcelona, , Spain

Site Status RECRUITING

Hospital Universitario Reina Sofia ( Site 3402)

Córdoba, , Spain

Site Status RECRUITING

Hospital Universitario Ramon y Cajal ( Site 3403)

Madrid, , Spain

Site Status RECRUITING

Hospital Universitario 12 de Octubre ( Site 3404)

Madrid, , Spain

Site Status RECRUITING

Fundación Instituto Valenciano de Oncología ( Site 3405)

Valencia, , Spain

Site Status RECRUITING

Skånes Universitetssjukhus Lund ( Site 3502)

Lund, Skåne County, Sweden

Site Status RECRUITING

Akademiska Sjukhuset ( Site 3501)

Uppsala, Uppsala County, Sweden

Site Status RECRUITING

Taichung Veterans General Hospital ( Site 3703)

Taichung, , Taiwan

Site Status RECRUITING

National Cheng Kung University Hospital ( Site 3702)

Tainan, , Taiwan

Site Status RECRUITING

National Taiwan University Hospital ( Site 3701)

Taipei, , Taiwan

Site Status RECRUITING

Mackay Memorial Hospital ( Site 3704)

Taipei, , Taiwan

Site Status RECRUITING

Linkou Chang Gung Memorial Hospital ( Site 3705)

Taoyuan District, , Taiwan

Site Status RECRUITING

Ramathibodi Hospital. ( Site 3802)

Bangkok, Bangkok, Thailand

Site Status RECRUITING

Faculty of Medicine Siriraj Hospital ( Site 3801)

Bangkok, Bangkok, Thailand

Site Status RECRUITING

Maharaj Nakorn Chiang Mai Hospital ( Site 3804)

Chiang Mai, , Thailand

Site Status RECRUITING

Faculty of Medicine - Khon Kaen University ( Site 3803)

Khon Kaen, , Thailand

Site Status RECRUITING

University Hospitals Sussex NHS Foundation Trust ( Site 4011)

East Sussex, Brighton And Hove, United Kingdom

Site Status RECRUITING

ROYAL MARSDEN HOSPITAL (CHELSEA) ( Site 4006)

London, London, City of, United Kingdom

Site Status RECRUITING

Hammersmith Hospital ( Site 4010)

London, London, City of, United Kingdom

Site Status RECRUITING

Western General Hospital ( Site 4012)

Edinburgh, Midlothian, United Kingdom

Site Status RECRUITING

Royal Marsden Hospital (Sutton) ( Site 4005)

London, Surrey, United Kingdom

Site Status RECRUITING

The Christie NHS Foundation Trust ( Site 4003)

Manchester, , United Kingdom

Site Status RECRUITING

Countries

Review the countries where the study has at least one active or historical site.

United States Argentina Australia Austria Belgium Brazil Canada Chile China Colombia Czechia Denmark Finland France Germany Greece Hungary Israel Italy Japan Norway Peru Poland Puerto Rico Singapore South Korea Spain Sweden Taiwan Thailand United Kingdom

Central Contacts

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Toll Free Number

Role: CONTACT

Phone: 1-888-577-8839

Email: [email protected]

Facility Contacts

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Related Links

Access external resources that provide additional context or updates about the study.

https://www.merckclinicaltrials.com/

Merck Clinical Trials Information

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

2024-519331-42-00

Identifier Type: REGISTRY

Identifier Source: secondary_id

U1111-1315-0794

Identifier Type: REGISTRY

Identifier Source: secondary_id

GOG-3119

Identifier Type: OTHER

Identifier Source: secondary_id

ENGOT-en29

Identifier Type: OTHER

Identifier Source: secondary_id

TroFuse-033

Identifier Type: OTHER

Identifier Source: secondary_id

jRCT2011250020

Identifier Type: REGISTRY

Identifier Source: secondary_id

2870-033

Identifier Type: -

Identifier Source: org_study_id