Impact of Nutritional Supplementation on Sleep Quality

NCT ID: NCT06935123

Last Updated: 2025-04-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

PHASE1

Total Enrollment

376 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-04-11

Study Completion Date

2025-10-30

Brief Summary

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This is a randomized, double-blind, placebo-controlled, 5-arm parallel-group study to evaluate the effects of 4 nutritional supplements on sleep over a 12 week period in healthy U.S. adults.

Detailed Description

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Conditions

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Sleep Sleep Quality

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Randomised, Double-Blind, Placebo-Controlled, Parallel
Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Sleep Supplement 1

Participants served Sleep Supplement 1

Group Type ACTIVE_COMPARATOR

Sleep Supplements

Intervention Type DIETARY_SUPPLEMENT

Sleep supplements

Sleep Supplement 2

Participants served Sleep Supplement 2

Group Type ACTIVE_COMPARATOR

Sleep Supplements

Intervention Type DIETARY_SUPPLEMENT

Sleep supplements

Sleep Supplement 3

Participants served Sleep Supplement 3

Group Type ACTIVE_COMPARATOR

Sleep Supplements

Intervention Type DIETARY_SUPPLEMENT

Sleep supplements

Sleep Supplement 4

Participants served Sleep Supplement 4

Group Type ACTIVE_COMPARATOR

Sleep Supplements

Intervention Type DIETARY_SUPPLEMENT

Sleep supplements

Placebo

Participants served placebo

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type OTHER

Matching placebo

Interventions

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Sleep Supplements

Sleep supplements

Intervention Type DIETARY_SUPPLEMENT

Placebo

Matching placebo

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1. Be able to give written informed consent.
2. Be between 18-65 years of age (inclusive).
3. Insomnia severity Index score ≤14.
4. PROMIS Sleep Disturbance Questionnaire raw score ≥23
5. Be willing to maintain stable dietary habits and physical activity levels throughout the study period.
6. Willing to consume the study product daily for the duration of the study.

Exclusion Criteria

1. Participants who are pregnant or wish to become pregnant during the study or who are lactating and/or currently breastfeeding.
2. Participants currently of biological childbearing potential, but not using a continuous effective method of contraception as determined by the investigator.
3. Has a history of drug and/or alcohol abuse.
4. Hypersensitive to the contents of the study product.
5. Participants with work schedules that result in irregular sleep patterns/ or have night-shift employment.
6. High caffeine intake, \>400mg/day.
7. Has any significant acute or chronic coexisting health conditions that would prevent them from fulfilling the study requirements, put the Participant at risk or would confound the interpretation of the study results as judged by the investigator on the basis of medical history. Excluded health conditions include:

1. Diagnosed Sleep disorders
2. Major psychiatric diagnosis (e.g., bipolar), as diagnosed by a healthcare professional, including major depressive disorder (e.g., clinical depression)
3. Immunocompromised health conditions
8. Currently or recently (in the past 4 weeks) taking a medication that the investigator believes would interfere with the objectives of the study or pose a safety risk or confound the interpretation of the study results. Prohibited medications include:

1. Prescribed sleep medications
2. Prescribed Medications which impact sleep, including but not limited to sedative hypnotics, anxiolytics, and antidepressants.
9. Current or recent (in the past 4 weeks) use of prohibited nutritional and non-nutritional supplements with known or possible sleep effects (e.g. valerian, multivitamins, melatonin)
10. Individuals who, in the opinion of the investigator, are considered to be poor attendees or unlikely for any reason to be able to comply with the study.
11. Participants may not be participating in other clinical studies. If the participant has previously taken part in an experimental study, the Investigator must ensure sufficient time has elapsed before entry to this study to ensure the integrity of the results.
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Pharmavite LLC

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Atlantia Clinical Trials Inc., 142 E. Ontario, Suite 1200

Chicago, Illinois, United States

Site Status

Countries

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United States

Other Identifiers

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AFCRO-189

Identifier Type: -

Identifier Source: org_study_id

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