Hemithoracic Arc Radiotherapy Post Pleural Decortication

NCT ID: NCT06910449

Last Updated: 2025-04-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

45 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-11-11

Study Completion Date

2027-02-28

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Malignant Pleural Mesothelioma is an aggressive and refractory disease , the most aggressive treatment plan offered to these patients include trimodalitiy approach with chemotherapy as the mainstay of treatment . the rationale of post operative Radiotherapy is to sterilize the post operative volume to reduce local failure meanwhile minimizing toxicities in this trial we are going to assess the safety and efficacy of Radiotherapy in Mesothelioma patients poat Pleural decortication

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

This study will include malignant Pleural Mesothelioma patients treated by trimodalitiy approach starting with neoadjuvant chemotherapy followed by surgery in the form of Pleural decortication then all patients will receive post operative hemithoracic radiation

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Malignant Pleural Mesothelioma

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

single arm receiving postoperative radiotherapy

single arm receiving post operative Radiotherapy to the hemithorax

Group Type EXPERIMENTAL

hemithoracic Volumetric Arc Radiotherapy post Pleural decortication

Intervention Type RADIATION

post operative delivery of hemithoracic Volumetric Arc Radiotherapy

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

hemithoracic Volumetric Arc Radiotherapy post Pleural decortication

post operative delivery of hemithoracic Volumetric Arc Radiotherapy

Intervention Type RADIATION

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Evidence of metastatic disease.
* Underwent Pleural decortication.
* Able to provide informed consent.

Exclusion Criteria

* Poor pulmonary function tests.
* Recurrent or palliative cases.
* Inability to attend full course of Radiotherapy or follow up visits.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Cairo University

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Esraa Gamal

Assistant Lecturer of Radiation Oncology

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

national Cancer Institute Cairo university

Cairo, Fom Elkhalig, Egypt

Site Status RECRUITING

Countries

Review the countries where the study has at least one active or historical site.

Egypt

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

Gamal

Role: CONTACT

01000704731

Facility Contacts

Find local site contact details for specific facilities participating in the trial.

Fom El khalig

Role: primary

20225328286

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

RO2405-291-047-193

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Short Neoadjuvant Hemithoracic IMRT for MPM
NCT00797719 ACTIVE_NOT_RECRUITING PHASE1/PHASE2
The IMmunotherapy Pleural 5-ALA PDT
NCT04400539 RECRUITING PHASE2
Kypho-IORT vs. EBRT in Spinal Metastases
NCT02773966 TERMINATED PHASE3