Sugammadex Reduces Antiemetic Effect of Dexamethasone

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-04-01

Study Completion Date

2025-07-15

Brief Summary

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Sugammadex is a medication used for reversal of muscle relaxation during procedures under general anesthesia. It works by encapsulating muscle relaxant molecules with a steroid ring in its structure. On the other hand, postoporative nause and vomiting (PONV) is an adverse outcome during anesthesia. PONV can be prevented with pharmacologic agents such as ondansetron and dexamethasone. Dexamethasone is a steroidal agent that can interact with sugammadex. In theory, this interaction could lead to reduced effectiveness of sugammadex. In fact, several studies have explored this interaction. However, the effect of sugammadex on the antiemetic effect of dexamethasone has not been evaluated. This study intends to evaluate this interaction.

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Detailed Description

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The study will use de-identified retrospective data to conduct a cross-sectional study to determine the effect of sugammadex on the antiemetic efficacy of dexamethasone in elective adult surgical patients who underwent surgery in a tertiary care center between January 1 2023 and January 1 2024 . The investigators will conduct univariate and multivariate analysis to assess the effect.

Conditions

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PONV

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Dexamethasone

Surgical patients who received dexamethasone as prophylactic antiemetic

No interventions assigned to this group

Dexamethasone + sugammadex

Patients who received dexamethasone intraoperatively and sugammadex to reverse muscle relaxation

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Older than 18 years old
* Elective surgery
* ASA 1, 2, 3
* At least one risk factor for PONV

Exclusion Criteria

* Pregnancy
* Receiving antiemetics prior to arrival to preoperative holding area
* Receiving opioids prior to arrival to preoperative holding area
* Admission to ICU
* Altered mental status
* Rapid sequence induction
* Nausea or vomiting before surgery

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No