A Study of Allogeneic Hematopoietic Cell Transplantation for Primary Progressive Multiple Sclerosis

NCT ID: NCT06900192

Last Updated: 2025-03-28

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Clinical Phase: PHASE1
• Total Enrollment: 10 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2025-03-31
• Study Completion Date: 2029-08-31

Brief Summary

A study of alloHCT with Orca-Q for the treatment of primary progressive multiple sclerosis (MS).

Detailed Description

This study will evaluate alloHCT with Orca-Q, an allogeneic hematopoietic graft isolated from a donor's hematopoietic cells for the treatment of primary progressive MS.

Conditions

Primary Progressive Multiple Sclerosis; Multiple Sclerosis; Multiple Sclerosis, Primary Progressive; Multiple Sclerosis, Secondary Progressive

Study Design

• Allocation Method: NA
• Intervention Model: SEQUENTIAL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Orca-Q Graft with lymphodepleting conditioning regimen

Donor Orca-Q stem cell graft

Group Type: EXPERIMENTAL

Orca-Q

Intervention Type: BIOLOGICAL

Allogeneic (donor) stem cell graft

myeloablative regimen

Intervention Type: DRUG

Myeloablative regimen of busulfan, fludarabine, and thiotepa.

Interventions

Orca-Q

Allogeneic (donor) stem cell graft

Intervention Type: BIOLOGICAL

myeloablative regimen

Myeloablative regimen of busulfan, fludarabine, and thiotepa.

Intervention Type: DRUG

Other Intervention Names

busulfan; fludarabine; thiotepa

Eligibility Criteria

Inclusion Criteria

1. Participants aged ≥18 and ≤65 years with primary progressive multiple sclerosis

2. A diagnosis of PPMS by 2017 McDonald criteria and 2013 clinical course revision102

3. CSF with elevated IgG index or 2 or more oligoclonal bands

4. EDSS (see Appendix 9) between 2.0 and 5.5 inclusive

5. Based on review of the clinical records, there must be a deterioration in the EDSS of at least 1 or more points over the previous 4 years (or less).

6. Eligibility criteria confirmed by the Eligibility Review Group (Appendix 10)

7. Recipients who have been treated with ocrelizumab, rituximab, ofatumumab, ublituximab, or alemtuzumab must undergo a washout period as described in Appendix 14 prior to their planned day 0.

8. Recipients must be willing to undergo mobilized autologous peripheral blood stem cell collection to create a cryopreserved rescue product prior to alloHCT.

9. Ability to undergo MRI without general anesthesia

10. Ability to undergo all tests and procedures in the study

11. Patients who are not vaccinated for COVID-19 must have no symptoms of COVID-19 and have negative testing for COVID-19. For other vaccine-preventable illnesses, it is recommended that patients are current on their vaccination schedule.

Exclusion Criteria

1. History of Progressive Multifocal Leukoencephalopathy

2. Organ dysfunction or disease that would jeopardize survival after hematopoietic cell transplantation, including but not limited to the following:

1. Renal insufficiency as defined by an estimated GFR <60 mL/minute

2. Cardiac dysfunction as defined by symptomatic coronary artery disease, congestive heart failure, valvular heart disease, cardiomyopathy, uncontrolled arrhythmia(s), or left ventricular ejection fraction <50%. Participants with a history of these conditions may enroll if they are demonstrated to have optimal cardiac function (as defined by echocardiography or multi-gated acquisition scan)

3. Pulmonary dysfunction that poses a risk of mortality after transplant, defined as pre-transplant pulmonary function testing demonstrating a FEV1 <70% expected and/or a DLCOadj <70% expected.

4. Necroinflammatory or fibrotic liver disease with evidence of liver dysfunction, including but not limited to jaundice, hepatic encephalopathy, or portal hypertension

5. Marrow dysfunction that poses a risk of peri-transplant mortality, defined as an absolute neutrophil count (<1000/mm3) below the lower limit of normal, or a platelet count below 50,000/mm3.

6. Poorly controlled hypertension despite appropriate therapy, defined as a diastolic blood pressure greater than 90 mm Hg while on therapy.

7. Poorly controlled diabetes mellitus, defined as HgbA1c ≥ 6.5% despite therapy or recurrent hypoglycemia while on therapy.

8. Extreme protein-calorie malnutrition defined by Body Mass Index <18 and unintentional weight loss (3 kg in the last month or 6 kg in the last 6 months.)

3. History of smoking either tobacco or other herbal products in the last 3 months.

4. Planned pharmaceutical in vivo or ex vivo T cell depletion (TCD), eg, cladribine, or peritransplant antithymocyte globulin (ATG). For participants who have previously been exposed to a TCD agent, a 5-half-life washout of the agent must occur prior to planned day 0 (day 0 is defined as the day of infusion Orca-Q Prime). The washout period for alemtuzumab is listed in Appendix 14.

5. HIV seropositive.

6. HBV serology results indicating chronic HBV infection per https://www.cdc.gov/hepatitis/hbv/interpretationOfHepBSerologicResults.htm, unless HBV PCR negative. HBV seropositive participants should be on antiviral therapy after transplant.

7. HCV seropositive, unless PCR negative and having undergone 'curative' antiviral therapy.

8. Participant has active uncontrolled infection

9. Participant has demonstrated lack of compliance with prior medical care

10. Participants with known active malignancy. It is recommended that patients are current on cancer screening tests for their age and family history as per the NCCN [The National Comprehensive Cancer Network®] Guidelines. Screening should be performed, if indicated, per NCCN guidelines prior to study treatment.

11. Participants whose life expectancy is severely limited by illness other than multiple sclerosis

12. Females who are pregnant or breast feeding.

13. Medical or psychiatric conditions that compromise ability to give informed consent or to comply with treatment protocol

14. Inability to undergo an MRI scan

15. Currently receiving treatment with investigational agents

16. Positive for JC virus DNA in the CSF or blood during screening.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Orca Biosystems, Inc.

INDUSTRY

Sponsor Role: collaborator

Stanford University

OTHER

Sponsor Role: lead

Responsible Party

Everett Meyer

Associate Professor of Medicine

Responsibility Role: PRINCIPAL_INVESTIGATOR

Central Contacts

Multiple Sclerosis and Neuroimmunology Study Team

Role: CONTACT

neuroimmunologyresearch@stanford.edu

650-319-5522

Other Identifiers

75412

Identifier Type: -

Identifier Source: org_study_id