Association Between CGM Metrics in Type 2 Diabetes Pregnancy and Perinatal Morbidity

NCT ID: NCT06892314

Last Updated: 2025-12-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

80 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-05-15

Study Completion Date

2025-11-26

Brief Summary

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The purpose of this observational study is to measure the association between continuous glucose monitoring (CGM) parameters and perinatal morbidity in offspring of women with type 2 diabetes. Specifically, the study will assess whether gestational age interacts with metabolic control in influencing perinatal morbidity, as well as the impact of the timing of CGM initiation during pregnancy.

Detailed Description

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Continuous glucose monitoring (CGM) data in pregnant women living with type 2 diabetes (T2D) and its association with perinatal morbidity are very recent and remain scarce. Moreover, perinatal morbidity appears to differ in these patients compared to pregnancies affected by type 1 diabetes or gestational diabetes.

As a result, a deeper understanding is needed to identify the most relevant glycemic parameters and, in particular, the gestational age most critical for metabolic control.

Furthermore, uncertainty remains regarding the benefits of early CGM use in this population, which is characterized by early-onset T2D. A description of this population in the French context is therefore of particular interest.

This single-centre observational study will consist of a retrospective cohort of patients with type 2 diabetes and pregnancy with pregnancy follow-up and delivery at the Centre Hospitalier Sud-Francilien between 1 January 2020 and 31 January 2025.

Conditions

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Type 2 Diabetes Mellitus (T2DM) Pregnancy

Keywords

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Type 2 diabetes mellitus Continuous glucose monitoring Pregnancy Retrospective cohort study

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Patients

Exposure to hyperglycemia (type 2 diabetes)

Intervention Type BIOLOGICAL

Exposure to hyperglycemia, in the context of type 2 diabetes, as measured by continuous glucose monitoring

Interventions

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Exposure to hyperglycemia (type 2 diabetes)

Exposure to hyperglycemia, in the context of type 2 diabetes, as measured by continuous glucose monitoring

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* Adult patient
* Patient diagnosed with type 2 diabetes before or during pregnancy (fasting blood glucose \> 126 mg/dL, blood glucose \> 200 mg/dL after an oral glucose tolerance test, or HbA1c \> 6.5%)
* Patient who has undergone continuous glucose monitoring at least once during pregnancy

Exclusion Criteria

* Multiple pregnancy
* Pregnancy terminated before 20 weeks of amenorrhea
* Delivery outside CHSF
* Patient and/or legal guardians of the newborn who objected to the use of data
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Centre Hospitalier Sud Francilien

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Coralie AMADOU, MD

Role: PRINCIPAL_INVESTIGATOR

Centre Hospitalier Sud Francilien

Locations

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Centre Hospitalier Sud Francilien

Corbeil-Essonnes, France, France

Site Status

Countries

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France

Other Identifiers

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2025/0006

Identifier Type: -

Identifier Source: org_study_id