Pregnancy and Childbirth in Women with Thalassemia Yesterday and Today

NCT ID: NCT06889727

Last Updated: 2025-03-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

75 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-08-09

Study Completion Date

2024-05-14

Brief Summary

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Recent advances in the management of thalassemia have significantly improved life expectancy and quality of life of patients with this hemoglobinopathy, with a consequent increase in their reproductive potential and desire to have children.Since an initial report of a successful pregnancy in a woman with thalassemia major by Walker in 1969, hundreds of pregnancies have been reported so far, highlighting that women carefully managed in the preconception phase usually carry out a successful gestation and labor, both in case of spontaneous conception and assisted reproductive techniques.

Detailed Description

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Conditions

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Thalassemia

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Transfusion dependent and nontransfusion- dependent thalassemia
* Pregnancy ended with the birth of a live or dead foetus
* Pregnancy ended in miscarriage or voluntary abortion
* Pregnancy in progress

Exclusion Criteria

* Other types of anemia
* Pregnancy not initiated despite assisted fertilization practices
* Subjects unwilling to sign informed consent
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Fondazione per la Ricerca sulle Anemie ed Emoglobinopatie in Italia

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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UniversityCagliari, OspPed Microcitemico, Cagliari

Cagliari, CAGLIARI, Italy

Site Status

Countries

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Italy

Other Identifiers

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GRAV001

Identifier Type: -

Identifier Source: org_study_id

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