Thromboelastography to Study Burn Coagulopathy

NCT ID: NCT06879509

Last Updated: 2025-03-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

50 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-06-30

Study Completion Date

2025-08-31

Brief Summary

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This pilot study examines the use of thromboelastography (TEG), a specialized blood test, to evaluate clotting abnormalities in burn patients. The study aims to understand how burn injuries impact the body's ability to form and break down blood clots over time. Specifically, the investigators will research whether the percentage of total body surface area burned (%TBSA) is associated with changes in blood clotting, track the evolution of clotting patterns during the first four weeks following a burn injury, and explore whether these changes can predict recovery or complications. By providing new insights into clotting dynamics in burn patients, the study seeks to improve diagnostic methods, enhance monitoring strategies, and guide treatments to optimize patient care and outcomes.

Detailed Description

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Conditions

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Burn Coagulation, Blood

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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Burn Thromboelastography Group

Overall study population (all participants are in the same group). See eligibility for further details.

Group Type EXPERIMENTAL

Thromboelastography

Intervention Type DIAGNOSTIC_TEST

All participants will receive this intervention. Thromboelastography (TEG) is a blood test that provides a detailed assessment of the clotting process, measuring how blood clots form, strengthen, and dissolve. It offers real-time insights into a patient's coagulation status, helping to identify clotting disorders and guide treatment decisions.

Interventions

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Thromboelastography

All participants will receive this intervention. Thromboelastography (TEG) is a blood test that provides a detailed assessment of the clotting process, measuring how blood clots form, strengthen, and dissolve. It offers real-time insights into a patient's coagulation status, helping to identify clotting disorders and guide treatment decisions.

Intervention Type DIAGNOSTIC_TEST

Other Intervention Names

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TEG

Eligibility Criteria

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Inclusion Criteria

* Patients admitted with acute burn injuries
* Aged 18 years and older
* Provided consent to participate in the study

Exclusion Criteria

* Patients with a history of venous thromboembolism or hyper/hypocoagulopathy
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Francesco Egro

OTHER

Sponsor Role lead

Responsible Party

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Francesco Egro

Associate Professor

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Francesco M Egro, MD, MSc, MRCS

Role: PRINCIPAL_INVESTIGATOR

Department of Plastic Surgery, University of Pittsburgh Medical Center

Locations

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University of Pittsburgh Medical Center

Pittsburgh, Pennsylvania, United States

Site Status

Countries

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United States

Central Contacts

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Francesco M Egro, MD

Role: CONTACT

(404) 861-7944‬

Hilary Y Liu, BS

Role: CONTACT

4846315188

Facility Contacts

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Francesco M Egro, MD

Role: primary

(404) 861-7944‬

Hilary Y Liu, BS

Role: backup

4846315188

References

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Baumeister S, Koller M, Dragu A, Germann G, Sauerbier M. Principles of microvascular reconstruction in burn and electrical burn injuries. Burns. 2005 Feb;31(1):92-8. doi: 10.1016/j.burns.2004.07.014.

Reference Type BACKGROUND
PMID: 15639372 (View on PubMed)

Alessandri-Bonetti M, Kasmirski JA, Liu HY, Corcos AC, Ziembicki JA, Stofman GM, Egro FM. Impact of Microsurgical Reconstruction Timing on the Risk of Free Flap Loss in Acute Burns: Systematic Review and Meta-Analysis. Plast Reconstr Surg Glob Open. 2024 Aug 9;12(8):e6025. doi: 10.1097/GOX.0000000000006025. eCollection 2024 Aug.

Reference Type BACKGROUND
PMID: 39129846 (View on PubMed)

Other Identifiers

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STUDY23120009

Identifier Type: -

Identifier Source: org_study_id

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