Social Cognition in Dystrophinopathies and Neurodevelopmental Disorders
NCT ID: NCT06874166
Last Updated: 2025-03-13
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
45 participants
OBSERVATIONAL
2025-09-30
2027-12-31
Brief Summary
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The secondary aim is to study cortical activity at rest, by means of electroencephalography (EEG), to explore frequencies and time course of EEG responses. Moreover, the relationship between EEG activity and neuropsychological, dispositional and subjective measures will be explored through correlational analyses.
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Detailed Description
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All the tasks will be performed in a counterbalanced order, for an overall duration of about 40 minutes.
4\. Recording of resting state EEG will be collected.
Conditions
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Study Design
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CASE_CONTROL
CROSS_SECTIONAL
Study Groups
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BMD/DMD group
Patients diagnosed with Duchenne and Becker muscular dystrophy (genetic and histological diagnosis and clinical diagnosis) (ambulant and non-ambulant), over the age of four.
Electroencephalography (EEG)
Recording of resting state EEG will be collected
Social Cognition Tasks
Comfort-Distance Task: it will be used to measure the interpersonal comfort distance, the task will be implemented in immersive virtual reality environment Interoception will be measured through an auditory match task based on participants heart-beat A measure emotion processing will be collected through the emotion priming visual task, participants will be asked to detect trial by trial the target emotion which could be preceded by a congruent or incongruent visual priming
OI group
Patients diagnosed with osteogenesis imperfecta, over the age of four.
Electroencephalography (EEG)
Recording of resting state EEG will be collected
Social Cognition Tasks
Comfort-Distance Task: it will be used to measure the interpersonal comfort distance, the task will be implemented in immersive virtual reality environment Interoception will be measured through an auditory match task based on participants heart-beat A measure emotion processing will be collected through the emotion priming visual task, participants will be asked to detect trial by trial the target emotion which could be preceded by a congruent or incongruent visual priming
Control group
Participants without any neurological or psychiatric disorder, over the age of four.
Electroencephalography (EEG)
Recording of resting state EEG will be collected
Social Cognition Tasks
Comfort-Distance Task: it will be used to measure the interpersonal comfort distance, the task will be implemented in immersive virtual reality environment Interoception will be measured through an auditory match task based on participants heart-beat A measure emotion processing will be collected through the emotion priming visual task, participants will be asked to detect trial by trial the target emotion which could be preceded by a congruent or incongruent visual priming
Interventions
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Electroencephalography (EEG)
Recording of resting state EEG will be collected
Social Cognition Tasks
Comfort-Distance Task: it will be used to measure the interpersonal comfort distance, the task will be implemented in immersive virtual reality environment Interoception will be measured through an auditory match task based on participants heart-beat A measure emotion processing will be collected through the emotion priming visual task, participants will be asked to detect trial by trial the target emotion which could be preceded by a congruent or incongruent visual priming
Eligibility Criteria
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Inclusion Criteria
* Patients diagnosed with osteogenesis imperfecta.
* Control group: participants without any neurological or psychiatric disorder
Exclusion Criteria
* sensory deficit
* specific condition that could prevent the application of the tests and tasks under study, such as: a) the need for PEG; b) the need for tracheostomy; c) the need for assisted ventilation.
* cognitive level lower than 60.
4 Years
MALE
Yes
Sponsors
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IRCCS Eugenio Medea
OTHER
Responsible Party
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Central Contacts
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Other Identifiers
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L2-227
Identifier Type: -
Identifier Source: org_study_id
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