Neuropathic Pain and Traditional Medicine Syndromes in Herpes Zoster: a Cross-Sectional Study

NCT ID: NCT06870877

Last Updated: 2025-03-11

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Total Enrollment: 80 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2025-02-28
• Study Completion Date: 2025-05-12

Brief Summary

This study investigates the relationship between neuropathic pain characteristics and Traditional Chinese Medicine (TCM) syndromes in patients with Herpes Zoster (HZ). The study aims to integrate objective pain assessment tools, such as the Leeds Assessment of Neuropathic Symptoms and Signs (LANSS) scale, with TCM diagnostic classifications to enhance individualized treatment strategies. Conducted at Le Van Thinh Hospital, Vietnam, this cross-sectional study includes 80 HZ patients, assessing their pain levels and corresponding TCM syndromes. The findings will contribute to a more comprehensive approach to pain management in Herpes Zoster.

Detailed Description

This study is a cross-sectional and case series study conducted at Le Van Thinh Hospital, Ho Chi Minh City, Vietnam, between January and June 2024. It aims to evaluate the correlation between neuropathic pain characteristics and Traditional Chinese Medicine (TCM) syndromes in patients with Herpes Zoster (HZ). The study includes 80 participants diagnosed with HZ, whose pain severity is assessed using the Leeds Assessment of Neuropathic Symptoms and Signs (LANSS) scale. The participants are classified into TCM syndromes based on standard diagnostic criteria, including Liver Meridian Depression and Heat Syndrome (LMD), Spleen Deficiency and Dampness Retention Syndrome (SDA), and Qi Stagnation and Blood Stasis Syndrome (QSA).

The primary objectives of the study are:

To determine the prevalence of different TCM syndromes in HZ patients. To analyze the correlation between LANSS scores and specific TCM syndromes. To provide insights into the integration of objective neuropathic pain assessment tools with traditional diagnostic frameworks.

Data collection includes demographic characteristics, medical history, pain characteristics, TCM diagnostic features, and clinical examination results. Statistical analyses include correlation tests and multinomial logistic regression to assess the relationship between LANSS pain scores and TCM syndromes.

The study findings will contribute to a better understanding of the relationship between neuropathic pain and TCM syndromes in Herpes Zoster. The results may help refine diagnostic approaches and optimize integrative treatment strategies for pain management in patients with HZ.

Conditions

Herpes Zoster (HZ); Traditional Chinese Medicine (TCM)

Study Design

• Observational Model Type: OTHER
• Study Time Perspective: CROSS_SECTIONAL

Eligibility Criteria

Inclusion Criteria

• Adults aged ≥18 years
• Clinically diagnosed with Herpes Zoster (HZ) based on European Consensus Guidelines
• Experiencing neuropathic pain associated with HZ
• Willing to provide informed consent

Exclusion Criteria

• History of chronic pain conditions unrelated to HZ
• Receiving immunosuppressive therapy or diagnosed with immunodeficiency disorders
• Patients who had already received antiviral or analgesic treatment before evaluation
• Patients unable or unwilling to provide informed consent

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Do Thanh Sang

OTHER

Sponsor Role: lead

Responsible Party

Do Thanh Sang

University of Medicine and Pharmacy at Ho Chi Minh City

Responsibility Role: SPONSOR_INVESTIGATOR

Locations

Le Van Thinh Hospital

Ho Chi Minh City, Viet Nam, Vietnam

Countries

Vietnam

Facility Contacts

Sang Do, MD

Role: primary

dtsang@ump.edu.vn

+84 28 3896 9990

Sang Do

Role: backup

Other Identifiers

78/HĐĐĐ-ĐHYD

Identifier Type: -

Identifier Source: org_study_id