The Value of PET Imaging Targeting Granzyme B in Predicting Efficacy and Prognosis in T-NK Cell Lymphoma

NCT ID: NCT06863441

Last Updated: 2025-03-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-03-01

Study Completion Date

2029-12-31

Brief Summary

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The study on the value of PET imaging targeting granzyme B in predicting the efficacy and prognosis of T-NK cell lymphoma.

Detailed Description

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The investigators will number all participants, create a medical record file, and record their basic information (gender, age) as well as contact information and medical history information. All participants will undergo 68Ga-grazytracer PET at baseline and after one course of immunotherapy.

Conditions

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T-NK Cell Lymphoma

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Study Groups

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patients diagnosed with T-NK cell lymphoma who will receive immunotherapy

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

1. Age \> 18 years, regardless of gender.
2. Histopathologically confirmed diagnosis of T-NK cell lymphoma.
3. Newly diagnosed and untreated patients or refractory/relapsed patients preparing to undergo immunotherapy.
4. Availability of complete clinicopathological and follow-up data.
5. Signed and dated informed consent form.

Exclusion Criteria

1. Patients who have previously received anti-tumor therapy.
2. Patients with a history of other malignancies.
3. Incomplete clinical information or imaging data.
4. Concurrent other malignant tumors.
5. Patients with severe medical conditions deemed unsuitable for participation in this clinical study by the investigator, such as severe cardiopulmonary insufficiency or severe hepatic and renal dysfunction.
6. Poor compliance.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Ruijin Hospital

OTHER

Sponsor Role lead

Responsible Party

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LI BIAO

chief physician

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Ruijin Hospital Affiliated to Shanghai Jiao Tong University Medical School, Shanghai

Shanghai, Shanghai Municipality, China

Site Status

Countries

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China

Central Contacts

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Xinyu Zhang

Role: CONTACT

15958022176

Facility Contacts

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Biao Li

Role: primary

13661777388

Other Identifiers

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RuijinH 2025-34

Identifier Type: -

Identifier Source: org_study_id

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