Efficacy of NSAID Peritendinous Injection for Acute Tendinitis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-02-10

Study Completion Date

2026-03-01

Brief Summary

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This study evaluates whether NSAID peritendinous or ligament injections at acute sprain sites can relieve pain and restore function.

Forty patients will be randomly assigned to either the injection or oral NSAID group. Pain will be assessed subjectively using the Numeric Pain Rating Scale and objectively through pressure pain threshold measurements. Functional outcomes (DASH for the upper limb, FADI for the lower limb) will be evaluated before treatment and at 3 days, 1 week, and 4 weeks post-treatment.

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Detailed Description

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Acute tendon inflammation is a common sports injury, typically treated with oral or topical non-steroidal anti-inflammatory drugs (NSAIDs) or local corticosteroid injections at the affected site. Direct corticosteroid injections provide the fastest relief; however, the World Anti-Doping Agency (WADA) has restricted the use of corticosteroids by any route in its latest banned substance list. As a result, corticosteroid injections into tendons or joints, which were previously allowed during competitions, can no longer be used. Currently, the only methods available for acute inflammation relief during competitions are oral NSAIDs and ice therapy. For athletes without structural damage who need to quickly reduce inflammation and return to play, these methods may be insufficient.

Previous clinical studies on NSAID injections into tendons and joints have shown that local NSAID injections are equally effective as corticosteroid injections for treating shoulder impingement syndrome and knee osteoarthritis. However, these studies mainly focused on patients with chronic arthritis and tendinitis. The difference in efficacy between oral NSAIDs and tendon injections during the acute phase of inflammation remains unknown. This study aims to compare different routes of NSAID administration to identify the most appropriate treatment for managing acute tendinitis in high-level athletes.

We hypothesize that peritendinous NSAID injections will provide greater pain relief and functional improvement.

Conditions

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Tendinitis Acute Tendonitis NSAID (Non-Steroidal Anti-Inflammatory Drug)

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Caregivers Outcome Assessors

Study Groups

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Intervention group

Local anesthetics and NSAID(parecoxib) peritendinous Injection for acute tendinitis

Group Type EXPERIMENTAL

Peritendinous NSAID injection

Intervention Type DRUG

Peritendinous NSAID (parecoxib) injection

Control group

Local anesthetics and normal saline peritendinous injection for acute tendinitis

Group Type PLACEBO_COMPARATOR

Control group (placebo)

Intervention Type DRUG

Normal saline mixed with local anesthetics injection

Interventions

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Peritendinous NSAID injection

Peritendinous NSAID (parecoxib) injection

Intervention Type DRUG

Control group (placebo)

Normal saline mixed with local anesthetics injection

Intervention Type DRUG

Other Intervention Names

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NSAID injection Sham injection

Eligibility Criteria

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Inclusion Criteria

* Ultrasonography diagnosed acute tendinitis with inflammation
* 20-70 years old

Exclusion Criteria

* Cognitive impairment.
* Post operation at painful site.
* Neuropathic pain or vascularity disease
* Unable to receive injection therapy, including a history of syncope during injection.
* Allergy history to NSAID
* Within 14 days after coronary artery bypass graft, CABG

Minimum Eligible Age

20 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No