Transcutaneous Auricular Vagus Nerve Stimulation for Treating Post-stroke Dysphagia

NCT ID: NCT06827301

Last Updated: 2025-02-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-11-23

Study Completion Date

2026-06-30

Brief Summary

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The aim of the present project is to use transcutaneous auricular vagus nerve stimulation (t-VNS) for the treatment of dysphagia in acute stroke patients to improve swallowing function and reduce mortality and disability related to this condition.

30 patients will be randomized into one of the two arms of the study:

* REAL: real t-VNS + speech therapy
* SHAM: t-VNS placebo + speech therapy. The experimental treatment consists in the association between t-VNS (real or placebo) and speech therapy exercises to improve swallowing functionality. Each patient will undergo a speech therapy rehabilitation session lasting approximately 40 minutes a day for 3 consecutive days, simultaneously with t-VNS on left ear.

Swallowing function and clinical conditions will be evaluated before the intervention (baseline, T0), immediately after the intervention (T1) and 3 months after the intervention (T2).

Detailed Description

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Conditions

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Dysphagia Following Cerebrovascular Accident

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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Real t-VNS

real t-VNS on left ear for 40 minutes, daily for 3 consecutive days, simultaneously with speech therapy.

Group Type EXPERIMENTAL

Non Invasive vagus nerve stimulation

Intervention Type DEVICE

Transcutaneous Auricular Vagus Nerve Stimulation

Sham t-VNS

sham t-VNS on left ear for 40 minutes, daily for 3 consecutive days, simultaneously with speech therapy.

Group Type ACTIVE_COMPARATOR

Non Invasive vagus nerve stimulation

Intervention Type DEVICE

Transcutaneous Auricular Vagus Nerve Stimulation

Interventions

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Non Invasive vagus nerve stimulation

Transcutaneous Auricular Vagus Nerve Stimulation

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Acute ischemic or hemorrhagic stroke (within 7 days of onset)
* Dysphagia diagnosed by FEES with a Fiberoptic Endoscopic Dysphagia Severity Scale (FEDSS) score between 3 and 5

Exclusion Criteria

* Pre-existing stroke dysphagia
* Dementia or other medical conditions that may interfere with the study
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Campus Bio-Medico University

OTHER

Sponsor Role lead

Responsible Party

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Di Lazzaro Vincenzo

Prof

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Università Campus Bio-Medico di Roma

Roma, RM, Italy

Site Status RECRUITING

Countries

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Italy

Central Contacts

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Fioravante Capone, PhD

Role: CONTACT

06225411220

Fabio Pilato, MD

Role: CONTACT

Facility Contacts

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Vincenzo Di Lazzaro

Role: primary

+3906225411220

Other Identifiers

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LOGIC

Identifier Type: -

Identifier Source: org_study_id

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