Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
15 participants
INTERVENTIONAL
2025-05-01
2025-06-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
DOUBLE
Study Groups
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Active TMS, Sham TMS
Participants will receive 2 sessions of Transcranial Magnetic Stimulation (TMS) delivered using standard intermittent theta-burst (iTBS) parameters (600 pulses, 3 min, 120% rMT). Participants will receive, on separate sessions, either active or sham iTBS delivered during pre-sleep wakefulness or NREM sleep stages while recording with Electroencephalography (EEG). Participants will perform the N-back task and Multi-source Interference Task (MSIT) during each session to measure working memory and cognitive control performance.
TMS
Transcranial magnetic stimulation (TMS) applies magnetic pulses to stimulate nerve cells in the brain.
Sham TMS, Active TMS
Participants will receive 2 sessions of Transcranial Magnetic Stimulation (TMS) delivered during using standard intermittent theta-burst (iTBS) parameters (600 pulses, 3 min, 120% rMT). Participants will receive, on separate sessions, either active or sham iTBS delivered during pre-sleep wakefulness or NREM sleep stages while recording with Electroencephalography (EEG). Participants will perform the N-back task and Multi-source Interference Task (MSIT) during each session to measure working memory and cognitive control performance.
TMS
Transcranial magnetic stimulation (TMS) applies magnetic pulses to stimulate nerve cells in the brain.
Interventions
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TMS
Transcranial magnetic stimulation (TMS) applies magnetic pulses to stimulate nerve cells in the brain.
Eligibility Criteria
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Inclusion Criteria
* Failed \>= 1 antidepressant medication
* Moderate-to-severe depression
Exclusion Criteria
* Significant head injury/neurological disorder
* Pregnancy or postpartum
* TMS/MRI contraindications
* Active substance use/suicidal ideation
18 Years
65 Years
ALL
No
Sponsors
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National Center for Advancing Translational Sciences (NCATS)
NIH
Stanford University
OTHER
Responsible Party
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Corey Keller
Associate Professor in Department of Psychiatry and Behavioral Sciences
Principal Investigators
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Corey J Keller, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
Stanford University
Locations
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Stanford University
Stanford, California, United States
Countries
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Other Identifiers
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60980-3
Identifier Type: -
Identifier Source: org_study_id
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