Thyroid Dysfunction Induced by Radiotherapy Treatment in Patients with Breast Cancer
NCT ID: NCT06820554
Last Updated: 2025-02-11
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
NOT_YET_RECRUITING
97 participants
OBSERVATIONAL
2025-03-01
2026-05-01
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
However, RT-induced toxicities to adjacent normal tissues can lead to serious morbidity in cancer survivors .
The thyroid regulates the body's metabolism via producing thyroxine (T4) and triiodothyronine (T3) hormones. As the thyroid is sensitive to RT, radiation-induced thyroid disorders have been reported in cancer patients who received radiation in the cervical or SCV regions .
In breast cancer patients, RT to the SCV area has been associated with a higher incidence of Hypothyriodism, particularly in younger patients This complication may be associated with radiation-induced thyroid volume reduction .
Recent studies,have reported a significant decrease in thyroid volume (14-30 %) in patients with laryngeal or nasopharyngeal carcinoma (NPC), suggesting an association between HT and post-RT thyroid atrophy .
Little is known about the changes of thyroid gland volume based on local thyroid gland radiation dose and its correlations with incidence of HT.
Our study aim the changes in thyroid volume of breast cancer patients who received RT to the SCV nodal area, to evaluate RT-induced thyroid gland evolution based on local radiation dose. We then assessed the association between thyroid volume changes and the incidence of post-RT Hypothyrodism in breast cancer patients.
the aim of the study to diagnose subclinical hypothyroidism and biochemical changes in thyroid function after radiotherapy for breast cancer
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
A Randomized Comparison of Radiation Therapy Techniques in the Management of Node Positive Breast Cancer
NCT00581256
Postoperative Radiation of Patients With Breast Cancer in Extreme Hypofractionation.
NCT05452083
Acute and Long-term Cardiovascular Toxicity After Modern Radiotherapy for Breast Cancer
NCT02541435
Radiotherapy After Mastectomy for Breast Cancer Patients at Increased Risk of Local Recurrence
NCT03101683
Hypofractionated Irradiation At Regional Nodal Area for Breast Cancer Vs Existed Standard Treatment
NCT03829553
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
However, RT-induced toxicities to adjacent normal tissues can lead to serious morbidity in cancer survivors .
The thyroid regulates the body's metabolism via producing thyroxine (T4) and triiodothyronine (T3) hormones. As the thyroid is sensitive to RT, radiation-induced thyroid disorders have been reported in cancer patients who received radiation in the cervical or SCV regions .
In breast cancer patients, RT to the SCV area has been associated with a higher incidence of Hypothyriodism, particularly in younger patients This complication may be associated with radiation-induced thyroid volume reduction .
Recent studies,have reported a significant decrease in thyroid volume (14-30 %) in patients with laryngeal or nasopharyngeal carcinoma (NPC), suggesting an association between HT and post-RT thyroid atrophy .
Little is known about the changes of thyroid gland volume based on local thyroid gland radiation dose and its correlations with incidence of HT.
Our study aim the changes in thyroid volume of breast cancer patients who received RT to the SCV nodal area, to evaluate RT-induced thyroid gland evolution based on local radiation dose. We then assessed the association between thyroid volume changes and the incidence of post-RT Hypothyrodism in breast cancer patients.
the aim of the study to diagnose subclinical hypothyroidism and biochemical changes in thyroid function after radiotherapy for breast cancer
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
COHORT
PROSPECTIVE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
brest cancer
breast cancer patients who will be indicated for postoperative ( mastectomy /BCT) adjuvant radiotherapy who are\>18 yrs old breast cancer ( pathological proved ) Stage II/III breast cancer High risk local recurrence ( LVI/ G3/ LN positive) Non metastatic breast cancer
No interventions assigned to this group
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* Stage II/III breast cancer
* High risk local recurrence ( LVI/ G3/ LN positive)
* Non metastatic breast cancer
Exclusion Criteria
18 Years
ALL
No
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
Assiut University
OTHER
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
fatmaelzahraa mohamed said
residant doctor
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
TD radio brest cancer
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.