Prospective Analysis of Circulating Nucleosomes in Patients Receiving a First Line Treatment for a Non-Hodgkin Lymphoma

NCT ID: NCT06813573

Last Updated: 2025-02-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

50 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-09-30

Study Completion Date

2029-10-31

Brief Summary

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The goal of this study is to prospectively follow the level of circulating nucleosomes in patients treated for a non-Hodgkin lymphoma and determine whether it correlates with the clinical response.

Detailed Description

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Conditions

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Follicular Lymphoma Diffuse Large B-Cell Lymphoma

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Patients receiving first line of treatment with a RCHOP 21 regimen

All patients will receive first line of treatment with a RCHOP 21 regimen

Group Type EXPERIMENTAL

blood sampling

Intervention Type BIOLOGICAL

A maximum of 4 tubes of 10ml will be collected: at baseline (before cycle 1), before each cycle (from 2 to 6 included), at the end of the treatment, and in case of relapse during follow-up period

Interventions

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blood sampling

A maximum of 4 tubes of 10ml will be collected: at baseline (before cycle 1), before each cycle (from 2 to 6 included), at the end of the treatment, and in case of relapse during follow-up period

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* Histologically proven diagnosis of diffuse large B cell lymphoma or follicular lymphoma, according to the WHO 2016 classification, requiring a first line of treatment with a RCHOP 21 regimen
* Agreement to participate after receiving oral and written information on the study

Exclusion Criteria

* History of previous treatment for lymphoma (excluding localized low dose radiotherapy in the case of follicular lymphoma)
* Treatment with a chemotherapy regimen different from RCHOP21
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Gustave Roussy, Cancer Campus, Grand Paris

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Gustave Roussy

Villejuif, , France

Site Status RECRUITING

Countries

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France

Central Contacts

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David GHEZ

Role: CONTACT

+33 1 42 11 42 40

Christophe MARZAC

Role: CONTACT

+33 1 42 11 51 31

Facility Contacts

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David GHEZ

Role: primary

+33 1 42 11 42 40

Other Identifiers

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2023-3670

Identifier Type: OTHER

Identifier Source: secondary_id

2023-A02716-39

Identifier Type: -

Identifier Source: org_study_id

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