Teicoplanin Allergy Testing Using Autologous Serum (TATAS)
NCT ID: NCT06803758
Last Updated: 2025-01-31
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
20 participants
INTERVENTIONAL
2025-01-08
2026-12-31
Brief Summary
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The patients which we recruit to our study will come to us through the perioperative allergy service. They will have had a reaction to a general anaesthetic, but will also have had teicoplanin as part of the anaesthetic.
We are not sure why allergy skin testing, which is fairly reliable for most other drugs, is so unreliable in detecting teicoplanin allergy. We do know that some drugs need to mix with proteins in the blood before they trigger an allergy. We would like to replicate this by mixing the teicoplanin with the patients' own blood and using this for the skin testing, to see if we get a more reliable result compared with the plain drug. Using the patient's own serum to do skin testing is an established test (the 'autologous serum test') used in certain immunological conditions, we are simply going to use it as a vehicle to test our theory.
We will recruit 20 adult patients referred with a recent history of anaphylaxis under anaesthesia, where teicoplanin has been given and is one of the drugs under suspicion of having caused the allergy. In addition to the usual allergy skin testing, which would be done anyway as part of standard allergy investigation, we will perform extra tests using autologous serum for this trial.
We hope to find a better way of testing for Teicoplanin allergy, so that patients are not put at risk where the allergy has been missed because of an unreliable test.
Detailed Description
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Conditions
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Keywords
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Study Design
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NA
SINGLE_GROUP
OTHER
NONE
Study Groups
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Teicoplanin allergy testing using autologous serum
20 adult patients with history of anaphylaxis under anaesthesia ( the index episode), where teicoplanin has been given during the index episode will be recruited. In addition to usual skin testing with Teicoplanin directly onto the skin, we will perform skin testing with Teicoplanin- added autologous serum. The trial will be conducted as part of the same routine elective allergy skin-testing appointment for other drugs given during the index episode.
Teicoplanin Allergy Testing using autologous serum
In addition to performing teicoplanin allergy skin testing using standard recommended Teicoplanin concentration, we will perform skin testing using autologous serum, the supernatant which is obtained via centrifugation. Skin testing ( skin prick test and intradermal test) will be performed with these additional samples:
1. STpre: Teicoplanin added to blood sample pre-centrigufation.
2. STpost: Teicoplanin added to supernatant post-centrigufation.
3. ST0: Supernatant with no additives ( serum negative control)
Interventions
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Teicoplanin Allergy Testing using autologous serum
In addition to performing teicoplanin allergy skin testing using standard recommended Teicoplanin concentration, we will perform skin testing using autologous serum, the supernatant which is obtained via centrifugation. Skin testing ( skin prick test and intradermal test) will be performed with these additional samples:
1. STpre: Teicoplanin added to blood sample pre-centrigufation.
2. STpost: Teicoplanin added to supernatant post-centrigufation.
3. ST0: Supernatant with no additives ( serum negative control)
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Pregnancy
* Patients under age 18 years
* Patients with elevated baseline mast cell tryptase requiring further investigation
* Patients with blood-borne viruses such as Hep B, C and HIV
18 Years
ALL
Yes
Sponsors
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University Hospital Southampton NHS Foundation Trust
OTHER
Responsible Party
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Principal Investigators
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Linda Nel, MB BCh FRCA
Role: STUDY_CHAIR
University Hospital Southampton NHS Foundation Trust
Locations
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University Hospital Southampton
Southampton, , United Kingdom
Countries
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Central Contacts
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Facility Contacts
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Linda Nel, MB BCh, FRCA
Role: primary
Xi Ying Soo, MBBS, MRCP(UK)
Role: backup
References
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Liccardi G, D'Amato G, Canonica GW, Salzillo A, Piccolo A, Passalacqua G. Systemic reactions from skin testing: literature review. J Investig Allergol Clin Immunol. 2006;16(2):75-8.
Savic LC, Garcez T, Hopkins PM, Harper NJ, Savic S. Teicoplanin allergy - an emerging problem in the anaesthetic allergy clinic. Br J Anaesth. 2015 Oct;115(4):595-600. doi: 10.1093/bja/aev307.
Related Links
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Autologous serum skin test reactions in chronic spontaneous urticaria differ from heterologous cell reactions
BSACI Standard Operating Procedures- Skin Prick Test
Emergency treatment of anaphylaxis
Other Identifiers
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345535
Identifier Type: OTHER
Identifier Source: secondary_id
RHM CRI0456
Identifier Type: -
Identifier Source: org_study_id