Mental Health, Intellectual and Neurodevelopmental Disorder Detection With Artificial Intelligence Models

NCT ID: NCT06792175

Last Updated: 2025-09-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ENROLLING_BY_INVITATION

Total Enrollment

500 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-02-04

Study Completion Date

2026-07-31

Brief Summary

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This study investigates whether AI-driven analysis of speech can accurately predict clinical diagnoses and assess risk for various mental or behavioral health conditions, including attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder, bipolar disorder, generalized anxiety disorder, major depressive disorder, obsessive compulsive disorder (OCD), post-traumatic stress disorder (PTSD), and schizophrenia. We aim to develop tools that can support clinicians in making more accurate and efficient diagnoses.

Detailed Description

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Conditions

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Autism Spectrum Disorder Depression - Major Depressive Disorder Anxiety, Generalized Bipolar Disorder (BD) Attention Deficit Hyperactivity Disorder (ADHD) Schizophrenia Spectrum &Amp; Other Psychotic Disorders Post Traumatic Stress Disorder Obsessive Compulsive Disorder (OCD)

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Solicue (Any Mental Health Disorder)

Any participant enrolled in the study and not part of additional analysis group.

Solicue Machine Learning Models

Intervention Type DIAGNOSTIC_TEST

A comprehensive machine-learning tool aimed at providing probability estimates for several compatible disorders, including Attention Deficit Hyperactivity Disorder (ADHD), Autism Spectrum Disorder (ASD), Bipolar Affective Disorder (BPAD), Generalized Anxiety Disorder (GAD), Major Depressive Disorder (MDD), Obsessive Compulsive Disorder (OCD), Post-Traumatic Stress Disorder (PTSD), and Schizophrenia Spectrum Disorders (SSD). By offering a multi-diagnostic assessment based on speech analysis, Solicue aims to assist clinicians in navigating this complexity and potentially identifying conditions that might otherwise be overlooked in initial assessments.

Solicue leverages machine learning to analyze a wide range of clinically relevant speech features, including linguistic content, prosodic elements (such as pitch, rhythm, and intonation), and other paralinguistic features.

Solicue & Mercuria (Bipolar Disorder & Major Depressive Disorder)

Any participant enrolled in the study and exhibiting depressive symptoms as measured by PHQ-9 score.

Solicue Machine Learning Models

Intervention Type DIAGNOSTIC_TEST

A comprehensive machine-learning tool aimed at providing probability estimates for several compatible disorders, including Attention Deficit Hyperactivity Disorder (ADHD), Autism Spectrum Disorder (ASD), Bipolar Affective Disorder (BPAD), Generalized Anxiety Disorder (GAD), Major Depressive Disorder (MDD), Obsessive Compulsive Disorder (OCD), Post-Traumatic Stress Disorder (PTSD), and Schizophrenia Spectrum Disorders (SSD). By offering a multi-diagnostic assessment based on speech analysis, Solicue aims to assist clinicians in navigating this complexity and potentially identifying conditions that might otherwise be overlooked in initial assessments.

Solicue leverages machine learning to analyze a wide range of clinically relevant speech features, including linguistic content, prosodic elements (such as pitch, rhythm, and intonation), and other paralinguistic features.

Mercuria Machine Learning Models

Intervention Type DIAGNOSTIC_TEST

Mercuria is designed to stratify the risk of bipolar disorder in individuals presenting with depressive symptoms. This is a critical clinical need, as misdiagnosis of bipolar disorder as unipolar depression is common and can lead to inappropriate treatment, potentially worsening outcomes. By analyzing speech patterns characteristic of bipolar disorder, Mercuria aims to provide an additional tool for clinicians to differentiate between these conditions more accurately, guiding appropriate treatment decisions.

Mercuria leverages machine learning to analyze a wide range of clinically relevant speech features, including linguistic content, prosodic elements (such as pitch, rhythm, and intonation), and other paralinguistic features.

Interventions

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Solicue Machine Learning Models

A comprehensive machine-learning tool aimed at providing probability estimates for several compatible disorders, including Attention Deficit Hyperactivity Disorder (ADHD), Autism Spectrum Disorder (ASD), Bipolar Affective Disorder (BPAD), Generalized Anxiety Disorder (GAD), Major Depressive Disorder (MDD), Obsessive Compulsive Disorder (OCD), Post-Traumatic Stress Disorder (PTSD), and Schizophrenia Spectrum Disorders (SSD). By offering a multi-diagnostic assessment based on speech analysis, Solicue aims to assist clinicians in navigating this complexity and potentially identifying conditions that might otherwise be overlooked in initial assessments.

Solicue leverages machine learning to analyze a wide range of clinically relevant speech features, including linguistic content, prosodic elements (such as pitch, rhythm, and intonation), and other paralinguistic features.

Intervention Type DIAGNOSTIC_TEST

Mercuria Machine Learning Models

Mercuria is designed to stratify the risk of bipolar disorder in individuals presenting with depressive symptoms. This is a critical clinical need, as misdiagnosis of bipolar disorder as unipolar depression is common and can lead to inappropriate treatment, potentially worsening outcomes. By analyzing speech patterns characteristic of bipolar disorder, Mercuria aims to provide an additional tool for clinicians to differentiate between these conditions more accurately, guiding appropriate treatment decisions.

Mercuria leverages machine learning to analyze a wide range of clinically relevant speech features, including linguistic content, prosodic elements (such as pitch, rhythm, and intonation), and other paralinguistic features.

Intervention Type DIAGNOSTIC_TEST

Other Intervention Names

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Solicue Psyrin Speech Analysis Solicue Artificial Intelligence Mercuria Mercuria Artificial Intelligence

Eligibility Criteria

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Inclusion Criteria

1. Participants aged between 16 and 60 years.
2. Individuals currently undergoing or referred for clinical assessment of mental or behavioral health conditions (including but not limited to ADHD, ASD, BPAD, GAD, MDD, OCD, PTSD, SSD)
3. Fluent in English
4. Capable of providing informed consent, or in the case of minors, having a parent or legal guardian who can provide consent on their behalf.
5. Access to a device (smartphone, tablet, or computer) with a microphone and stable internet connectivity, necessary for completing the speech tasks.

Exclusion Criteria

1. Individuals experiencing acute mental health crises or severe symptoms that would preclude meaningful participation in the study, including acute intoxication.
2. Severe cognitive impairment or intellectual disability that would prevent understanding of the study procedures or completion of the speech tasks.
3. Lack of fluency in English.
4. Technical limitations: Inability to access a suitable device or internet connection for completing the speech tasks
Minimum Eligible Age

13 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Allwell Behavioral Health Services

UNKNOWN

Sponsor Role collaborator

The Brookline Center

UNKNOWN

Sponsor Role collaborator

Psyrin Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Julianna Olah, B.Sc., M.A., M.Sc., Ph.D.

Role: PRINCIPAL_INVESTIGATOR

Psyrin Inc.

Atta-ul Raheem R Chaudhry, B.Sc. (Hons.), M.B.B.S.

Role: PRINCIPAL_INVESTIGATOR

Psyrin Inc.

Locations

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The Brookline Center

Brookline, Massachusetts, United States

Site Status

Allwell Behavioral Health Services

Zanesville, Ohio, United States

Site Status

Countries

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United States

Other Identifiers

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PSYRIN-0004

Identifier Type: -

Identifier Source: org_study_id

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