Sympathetic Vascular Transduction Across the Menopause Transition: Contributing Mechanisms
NCT ID: NCT06787066
Last Updated: 2025-09-15
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
EARLY_PHASE1
75 participants
INTERVENTIONAL
2025-07-10
2026-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
BASIC_SCIENCE
NONE
Study Groups
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Women
Women ages 18-70 years will participate.
Propranolol Hydrochloride
Examine how IV propranolol impacts sympathetic transduction
Phentolamine Injection
Examine how IV phentolamine impacts sympathetic transduction
Interventions
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Propranolol Hydrochloride
Examine how IV propranolol impacts sympathetic transduction
Phentolamine Injection
Examine how IV phentolamine impacts sympathetic transduction
Eligibility Criteria
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Inclusion Criteria
* 18-70 years of age
* Body mass index (BMI) \<30 kg/m2
Exclusion Criteria
* Pregnancy, breastfeeding
* Body mass index ≥30 kg/m2
* Oral hormonal contraception in last 6 months, history of hormone replacement therapy, oophorectomy
* Current smoking/nicotine use
* Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy
* Nerve/neurologic disease
* Cardiovascular, hepatic, renal, respiratory disease
* Blood pressure ≥140/90 mmHg
* Diabetes, Polycystic ovarian syndrome
* Communication barriers
* Prescription medications
18 Years
70 Years
FEMALE
Yes
Sponsors
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University of Missouri-Columbia
OTHER
Responsible Party
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Jacqueline K Limberg, PhD
Associate Professor
Locations
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University of Missouri
Columbia, Missouri, United States
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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2125473
Identifier Type: -
Identifier Source: org_study_id
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