A Prospective Epidemiological Study Evaluating Occurrences of Influenza-like Illness

NCT ID: NCT06779981

Last Updated: 2025-06-25

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 119 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2024-12-13
• Study Completion Date: 2025-06-19

Brief Summary

This prospective epidemiological cohort study is being conducted in order to generate epidemiological data in support of Osivax's clinical development of a broad-spectrum influenza vaccine based upon the internal influenza nucleoprotein (NP), i.e., OVX836.

Conditions

Influenza

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

Prospective epidemiological cohort

Urban population of healthy subjects aged 20-64 years, not vaccinated against influenza.

Nasopharyngeal swabs

Intervention Type: OTHER

Completion of an electronic Diary (eDiary) and collection of nasopharyngeal swabs in case the subject experiences ILI symptoms

Interventions

Nasopharyngeal swabs

Completion of an electronic Diary (eDiary) and collection of nasopharyngeal swabs in case the subject experiences ILI symptoms

Intervention Type: OTHER

Other Intervention Names

eDiary

Eligibility Criteria

Inclusion Criteria

1. Written informed consent.

2. Healthy male or female participants, as determined by medical history and medical examination (as needed).

3. Between the ages of 20 and 64 years, inclusive.

4. Reliable and willing to make themselves available for the duration of the study, and willing and able to follow study procedures.

5. Ability and technical possibility for completing an eDiary.

Exclusion Criteria

1. Subjects with a body mass index (BMI) ≤18 kg/m² or ≥35 kg/m²

2. Previous influenza vaccination within 6 months before the day of enrollment or planned to receive during the study duration.

3. Previous vaccination with an mRNA-based influenza vaccine including NP in its composition.

4. Previous administration of OVX836.

5. Pregnant or lactating woman.

6. Females planning to become pregnant or planning to discontinue contraceptive precautions until the end of the trial. Women of childbearing potential (WOCBP) should have appropriate contraceptive methods in place for 2 months before enrolment. Appropriate contraceptive methods are to be maintained until the end of the trial. Please also refer to Appendix A.

7. Past or current history of significant autoimmune diseases, as judged by the Investigator.

8. Current history of uncontrolled medical illness such as diabetes, hypertension, heart, renal or hepatic diseases.

9. Known or suspected infection with human immunodeficiency virus (HIV), hepatitis C virus (HCV), or hepatitis B virus (HBV).

10. Planned administration of any investigational or non-registered product during the entire study period.

11. History of receiving blood, blood components, or immunoglobulins within 3 months prior to the first study visit or planned to receive such product during the whole study period.

12. Behavioral or cognitive impairment, or psychiatric disease that, in the opinion of the Investigator, may interfere with the subject's ability to participate in the study.

13. History of alcohol or drug abuse that ceased less than 6 months before enrolment, current alcohol or drug abuse according to the Investigator's judgement), smoking habit of more than 10 cigarettes/day, or current vaping (nicotine consumption corresponding to more than 10 cigarettes/day).

14. Chronic administration (defined as more than 14 days in total) of immunosuppressants or other immune-modifying drugs during the period starting 3 months before the study vaccine administration. For corticosteroids, this will mean prednisone equivalent ≥20 mg/day. Inhaled, topical and intra-articular steroids are allowed.

15. Individuals with a history of any illness that, in the opinion of the Investigator, could potentially interfere with the results of the study or pose additional risk to the subjects by participating in the study.

16. Sponsor employees or Investigator site personnel directly affiliated with this study and their immediate families. Immediate family is defined as a spouse, parent, child or sibling, whether biological or legally adopted, including children of newly composed families.

• Minimum Eligible Age: 20 Years
• Maximum Eligible Age: 64 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Harmony Clinical Research BVBA

OTHER

Sponsor Role: collaborator

Inferential

INDUSTRY

Sponsor Role: collaborator

University Hospital, Ghent

OTHER

Sponsor Role: collaborator

Osivax

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Centre for Vaccinology (CEVAC)

Ghent, , Belgium

Countries

Belgium

Other Identifiers

OVX-FLU-002

Identifier Type: -

Identifier Source: org_study_id