Phase II Study of Ivonescimab and Cadonilimab in Combination with Chemotherapy in Patients with ES-SCLC

NCT ID: NCT06769971

Last Updated: 2025-01-10

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: PHASE2
• Total Enrollment: 80 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2025-02-01
• Study Completion Date: 2027-12-31

Brief Summary

This is a phase II study. All patients are treatment naive extensive stage small cell lung cancer(ES-SCLC), Eastern Cooperative Oncology Group (ECOG) performance status 0-1. The purpose of this study is to evaluate the efficacy and safety of Ivonescimab and Cadonilimab in combination with chemotherapy in patients with ES-SCLC.

Conditions

Small Cell Lung Cancer

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

ES-SCLC :Ivonescimab and Cadonilimab plus Chemotherapy

Subjects receive Ivonescimab+Cadonilimab + Etoposide+Carboplatin for 4 cycles followed by Ivonescimab and Cadonilimab until progression.

Group Type: EXPERIMENTAL

Ivonescimab

Intervention Type: DRUG

20mg/kg，IV infusion，Day1，Q3W

Cadonilimab

Intervention Type: DRUG

10mg/kg，IV infusion，Day8，Q6W

Etoposide

Intervention Type: DRUG

100mg/kg，IV infusion，Day1-3，Q3W

Carboplatin

Intervention Type: DRUG

AUC 5，IV infusion，Day1，Q3W

Interventions

Ivonescimab

20mg/kg，IV infusion，Day1，Q3W

Intervention Type: DRUG

Cadonilimab

10mg/kg，IV infusion，Day8，Q6W

Intervention Type: DRUG

Etoposide

100mg/kg，IV infusion，Day1-3，Q3W

Intervention Type: DRUG

Carboplatin

AUC 5，IV infusion，Day1，Q3W

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

1.Ability to understand and voluntarily sign a written informed consent form (ICF), which must be signed before the specified study procedures required for the study are performed； 2.18 to 75 years old (at the time of inform consent obtained)； 3.Have an Eastern Cooperative Oncology Group (ECOG) performance status of 0-1； 4.Have a life expectancy of at least 3 months； 5.Have histologically- or cytologically-confirmed diagnosis of Extensive Stage SCLC； 6.Had not received previous systemic therapy; Or ES-SCLC patients who had received definitive chemoradiotherapy for limited-stage small-cell lung cancer but had disease progression > 6 months earlier; 7.Have measurable disease based on Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 assessed by investigator； 8.Be able to provide formalin fixed, paraffin-embedded (FFPE) tumor tissue obtained from either a core or excisional tumor biopsy； 9.Have adequate organ function； 10.All female and male subjects of reproductive potential must agree to use an effective method of contraception, as determined by the Investigator, during and for 120 days after the last dose of study treatment；

Exclusion Criteria

1. Active malignancies within the past 5 years, with the exception of tumors in this study and cured local tumors；

2. Received palliative local treatment, non-specific immunomodulatory treatment within 2 weeks prior to the first dose; and Chinese herbal medicine or traditional Chinese medicinal products with anti-tumor indications within 1 weeks prior to the first dose；

3. Subjects who received any prior treatments targeting the mechanism of tumor immunity；

4. Subjects who received any prior anti-angiogenic therapy；

5. Tumor surrounds important blood vessels or has obvious necrosis, cavitation, or invades surrounding important organs and blood vessels；

6. Active autoimmune disease requiring systemic treatment within 2 years prior to the start of study treatment；

7. Symptomatic metastases of the central nervous system；

8. Presence of clinically symptomatic pleural effusion, pericardial effusion, or ascites requiring frequent drainage；

9. History of perforation of the gastrointestinal tract and/or fistula, history of gastrointestinal obstruction (including incomplete intestinal obstruction requiring parenteral nutrition), extensive bowel resection (partial colectomy or extensive small bowel resection, complicated by chronic diarrhea) within 6 months before the first study drug administration；

10. Has known active Hepatitis B (e.g., HBsAg reactive) or Hepatitis C (e.g., HCV RNA [qualitative] is detected);

11. History of myocardial infarction, unstable angina, cardiac or other vascular stenting, angioplasty, or surgery within 12 months prior to day 1 of study treatment;

12. Severe infection within 4 weeks prior to the first dose, including but not limited to comorbidities requiring hospitalization, sepsis, or severe pneumonia; active infection that has received systemic anti-infective therapy within 2 weeks prior to the first dose (excluding antiviral therapy for hepatitis B or C)；

13. Concurrent enrollment in another clinical study, unless it is a noninterventional clinical study or the follow-up period of the interventional study is more than 4 weeks from the last dose of the prior clinical study or more than 5 half-lives of the prior study drug, whichever is shorter.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Sichuan University

OTHER

Sponsor Role: lead

Responsible Party

Yongsheng Wang

Vice-Director of Cancer Center of West China Hospital

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Yongsheng Wang, Prof

Role: PRINCIPAL_INVESTIGATOR

West China Hospital

Locations

West China Hospital, Sichuan University

Chengdu, Sichuan, China

Site Status: RECRUITING

Countries

China

Central Contacts

Ge Gao, PhD

Role: CONTACT

gg1023@foxmail.com

86（028）85421606

Facility Contacts

Ge Gao, PhD

Role: primary

gg1023@foxmail.com

86（028）85421606

Other Identifiers

HX-AK112-02

Identifier Type: -

Identifier Source: org_study_id