Evaluation of Chronic Liver Disease Condition and Transplant Prognosis Assisted by Eye Biological Parameters
NCT ID: NCT06756009
Last Updated: 2025-01-01
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
500 participants
OBSERVATIONAL
2022-03-01
2026-12-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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preoperative group
Registered liver transplant patients from preoperative to postoperative follow-up
Ophthalmic examination
Various ophthalmic examination modalities, including slit lamp photography, fundus photography, optical coherence tomography imaging and optical coherence tomography angiography, etc.
General Condition Examination
Various general condition examination, including blood pressure measurement, blood glucose testing, blood routine examination, coagulation function test, liver function test, etc.
Simple postoperative group
Follow up from after liver transplantation
Ophthalmic examination
Various ophthalmic examination modalities, including slit lamp photography, fundus photography, optical coherence tomography imaging and optical coherence tomography angiography, etc.
General Condition Examination
Various general condition examination, including blood pressure measurement, blood glucose testing, blood routine examination, coagulation function test, liver function test, etc.
Healthy control group
Healthy individuals without liver disease
Ophthalmic examination
Various ophthalmic examination modalities, including slit lamp photography, fundus photography, optical coherence tomography imaging and optical coherence tomography angiography, etc.
General Condition Examination
Various general condition examination, including blood pressure measurement, blood glucose testing, blood routine examination, coagulation function test, liver function test, etc.
Interventions
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Ophthalmic examination
Various ophthalmic examination modalities, including slit lamp photography, fundus photography, optical coherence tomography imaging and optical coherence tomography angiography, etc.
General Condition Examination
Various general condition examination, including blood pressure measurement, blood glucose testing, blood routine examination, coagulation function test, liver function test, etc.
Eligibility Criteria
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Inclusion Criteria
2. Late stage liver disease patients waiting for liver transplantation treatment, as well as patients with varying degrees of cirrhosis;
3. Can collect complete basic demographic information, liver function blood test indicators, liver pathology and imaging examination results;
4. Can cooperate with eye OCT, OCTA and other examinations, and obtain qualified examination parameters;
5. Voluntarily follow the clinical trial protocol and sign the informed consent form.
Exclusion Criteria
2. History of intraocular laser treatment, medication injection, and surgery;
3. History of high myopia, glaucoma, and retinal choroidal related eye diseases;
4. History of major systemic diseases other than liver disease;
5. Individuals whose overall body and eye conditions cannot cooperate with eye examinations.
18 Years
ALL
Yes
Sponsors
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First Affiliated Hospital, Sun Yat-Sen University
OTHER
Second Affiliated Hospital, Sun Yat-Sen University
OTHER
Guangdong Provincial People's Hospital
OTHER
Nanfang Hospital of Southern Medical University, Guangdong of China
UNKNOWN
Zhongshan People's Hospital, Guangdong, China
OTHER
Guangdong Provincial People's Hospital, China
UNKNOWN
First People's Hospital of Foshan
OTHER
Zhongshan Ophthalmic Center, Sun Yat-sen University
OTHER
Responsible Party
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Haotian Lin
Prof.
Locations
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Zhongshan Ophthalmic Center, Sun Yat-sen University
Guangzhou, Guangdong, China
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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2021KYPJ148
Identifier Type: -
Identifier Source: org_study_id
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