Investigating Novel Strategies in Pediatric Immune Responses and Microbiome Environment: Comprehensive Lung Disease Investigation in Children.

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ENROLLING_BY_INVITATION

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-04-30

Study Completion Date

2027-12-31

Brief Summary

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The INSPIRE CHILD-study is a clinical research project focused on understanding lung diseases in children. The study aims to explore how the presence of certain bacteria, immune responses, and inflammatory markers in the lungs are connected to different lung diseases in pediatric patients.

Background:

Lung diseases in children can have long-lasting effects on their health, not only during childhood but also as they grow into adults. However, the specific causes and mechanisms behind these diseases are not yet fully understood. The INSPIRE CHILD-study is designed to investigate whether children with various lung conditions have distinct differences in the types of bacteria, immune system activity, and inflammation in their lungs.

Hypothesis:

Different lung diseases in children are hypothesized to be associated with unique patterns of bacteria, immune responses, and inflammation in the lungs By studying these patterns, the investigators hope to gain new insights that could lead to better diagnostic tools and more personalized treatments for children suffering from lung diseases.

Children already scheduled to undergo bronchoscopy are included in the study. A small sample of fluid from the lungs is collected, and the sample is analyzed for bacteria, immune markers, and signs of inflammation. This research could pave the way for improved care and treatment for young patients with lung conditions.

Detailed Description

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Conditions

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Lung Diseases

Keywords

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Pediatric Lung Disease Microbiome Cytokine Inflammation Immune Cell Bacteria Asthma Coughing Immunophenotype Bronchiectasis Bronchoscopy BAL Bronchoalveolar lavage Diffuse Lung Disease Interstitial Lung Disease

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Interventions

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No intervention

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Age ranging from new-born to 17 years of age.
* Diagnosed with or being assessed for a lung disease.
* Possible to sample at least 2 ml of BAL-fluid besides the scheduled amount during the bronchoscopy.

Exclusion Criteria

* Age older than 17 years.
* Not undergoing diagnosis at Childrens Center for Pulmonary and Allergic diseases.
* Failure to meet the requirement of being able to sample an additional 2 ml of BAL-fluid.

Minimum Eligible Age

0 Years

Maximum Eligible Age

17 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Responsible Party

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Sune Rubak

Consultant, Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Childrens Center for Pulmonary and Allergic diseases, Aarhus University Hospital

Aarhus N, , Denmark

Site Status

Countries

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Denmark

Other Identifiers

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VEK j.nr. 1-10-72-8-24

Identifier Type: -

Identifier Source: org_study_id