BSD-10CH TDCS for Upper Limb Function Improvement in Stroke Patients: a Randomized Clinical Trial

NCT ID: NCT06740604

Last Updated: 2024-12-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-02-21

Study Completion Date

2025-12-31

Brief Summary

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This clinical study compares the effectiveness and safety of the BSD-10CH transcranial direct current stimulation (tDCS) device, applied alongside rehabilitation therapy, with a control device in stroke patients. After 4 weeks of treatment, the study evaluates the transient improvement in motor cortex activation and upper extremity function between the two groups.

Detailed Description

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Conditions

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Stroke TDCS

Keywords

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Stroke tDCS

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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BSD-10CH

The BSD-10CH stimulation was applied five times a week for 4 weeks, with each session lasting 20 minutes per day.

Group Type EXPERIMENTAL

BSD-10CH

Intervention Type DEVICE

The BSD-10CH stimulation was applied five times a week for 4 weeks, with each session lasting 20 minutes per day.

Sham BSD-10CH

The Sham BSD-10CH stimulation was applied five times a week for 4 weeks, with each session lasting 20 minutes per day.

Group Type SHAM_COMPARATOR

Sham BSD-10CH

Intervention Type DEVICE

The Sham BSD-10CH stimulation was applied five times a week for 4 weeks, with each session lasting 20 minutes per day.

Interventions

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BSD-10CH

The BSD-10CH stimulation was applied five times a week for 4 weeks, with each session lasting 20 minutes per day.

Intervention Type DEVICE

Sham BSD-10CH

The Sham BSD-10CH stimulation was applied five times a week for 4 weeks, with each session lasting 20 minutes per day.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Adults aged 19 years or older.
* Diagnosed with stroke based on clinical observation and neuroimaging.
* First-time stroke patients (1st stroke).
* Stroke onset between 2 weeks and 12 months prior to screening.
* Stroke lesion located in the cortex or subcortex.
* Presence of hemiparesis in the upper limb.
* Upper limb FMA score of 53 or lower.
* Ability to read and understand the informed consent form, and to respond to questionnaires.
* Willing to voluntarily participate in the clinical trial, and able to provide written informed consent to participate throughout the study period.

Exclusion Criteria

* Recurrent stroke, traumatic brain injury, spinal cord injury, degenerative neurological diseases (such as Parkinson's disease), or other conditions affecting upper limb function.
* MMSE score of 19 or lower, indicating dementia, and inability to follow study instructions.
* Global aphasia or communication disorders.
* Brain injury caused by trauma, ischemia, hypoxia, or similar conditions.
* Uncontrolled medical or surgical conditions.
* Skin inflammation or other dermatological issues that may prevent attachment of tDCS electrodes.
* Medical contraindications for the use of tDCS devices (e.g., pacemaker, aneurysm clips, prosthetic heart valves, cochlear implants, or other implanted metal devices).
* Previous use of similar stimulation devices or participation in related clinical trials within the last year.
* History of major psychiatric disorders (e.g., major depressive disorder, schizophrenia, bipolar disorder, or dementia) within the past 5 years.
* History of epilepsy (seizures) within the past 5 years.
* History of substance abuse (e.g., neuroleptics, sedatives, narcotics, or illicit drugs) within the past 5 years.
* Participants requiring changes in medications that could affect cognitive or motor function during the study (unless the participant has been on stable, prohibited medications for at least 3 months).
* History of alcohol addiction treatment within the last 5 years.
* Severe visual impairment that cannot be corrected with glasses, preventing the reading of standard print.
* Hearing impairment that prevents communication, even with hearing aids.
* Difficulty breathing at rest.
* A history of suicide attempts within the past 6 months.
* Pregnant or breastfeeding women, or men and women of reproductive age who do not agree to use appropriate contraception throughout the study. \*Acceptable methods of contraception include:

* Hormonal methods (oral contraceptives, injections, patches, implants, etc.)
* Surgical sterilization (vasectomy, bilateral tubal ligation)
* Dual protection (male condoms, diaphragm, cervical cap)
* Intrauterine devices or systems.
* Pregnant or breastfeeding participants.
* Any other clinical condition deemed by the investigator to make the participant unsuitable for the study.
Minimum Eligible Age

19 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Pusan National University Yangsan Hospital

OTHER

Sponsor Role lead

Responsible Party

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Yong-il Shin

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Young-Il Shin, Dr.

Role: STUDY_DIRECTOR

Pusan National University Yangsan Hospital

Locations

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Pusan national university Yangsan Hospital

Gyeongsang, Yangsan, South Korea

Site Status

Countries

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South Korea

Other Identifiers

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23-2024-004

Identifier Type: -

Identifier Source: org_study_id