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Genetic Determinants of Exercise-Induced Muscle Damage (POLYGENDOMUS)

NCT ID: NCT06740136

Last Updated: 2024-12-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

300 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-03-13

Study Completion Date

2025-12-19

Brief Summary

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The objective of this study is to evaluate the association between the evolution of plasma CPK levels and genetic polymorphisms, both before the muscle-damaging exercise and at three post-exercise time points. The investigators aim to include 300 participants in this research.

Detailed Description

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Elite-level sports expose athletes to training loads designed to induce muscle damage, aiming to achieve optimal physiological adaptations. However, the repetitive nature of such damage increases the risk of injury. The ability to assess an athlete's susceptibility to fragility is therefore crucial for optimizing their training and performance. Genetic factors appear to play a significant role in the occurrence of these injuries, particularly through subtle variations in DNA sequences. Depending on the location of these variations within a gene, they may or may not alter the expression or function of the associated protein. The investigators aimed to investigate the relationship between genetic polymorphisms and biological parameters in the context of exercise-induced muscle damage.

Conditions

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Healthy

Keywords

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Muscle damage Single nucleotide polymorphism exercise

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Intervention model
Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Exercise

exercise group

Group Type EXPERIMENTAL

Exercise

Intervention Type OTHER

Muscle induced-damage eccentric exercise

Interventions

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Exercise

Muscle induced-damage eccentric exercise

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Male or female
* Aged between 18 and 35
* Weighing more than 50 kg
* Member of a sports club affiliated to an Olympic federation
* Socially insured
* Willing to comply with all study procedures and duration of the study

Exclusion Criteria

* Medical history contraindicating sporting activities
* Current medical treatment
* Not a member of a sports club affiliated to an Olympic federation
* Administrative reasons: impossibility of receiving informed information, impossibility of participating in the entire study, absence of social security coverage, refusal to sign consent form.
Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Lille University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Eurasport

Loos, , France

Site Status RECRUITING

Countries

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France

Facility Contacts

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Frédéric DAUSSIN, PhD

Role: primary

Related Links

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https://urepsss.univ-lille.fr/

Related Info

Other Identifiers

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2022-A01308-35

Identifier Type: OTHER

Identifier Source: secondary_id

2022-007

Identifier Type: -

Identifier Source: org_study_id