RCT of Efficacy and Safety of CP003 on CFS/ME or Post-COVID Fatigue

NCT ID: NCT06739720

Last Updated: 2024-12-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

PHASE2/PHASE3

Total Enrollment

130 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-01-02

Study Completion Date

2026-12-31

Brief Summary

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The goal of this clinical trial is to test if a Lingzhi supplement (CP003) helps people with chronic fatigue or post-COVID fatigue feel better. It will also check if the supplement is safe to use. The main questions it aims to answer are:

Does the Lingzhi supplement reduce fatigue symptoms? Is it safe to take? How does it affect the body's immune system and inflammation?

Researchers will compare people taking the Lingzhi supplement to those who don't take anything (waitlist group) to see if it works.

Participants will:

* Take 5 capsules once daily for 6 weeks (or wait to start treatment if in waitlist group)
* Visit the clinic 2 times for blood tests (before and after taking the supplement)
* Complete questionnaires 3 times about their fatigue and quality of life (4 times questionnaires for waitlist group)

Detailed Description

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Conditions

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Chronic Fatigue Syndrome (CFS) Post-COVID ME/CFS

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Participants are randomly assigned in a 1:1 ratio to either the intervention group or the waitlist group. The intervention group receives CP003 capsules (5 capsules once daily) for 6 weeks. The waitlist group undergoes a 6-week waiting period without any treatment.
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Intervention group

Participants receive CP003 capsules (5 capsules once daily) for 6 weeks, followed by a 6-week follow-up period.

Group Type EXPERIMENTAL

LingZhi capsule

Intervention Type DRUG

Lingzhi-containg capsules (CP003) is a Chinese Medicine nutritional supplement manufactured by Chinese Pharm CO LTD containing: wild red ganoderma extract, ganoderma spore powder (99.9% broken wall), β-nicotinamide mononucleotide (NMN), wild yellow ganoderma extract, wild green ganoderma extract, wild purple ganoderma extract, wild white ganoderma extract, wild black sesame extract

Waitlist group

Participants initially wait for 6 weeks after randomization without intervention. After the waiting period, they receive the same CP003 supplement regimen (5 capsules once daily) for 6 weeks, followed by a 6-week follow-up period.

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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LingZhi capsule

Lingzhi-containg capsules (CP003) is a Chinese Medicine nutritional supplement manufactured by Chinese Pharm CO LTD containing: wild red ganoderma extract, ganoderma spore powder (99.9% broken wall), β-nicotinamide mononucleotide (NMN), wild yellow ganoderma extract, wild green ganoderma extract, wild purple ganoderma extract, wild white ganoderma extract, wild black sesame extract

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Meet the Fukuda diagnostic definition of CFS/ME or have persisting fatigue after the infection of SARS-CoV-2
* Are able to complete a 6-week course of intervention;
* Able to complete the online validated fatigue surveys.

Exclusion Criteria

* Have participated in any type of complements or herbal medicine within the past six months;
* Have serious medical conditions that might limit their participation in this intervention;
* Diagnosed with acute inflammation;
* Are pregnant or are planning a pregnancy in the next 3 months.
Minimum Eligible Age

40 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Innovation and Technology Commission, Hong Kong

OTHER

Sponsor Role collaborator

The University of Hong Kong

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Specialist Clinical Centre for Teaching and Research, School of Chinese Medicine, The University of Hong Kong

Hong Kong, , Hong Kong

Site Status

Countries

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Hong Kong

Central Contacts

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TUNG LEONG FONG

Role: CONTACT

Phone: +852 5660 4020

Email: [email protected]

Guang Chen

Role: CONTACT

Phone: +852 3917 6515

Email: [email protected]

Facility Contacts

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TUNG LEONG FONG

Role: primary

Other Identifiers

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HKWC-2024-320

Identifier Type: -

Identifier Source: org_study_id