French COhoRte Extra-Vascular Implantable CardiovErter DefibrillatoR

NCT ID: NCT06739239

Last Updated: 2024-12-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

1000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-02-01

Study Completion Date

2030-12-31

Brief Summary

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Implantable cardioverter-defibrillators (ICDs) are widely recognized for their efficacy in reducing the risk of sudden cardiac death in high-risk patients. Nonetheless, there remains significant scope for improving outcomes through advancements in device technology and design. The extravascular cardioverter-defibrillator (EV-ICD) represents such an innovation, offering key advantages over other ICD systems. It incorporates a lead positioned in the substernal space, enabling the delivery of pause-prevention security pacing, antitachycardia pacing, and defibrillation energy similar to that provided by conventional transvenous ICDs.

Previous studies have demonstrated that EV-ICDs can be implanted safely and are capable of terminating majority of induced ventricular arrhythmias during implantation; however, follow-up data are limited to highly experienced selected centers and over a relatively small follow-up period (6-month follow-up). The FOREVER cohort study, initiated by the French Institute of Health and Medical Research, aims to evaluate the EV-ICD use in France.

This nationwide evaluation will provide an exhaustive collection of all EV-ICD implantations in France, offering valuable real-world evidence on the long-term safety and efficacy of the device.

Detailed Description

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Conditions

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Defibrillators, Implantable Sudden Cardiac Death Due to Cardiac Arrhythmia

Keywords

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Implantable cardioverter defibrillator sudden cardiac death Extravascular Implantable Cardioverter-Defibrillator

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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All patients implanted with EV-ICD in France

Extra-Vascular Implantable Cardioverter Defibrillator

Intervention Type DEVICE

The pulse generator is implanted along the patient's left midaxillary line, and the lead is positioned substernally.

Interventions

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Extra-Vascular Implantable Cardioverter Defibrillator

The pulse generator is implanted along the patient's left midaxillary line, and the lead is positioned substernally.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* All patients undergoing EV-ICD implantation

Exclusion Criteria

* Refusal of consent
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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European Georges Pompidou Hospital

OTHER

Sponsor Role collaborator

University Hospital, Grenoble

OTHER

Sponsor Role collaborator

University Hospital, Clermont-Ferrand

OTHER

Sponsor Role collaborator

University Hospital, Rouen

OTHER

Sponsor Role collaborator

Centre Hospitalier Universitaire de Besancon

OTHER

Sponsor Role collaborator

Clinique du Millenaire

OTHER

Sponsor Role collaborator

Institut Mutualiste Montsouris

OTHER

Sponsor Role collaborator

Groupe Hospitalier Pitie-Salpetriere

OTHER

Sponsor Role collaborator

University Hospital, Lille

OTHER

Sponsor Role collaborator

University Hospital, Caen

OTHER

Sponsor Role collaborator

Hospices Civils de Lyon

OTHER

Sponsor Role collaborator

CHU de la Timone, Marseille, France

UNKNOWN

Sponsor Role collaborator

Centre Cardio-Thoracique de Monaco

UNKNOWN

Sponsor Role collaborator

Hospital of Lens

UNKNOWN

Sponsor Role collaborator

Institute Arnault Tzanck, France

OTHER

Sponsor Role collaborator

University Hospital, Strasbourg, France

OTHER

Sponsor Role collaborator

University Hospital, Limoges

OTHER

Sponsor Role collaborator

University Hospital, Montpellier

OTHER

Sponsor Role collaborator

Clinique Pasteur Toulouse

OTHER

Sponsor Role collaborator

University Hospital, Bordeaux

OTHER

Sponsor Role collaborator

University Hospital, Toulouse

OTHER

Sponsor Role collaborator

Institut Jacques Cartier - Massy

UNKNOWN

Sponsor Role collaborator

Clinique Saint Augustin - Bordeaux

UNKNOWN

Sponsor Role collaborator

Rennes University Hospital

OTHER

Sponsor Role collaborator

Clinique de la Sauvegarde

OTHER

Sponsor Role collaborator

University Hospital of Saint-Etienne

OTHER

Sponsor Role collaborator

Centre Hospitalier Universitaire, Amiens

OTHER

Sponsor Role collaborator

Poitiers University Hospital

OTHER

Sponsor Role collaborator

Clinique Saint-Gatien - Tours

UNKNOWN

Sponsor Role collaborator

CHU de Reims

OTHER

Sponsor Role collaborator

Centre Hospitalier Universitaire Dijon

OTHER

Sponsor Role collaborator

Hospital St. Joseph, Marseille, France

OTHER

Sponsor Role collaborator

Centre Hospitalier Annecy Genevois

OTHER

Sponsor Role collaborator

Clinique St Pierre, Perpignan, France

UNKNOWN

Sponsor Role collaborator

Bichat Hospital

OTHER

Sponsor Role collaborator

Universite de La Reunion

OTHER

Sponsor Role collaborator

University Hospital Center of Martinique

OTHER

Sponsor Role collaborator

Henri Mondor University Hospital

OTHER

Sponsor Role collaborator

University Hospital, Angers

OTHER_GOV

Sponsor Role collaborator

Central Hospital, Nancy, France

OTHER

Sponsor Role collaborator

Hôpital privé Clairval - Marseille

UNKNOWN

Sponsor Role collaborator

Médipôle Lyon-Villeurbanne

OTHER

Sponsor Role collaborator

Hôpital Privé Les Franciscaines

OTHER

Sponsor Role collaborator

Hospital Ambroise Paré Paris

OTHER

Sponsor Role collaborator

Central Hospital, Metz Thionville, France

UNKNOWN

Sponsor Role collaborator

Hopital Prive Saint Martin - Bordeaux

UNKNOWN

Sponsor Role collaborator

Hôpital Privé de Parly II - Le Chesnay

OTHER

Sponsor Role collaborator

Paris Sudden Death Expertise Center

OTHER

Sponsor Role lead

Responsible Party

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Marijon

Head of Cardiology Division

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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European Georges Pompidou Hospital

Paris, , France

Site Status RECRUITING

Countries

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France

Central Contacts

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Eloi MARIJON, MD, PhD

Role: CONTACT

Phone: 662833848

Email: [email protected]

Fawzi KERKOURI, MD, MPH

Role: CONTACT

Phone: 7 67 14 95 58‬

Email: [email protected]

Facility Contacts

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Eloi Marijon, Head of Cardiology Department

Role: primary

Other Identifiers

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2236443v0

Identifier Type: -

Identifier Source: org_study_id