Medical Nutrition Formulations Enriched With Postbiotics for the Management of Gastrointestinal Disorders

NCT ID: NCT06738420

Last Updated: 2025-10-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-01-27

Study Completion Date

2024-04-04

Brief Summary

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Efficacy and tolerability of ABB i5 prebiotic and ABB C22 postbiotics for the management of constipation and gastrointestinal well-being: a pilot trial

Detailed Description

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Conditions

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Diarrhoea of Diverse Aetiology Requiring Oral Rehydration Therapy Diarrhoea and Gastrointestinal Symptoms Secondary to Enteral Nutrition

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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ABB S3 - active

Postbiotic ABB S3 for suspension into Nutritional supplementation with Medical Nutrition Formula for the management of gastrointestinal symptoms secondary to enteral nutrition

Group Type EXPERIMENTAL

ABB S3

Intervention Type DIETARY_SUPPLEMENT

Postbiotic ABB S3 for suspension into Nutritional supplementation with Medical Nutrition Formula for the management of gastrointestinal symptoms secondary to enteral nutrition

ABB S3 - Placebo

Placebo for suspension into Nutritional supplementation with Medical Nutrition Formula for the management of gastrointestinal symptoms secondary to enteral nutrition

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DIETARY_SUPPLEMENT

Placebo for suspension into Nutritional supplementation with Medical Nutrition Formula for the management of gastrointestinal symptoms secondary to enteral nutrition

ABB C22 - active

Oral Rehydration Solution containing postbiotics ABB C22 for the management of diarrhoea signs of dehydration

Group Type EXPERIMENTAL

ABB C22

Intervention Type DIETARY_SUPPLEMENT

Oral Rehydration Solution containing postbiotics ABB C22 for the management of diarrhoea signs of dehydration

ABB C22 - placebo

Oral Rehydration Solution containing placebo for the management of diarrhoea signs of dehydration

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DIETARY_SUPPLEMENT

Oral Rehydration Solution containing placebo for the management of diarrhoea signs of dehydration

Interventions

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ABB S3

Postbiotic ABB S3 for suspension into Nutritional supplementation with Medical Nutrition Formula for the management of gastrointestinal symptoms secondary to enteral nutrition

Intervention Type DIETARY_SUPPLEMENT

ABB C22

Oral Rehydration Solution containing postbiotics ABB C22 for the management of diarrhoea signs of dehydration

Intervention Type DIETARY_SUPPLEMENT

Placebo

Placebo for suspension into Nutritional supplementation with Medical Nutrition Formula for the management of gastrointestinal symptoms secondary to enteral nutrition

Intervention Type DIETARY_SUPPLEMENT

Placebo

Oral Rehydration Solution containing placebo for the management of diarrhoea signs of dehydration

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Inpatients of the centre

* Diagnostic of diarrhoea: increase in daily faecal weight \> 200 g (as per the Centre protocol).
* Subjects who as per the Centre protocol require Oral rehydration therapy
* Patients with the ability to take the study product orally

Exclusion Criteria

* History of allergy, idiosyncrasy, hypersensitivity or adverse reactions to the active principle or to any of the excipients.

* History or evidence of any medical conditions or medication used that, in the opinion of the principal investigator, could affect the safety of the subjects or interfere with the study evaluations
* Patients in situation of last days
* Amytriptilin and masalazine treatment (anti-depressives)
* Laxatives
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Colisée Barcelona Isabel Roig

UNKNOWN

Sponsor Role collaborator

Grupo Colisée

UNKNOWN

Sponsor Role collaborator

AB Biotek

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Isabel Roig

Barcelona, Barcelona, Spain

Site Status

Countries

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Spain

References

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Mateus Rodriguez JA, Rodriguez Sanz P, Kostandyan E, Palacios Sanchez R, Pino Roque ML, Chaves Vasquez P, Roy Millan P. Mitigating Diarrhoea-Related Inflammation in Frail Older Adults with Postbiotic-Enhanced Oral Rehydration Solution: Insights from a Randomised, Double-Blind, Placebo-Controlled Study. Geriatrics (Basel). 2025 Mar 1;10(2):34. doi: 10.3390/geriatrics10020034.

Reference Type DERIVED
PMID: 40126284 (View on PubMed)

Other Identifiers

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2022-003423-18

Identifier Type: -

Identifier Source: org_study_id

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