A Phase III Study of SHR-A2102 Versus Investigator-selected Therapy in Advanced Urothelial Carcinoma

NCT ID: NCT06738251

Last Updated: 2025-07-17

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: PHASE3
• Total Enrollment: 402 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2025-02-12
• Study Completion Date: 2027-09-30

Brief Summary

To evaluate the efficacy and safety of SHR-A2102 for injection versus Investigator-selected Therapy in patients with Locally advanced or Metastatic Urothelial Carcinoma who have been previously treated with platinum-based chemotherapy and PD-(L)1 inhibitors.

Conditions

Advanced Urothelial Carcinoma

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

SHR-A2102 group

Group Type: EXPERIMENTAL

SHR-A2102 for Injection

Intervention Type: DRUG

SHR-A2102 for Injection.

Investigator-selected therapy group

Group Type: ACTIVE_COMPARATOR

Docetaxel Injection

Intervention Type: DRUG

Docetaxel Injection.

Paclitaxel Injection

Intervention Type: DRUG

Paclitaxel Injection.

Gemcitabine Hydrochloride for Injection

Intervention Type: DRUG

Gemcitabine Hydrochloride for Injection.

Pemetrexed Disodium for Injection

Intervention Type: DRUG

Pemetrexed Disodium for Injection.

Interventions

SHR-A2102 for Injection

SHR-A2102 for Injection.

Intervention Type: DRUG

Docetaxel Injection

Docetaxel Injection.

Intervention Type: DRUG

Paclitaxel Injection

Paclitaxel Injection.

Intervention Type: DRUG

Gemcitabine Hydrochloride for Injection

Gemcitabine Hydrochloride for Injection.

Intervention Type: DRUG

Pemetrexed Disodium for Injection

Pemetrexed Disodium for Injection.

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

1. Voluntarily participate in this clinical study, understand the study procedures and be able to sign the informed consent form in writing.

2. 18 to 80 years old (including boundary value), gender is not limited.

3. ECOG performance status score of 0 or 1.

4. Estimated survival ≥ 3 months.

5. Pathologically confirmed urothelial carcinoma confirmed by imaging or other methods as locally advanced unresectable or metastatic disease.

6. Patients with locally advanced or metastatic disease who have previously received both a platinum-based chemotherapy regimen and a PD-(L)1 inhibitor; patients who received platinum-based chemotherapy and/or a PD-(L)1 inhibitor as neoadjuvant or adjuvant therapy and experienced recurrence or progression during treatment or within 6 months after completing treatment will be considered to have received these therapies in the locally advanced/metastatic setting.

7. Imaging-confirmed disease progression during or after treatment with the most recent regimen.

8. Able to provide preserved or fresh tumor tissue.

9. Must be present with at least one measurable lesion according to RECIST v1.1 criteria.

10. Good level of organ function.

11. Male subjects whose partners are women of childbearing potential and female subjects of childbearing potential must use highly effective contraception from the time of signing the informed consent form until 8 months after the last dose of the trial drug.

Exclusion Criteria

1. Planned to receive any other anti-tumor therapy during this trial.

2. Receipt of other unmarketed clinical trial drugs or treatments within 4 weeks prior to randomization.

3. Received systemic anti-tumor therapy such as chemotherapy, radiotherapy, biological therapy, targeted therapy, or immunotherapy within 4 weeks prior to randomization, and palliative radiotherapy or local therapy within 2 weeks prior to the first use of the investigational drug.

4. Prior receipt of antibody-drug conjugates containing topoisomerase I inhibitors in the composition.

5. For locally advanced or metastatic disease: patients who have previously received more than three lines of systemic therapy in this setting.For neoadjuvant or adjuvant therapy: if the disease recurs or progresses during treatment or within 6 months after its completion, the patient is considered to have received first-line systemic therapy for locally advanced or metastatic disease.

6. Prior treatment with more than 1 antibody-drug conjugate.

7. Major surgery other than diagnosis or biopsy within 4 weeks prior to randomization that requires elective surgery during the trial.

8. Received systemic glucocorticoids (prednisone > 10 mg/day or equivalent dose) or other immunosuppressants within 14 days prior to the first use of investigational drug or randomization for immunosuppressive purposes.

9. Adverse events from prior antineoplastic therapy did not recover to Grade ≤1 according to NCI-CTCAE v5.0.

10. Inadequately treated central nervous system (CNS) metastases, or the presence of uncontrolled or symptomatic active central nervous system metastases. CNS metastases that have been adequately treated and whose neurological symptoms are able to return to baseline at least 4 weeks prior to randomization (with the exception of residual signs or symptoms associated with CNS treatment) may be enrolled in the study.

11. Subject has a serous effusion with clinical symptoms or requiring puncture and drainage.

12. Any malignancy diagnosed within 5 years prior to randomization (calculated from the date of the last anti-tumor treatment), except:Localized, low-risk prostate cancer.Papillary thyroid carcinoma, basal-cell carcinoma, or squamous-cell carcinoma of the skin that has been adequately treated and shows no evidence of disease.Other carcinomas in situ that have been adequately treated and show no evidence of disease recurrence.

13. History of interstitial pneumonitis/interstitial lung disease or non-infectious pneumonitis (e.g., radiation pneumonitis) that required systemic corticosteroid therapy.Current evidence, in the investigator's judgment, of uncontrolled interstitial pneumonitis/interstitial lung disease, non-infectious pneumonitis, or any other active pneumonitis.

14. Severe infections requiring intravenous antibiotics, antivirals, or antifungals for control.

15. Active hepatitis B virus (HBV) or hepatitis C virus (HCV) infection.

16. Has a history of immunodeficiency or organ transplantation.

17. Any serious arterial or venous thrombotic event within 6 months before randomization.

18. Those who have had significant clinically significant bleeding symptoms within 3 months before the first study drug.

19. Glycosylated hemoglobin (HbA1c) ≥8%.

20. Have severe cardiovascular and cerebrovascular diseases.

21. Allergic reaction to any component of this study treatment.

22. Female subjects who are pregnant or plan to become pregnant during the study.

23. According to the judgment of the investigator, there are concomitant diseases (such as thyroid disease and mental illness, etc.) or any other conditions that seriously endanger the safety of the patient, or affect the patient's completion of this study.

24. Prior treatment for urothelial carcinoma with all chemotherapy agents included in the control-arm regimen.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Shanghai Hengrui Pharmaceutical Co., Ltd.

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Beijing Cancer Hospital

Beijing, Beijing Municipality, China

Site Status: RECRUITING

Countries

China

Central Contacts

Chi Zhang, M.M

Role: CONTACT

chi.zhang@hengrui.com

+86-18456513908

Zhaoxiang Wang, M.M

Role: CONTACT

zhaoxiang.wang.zw170@hengrui.com

+86-19181783204

Facility Contacts

Jun Guo

Role: primary

guoj307@126.com

010-88121122

Other Identifiers

SHR-A2102-301

Identifier Type: -

Identifier Source: org_study_id