Increasing Oral Medication Adherence for Metastatic Breast Cancer Patients

NCT ID: NCT06726889

Last Updated: 2024-12-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

104 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-01-25

Study Completion Date

2025-04-30

Brief Summary

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Aim of this study is to optimize an adherence increasing intervention designed for metastatic Breast Cancer (BC) patients by applying a full factorial design in order to evaluate the optimal combination of three different intervention components.

Detailed Description

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Today different types of Oral Anticancer Agents (OAA) are commonly prescribed to Breast Cancer (BC) patients. Patients are reported to prefer the oral modality of administration over the intravenous one for its convenience, flexibility, and easier assumption; nonetheless, the phenomenon of medication non-adherence is well-documented.

Although several interventions have been designed and tested in order to foster medication adherence among BC patients, the great majority of them were focused on adherence to endocrine therapy for early-stage BC patients, with only few exceptions involving metastatic BC patients or considering adherence to other types of OAA.

The aim of this work is to optimize an adherence increasing intervention designed for metastatic BC patients. This will be achieved by applying a full factorial design in order to evaluate the optimal combination of three different intervention components (informative documentation, personalized reminders and feedback).

Conditions

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Breast Cancer

Keywords

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Metastatic Breast Cancer Oral Anticancer Agents Oral Medication Adherence

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Standard Care + DSS + Reminders + Feedback

Patients will receive educational material through a web-page, personalized reminders and feedback messages by physician

Standard care

Intervention Type BEHAVIORAL

Patient will not receive any additional interventions

Decision Support System (DSS)

Intervention Type BEHAVIORAL

DSS will be used to deliver educational material through a web-page (in Italian language) accessible through a link

Reminders

Intervention Type BEHAVIORAL

Personalized reminders will be delivered to patients through a common messaging application (WhatsApp)

Feedback

Intervention Type BEHAVIORAL

Feedback message will be delivered by physician to patients, through WhatsApp, after medication diary revision

Standard Care + DSS + Reminders

Patients will receive educational material through a web-page and personalized reminders

Standard care

Intervention Type BEHAVIORAL

Patient will not receive any additional interventions

Decision Support System (DSS)

Intervention Type BEHAVIORAL

DSS will be used to deliver educational material through a web-page (in Italian language) accessible through a link

Reminders

Intervention Type BEHAVIORAL

Personalized reminders will be delivered to patients through a common messaging application (WhatsApp)

Standard Care + DSS + Feedback

Patients will receive educational material through a web-page and feedback messages by physician

Standard care

Intervention Type BEHAVIORAL

Patient will not receive any additional interventions

Decision Support System (DSS)

Intervention Type BEHAVIORAL

DSS will be used to deliver educational material through a web-page (in Italian language) accessible through a link

Feedback

Intervention Type BEHAVIORAL

Feedback message will be delivered by physician to patients, through WhatsApp, after medication diary revision

Standard Care + DSS

Patients will receive educational material through a web-page

Standard care

Intervention Type BEHAVIORAL

Patient will not receive any additional interventions

Decision Support System (DSS)

Intervention Type BEHAVIORAL

DSS will be used to deliver educational material through a web-page (in Italian language) accessible through a link

Standard Care + Reminders + Feedback

Patients will receive personalized reminders and feedback messages by physician

Standard care

Intervention Type BEHAVIORAL

Patient will not receive any additional interventions

Reminders

Intervention Type BEHAVIORAL

Personalized reminders will be delivered to patients through a common messaging application (WhatsApp)

Feedback

Intervention Type BEHAVIORAL

Feedback message will be delivered by physician to patients, through WhatsApp, after medication diary revision

Standard Care + Reminders

Patients will receive personalized reminders

Standard care

Intervention Type BEHAVIORAL

Patient will not receive any additional interventions

Reminders

Intervention Type BEHAVIORAL

Personalized reminders will be delivered to patients through a common messaging application (WhatsApp)

Standard Care + Feedback

Patients will receive feedback messages by physician

Standard care

Intervention Type BEHAVIORAL

Patient will not receive any additional interventions

Feedback

Intervention Type BEHAVIORAL

Feedback message will be delivered by physician to patients, through WhatsApp, after medication diary revision

Standard Care

Patient will not receive any additional interventions

Standard care

Intervention Type BEHAVIORAL

Patient will not receive any additional interventions

Interventions

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Standard care

Patient will not receive any additional interventions

Intervention Type BEHAVIORAL

Decision Support System (DSS)

DSS will be used to deliver educational material through a web-page (in Italian language) accessible through a link

Intervention Type BEHAVIORAL

Reminders

Personalized reminders will be delivered to patients through a common messaging application (WhatsApp)

Intervention Type BEHAVIORAL

Feedback

Feedback message will be delivered by physician to patients, through WhatsApp, after medication diary revision

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Patients with a diagnosis of metastatic BC
* Patients with a prescription for any OAA (i.e. oral chemotherapy, endocrine therapy, and Cyclin-Dependent Kinase 4/6 Inhibitors)
* Age \>18 years old
* Patients with a personal smart phone with internet access
* Willingness and ability to comply with scheduled visits and other trial procedures
* Understanding and speaking Italian language
* Written informed consent

Exclusion Criteria

* Psychiatric disorders or conditions that might impair the ability to give informed consent
* Comorbidity that may impact on compliance to study procedures
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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European Institute of Oncology

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Gabriella Pravettoni, MD

Role: PRINCIPAL_INVESTIGATOR

European Istitute of Oncology

Locations

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European Institute of Oncology

Milan, , Italy

Site Status RECRUITING

Countries

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Italy

Central Contacts

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Gabriella Pravettoni, MD

Role: CONTACT

Phone: +39 0257489731

Email: [email protected]

Mara Negri

Role: CONTACT

Phone: +39 0257489536

Email: [email protected]

Facility Contacts

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Gabriella Pravettoni, MD

Role: primary

Other Identifiers

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IEO 2014

Identifier Type: -

Identifier Source: org_study_id