Non-Cirrhotic Hyperammonemia Versus Hyperlactatemia in Septic Patients and Impact of Treatment
NCT ID: NCT06721845
Last Updated: 2024-12-06
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
60 participants
OBSERVATIONAL
2023-07-01
2024-09-30
Brief Summary
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Background: Sepsis is associated with amino acid flux towards the liver, which increases the ammonia load. The combination of decreased clearance and increased load is thought to be the major cause of increased ammonia in sepsis.
Methodology: 60 septic patients were classified into 2 equal groups, Group I: Septic patients with positive microbial cultures. Group II: septic patients with negative cultures enrolled to obtain serum ammonia and lactic acid levels on admission and every six hours for three days. The primary outcome was to detect ammonia specificity and sensitivity in predicting sepsis in comparison to lactate. The secondary outcomes were need for mechanical ventilation, mortality, and length of stay (LHS) within the intensive care unit.
Detailed Description
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The septic patients were classified into 2 equal groups, Group I: Septic patients with positive microbial cultures. Group II: septic patients with negative cultures enrolled to obtain serum ammonia and lactic acid levels on admission and every six hours for three days, to detect ammonia specificity and sensitivity in predicting sepsis in comparison to lactate. also, need for mechanical ventilation, mortality, and length of stay (LHS) within the intensive care unit were reported.
Conditions
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Keywords
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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Group I: Septic patients with positive microbial cultures.
No interventions assigned to this group
Group II: septic patients with negative microbial culture
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* both sexes with severe sepsis and septic shock
* within the first 48 hours of ICU admission
Exclusion Criteria
* Renal failure, Ureterosigmoidostomy,
* Malignancy or on Chemotherapy,
* Pregnancy,
* Parenteral nutrition,
* Autoimmune diseases or Immunosuppressive illness, and
* Trauma
19 Years
75 Years
ALL
No
Sponsors
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Menoufia University
OTHER
Responsible Party
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ashraf magdy eskandr
professor of anesthesia, ICU, Pain Management
Locations
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Menoufia Faculty of Medicine
Shibin Elkoom, Menoufia, Egypt
Countries
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Other Identifiers
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6/2023, ANET40
Identifier Type: -
Identifier Source: org_study_id