The RELIEF™ Ureteral Stent Randomized Controlled Trial

NCT ID: NCT06720740

Last Updated: 2024-12-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

50 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-12-01

Study Completion Date

2025-12-31

Brief Summary

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Assessment of the backwards flow of urine from the bladder into the ureter (retrograde urine reflux) after placement of the RELIEF® Ureteral Stent using imaging of the bladder after filling it with contrast and assigning a urinary reflux grade. Randomized controlled trial for evaluation of the stent placement and the adequacy of short term drainage (defined as the presence of the stent in the ureter and the lack of surgical or standard of care double J stent to treat symptoms associated with the stent itself on the stented side during the first 48 hours).

Detailed Description

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Conditions

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Kidney Stone

Keywords

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ureteral stent

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Standard of Care Ureteral Stent

Group Type ACTIVE_COMPARATOR

Standard of Care Ureteral Stent

Intervention Type DEVICE

The control product is the Ascerta stent by Boston Scientific.

RELIEF Ureteral Stent

Group Type EXPERIMENTAL

RELIEF Ureteral Stent

Intervention Type DEVICE

The study intervention is placement of the RELIEF Ureteral Stent

Interventions

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RELIEF Ureteral Stent

The study intervention is placement of the RELIEF Ureteral Stent

Intervention Type DEVICE

Standard of Care Ureteral Stent

The control product is the Ascerta stent by Boston Scientific.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Has capacity to consent
* Stated willingness to comply with all study procedures and availability for the duration of the study
* Persons, 18 years of age or older
* Male or female subjects with confirmed ureteral and/or renal stones or strictures documented via abdomen X-ray KUB (kidney ureter bladder) or CT (computed tomography)

Exclusion Criteria

* Distal ureteral obstruction where suture portion of stent may be placed
* Urinary reflux (assessed by pre-stent cystogram)
* Pregnancy or lactation
* Patients requiring bilateral surgical stone management procedure
* Infected stones
* Patients where 24cm or 26cm stent lengths are not suitable
* Ureteral structure in distal third of ureter
* Intraoperative exclusion: based on urologist's discretion, if trauma has been induced to the distal ureter due to ureteroscopy maneuvers, exclude these patients
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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The Ureteral Stent Company

UNKNOWN

Sponsor Role collaborator

University of California, San Diego

OTHER

Sponsor Role lead

Responsible Party

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Seth Bechis

Associate Professor of Urology

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Seth K Bechis, MD

Role: PRINCIPAL_INVESTIGATOR

University of California, San Diego

Central Contacts

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Jamie L Finegan, BA

Role: CONTACT

Phone: 858-777-9721

Email: [email protected]

Seth K Bechis, MD

Role: CONTACT

Email: [email protected]

References

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Chew BH, Knudsen BE, Denstedt JD. The use of stents in contemporary urology. Curr Opin Urol. 2004 Mar;14(2):111-5. doi: 10.1097/00042307-200403000-00011.

Reference Type BACKGROUND
PMID: 15075840 (View on PubMed)

Joshi HB, Okeke A, Newns N, Keeley FX Jr, Timoney AG. Characterization of urinary symptoms in patients with ureteral stents. Urology. 2002 Apr;59(4):511-6. doi: 10.1016/s0090-4295(01)01644-2.

Reference Type BACKGROUND
PMID: 11927301 (View on PubMed)

Chambade D, Thibault F, Niang L, Lakmichi MA, Gattegno B, Thibault P, Traxer O. [Study of the safety of double J ureteric stents]. Prog Urol. 2006 Sep;16(4):445-9. French.

Reference Type BACKGROUND
PMID: 17069037 (View on PubMed)

Shao Y, Shen ZJ, Zhuo J, Liu HT, Yu SQ, Xia SJ. The influence of ureteral stent on renal pelvic pressure in vivo. Urol Res. 2009 Aug;37(4):221-5. doi: 10.1007/s00240-009-0199-z. Epub 2009 Jun 10.

Reference Type BACKGROUND
PMID: 19513705 (View on PubMed)

Giannarini G, Keeley FX Jr, Valent F, Manassero F, Mogorovich A, Autorino R, Selli C. Predictors of morbidity in patients with indwelling ureteric stents: results of a prospective study using the validated Ureteric Stent Symptoms Questionnaire. BJU Int. 2011 Feb;107(4):648-54. doi: 10.1111/j.1464-410X.2010.09482.x.

Reference Type BACKGROUND
PMID: 20590539 (View on PubMed)

Krebs A, Deane LA, Borin JF, Edwards RA, Sala LG, Khan F, Abdelshehid C, McDougall EM, Clayman RV. The 'buoy' stent: evaluation of a prototype indwelling ureteric stent in a porcine model. BJU Int. 2009 Jul;104(1):88-92. doi: 10.1111/j.1464-410X.2008.08338.x. Epub 2009 Jan 14.

Reference Type BACKGROUND
PMID: 19154469 (View on PubMed)

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Document Type: Informed Consent Form

View Document

Other Identifiers

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809792

Identifier Type: -

Identifier Source: org_study_id