Comparative Study Between the Analgesic Effect of Dexmedetomidine and Magnesium Sulfate As Adjuvant to Bupivacaine Using Ultrasound-Guided Transversus Abdominis Plane Block in Abdominal Hysterectomy : a Randomized Double-blinded Study
NCT ID: NCT06720337
Last Updated: 2024-12-06
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
PHASE4
64 participants
INTERVENTIONAL
2025-01-01
2026-02-01
Brief Summary
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Additionally, if pain is not promptly managed after surgery, it can hinder a patient's ability to walk, potentially causing adverse effects such as thromboembolism, myocardial ischemia, and arrhythmia.
The opioid analgesics are most commonly used as parenteral agents to manage post operative pain but the problem of respiratory depression remains to be considered.
This study is designed to compare the analgesic effect between dexmedetomidine versus magnesium sulfate as adjuvant to bupivacaine using ultrasound guided Transversus Abdominis Plane block in patients undergoing abdominal hysterectomy
Detailed Description
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Numerous studies have demonstrated that when enhanced recovery procedures (ERPs) are used, hospital length of stay, time to return to normal function, postoperative ileus duration, thromboembolic complications, morbidity, and all of these factors are all reduced. In order to achieve the best pain treatment, many ERPs use a multimodal approach, decreasing the use of opioids as the primary analgesic in Favor of neuraxial and regional anaesthetic techniques.
One of the regional techniques routinely used is the transversus abdominis plane (TAP) block. Its widespread use in abdominal surgeries is due to its technical simplicity and trustworthy analgesia.
Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
QUADRUPLE
Study Groups
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group A
Patients will receive 18 ml 0.5% bupivacaine (Sunnypivacaine®) plus 0.5 µg/kg of dexmedetomidine (Precedex® 100 µg/ml) diluted in 2 ml of normal saline at each side
bupivacaine 0.5%
patients will receive 18 ml 0.5% bupivacaine (Sunnypivacaine®) using Ultrasound-Guided TAP Block Technique
Dexmedetomidine
patients will receive plus 0.5 µg/kg of dexmedetomidine (Precedex® 100 µg/ml) diluted in 2 ml of normal saline at each side
group b
patients will receive 18 ml 0.5% bupivacaine (Sunnypivacaine®) plus 1.5 mL (150 mg) MgSO4 and 0.5 mL normal saline at each side
bupivacaine 0.5%
patients will receive 18 ml 0.5% bupivacaine (Sunnypivacaine®) using Ultrasound-Guided TAP Block Technique
MgSO4
patients will receive plus 1.5 mL (150 mg) MgSO4 and 0.5 mL normal saline at each side
Interventions
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bupivacaine 0.5%
patients will receive 18 ml 0.5% bupivacaine (Sunnypivacaine®) using Ultrasound-Guided TAP Block Technique
Dexmedetomidine
patients will receive plus 0.5 µg/kg of dexmedetomidine (Precedex® 100 µg/ml) diluted in 2 ml of normal saline at each side
MgSO4
patients will receive plus 1.5 mL (150 mg) MgSO4 and 0.5 mL normal saline at each side
Eligibility Criteria
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Inclusion Criteria
* Aged \>18 years,
* weight 50-85 kg,
* Patients who will undergo total abdominal hysterectomy
Exclusion Criteria
* Aged \>18 years,
* weight 50-85 kg,
* Patients who will undergo total abdominal hysterectomy
18 Years
ALL
No
Sponsors
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Assiut University
OTHER
Responsible Party
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Abdelrahman Mahfouz Ali
resident doctor at Anaesthesia, Intensive Care and Pain Management department Faculty of Medicine, Assiut University
Central Contacts
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Abdelrahman Mahfouz Ali, resident doctor
Role: CONTACT
Phone: +2 01023864487
Email: [email protected]
References
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Yu N, Long X, Lujan-Hernandez JR, Succar J, Xin X, Wang X. Transversus abdominis-plane block versus local anesthetic wound infiltration in lower abdominal surgery: a systematic review and meta-analysis of randomized controlled trials. BMC Anesthesiol. 2014 Dec 15;14:121. doi: 10.1186/1471-2253-14-121. eCollection 2014.
Other Identifiers
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Dexmedetomidine and Mgso4 TAP
Identifier Type: -
Identifier Source: org_study_id