Resistance Exercise Volume and Hypertrophic Response Variability in Elderly

NCT ID: NCT06718712

Last Updated: 2024-12-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

102 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-04-01

Study Completion Date

2018-12-20

Brief Summary

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The study aimed to investigate the effects of resistance training volume manipulation on whole muscle hypertrophy among non-responders and responders to a low resistance training dose (single-set).

Detailed Description

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The magnitude of muscle hypertrophy in response to resistance training (RT) is highly variable between individuals (response heterogeneity). Manipulations in RT variables may modulate RT-related response heterogeneity; yet, this remains to be determined.

Conditions

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Aging Muscle Hypertrophy

Keywords

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aging muscle mass muscle strength resistance exercise sets

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Lower body unilateral design
Primary Study Purpose

OTHER

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Single set

One set of unilateral knee-extension exercise of 8-15 RM with a 60-90 s interval.

Group Type EXPERIMENTAL

Lower body resistance training

Intervention Type OTHER

The RT protocol was performed using a unilateral knee-extension machine. To reduce potential sources of bias to exercise order, subjects alternated the starting leg for each training session.

Four sets

Four sets of unilateral knee-extension exercise of 8-15 RM with a 60-90 s interval between sets.

Group Type EXPERIMENTAL

Lower body resistance training

Intervention Type OTHER

The RT protocol was performed using a unilateral knee-extension machine. To reduce potential sources of bias to exercise order, subjects alternated the starting leg for each training session.

Interventions

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Lower body resistance training

The RT protocol was performed using a unilateral knee-extension machine. To reduce potential sources of bias to exercise order, subjects alternated the starting leg for each training session.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* 60 years and older
* not engaged in regular resistance and/or aerobic training for at least six months before the intervention

Exclusion Criteria

* diagnosed type I diabetes mellitus
* arrhythmia
* noncontrolled hypertension
* any major orthopedic musculoskeletal condition
* use of any dietary supplement or drug with potential anabolic effects
Minimum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Sao Paulo

OTHER

Sponsor Role collaborator

University of Sao Paulo General Hospital

OTHER

Sponsor Role lead

Responsible Party

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Hamilton Augusto Roschel da Silva

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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University of Sao Paulo

São Paulo, São Paulo, Brazil

Site Status

Countries

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Brazil

Other Identifiers

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62590416.0.0000.5391

Identifier Type: -

Identifier Source: org_study_id