Impacts of Nitrogen Deposition in the Natural Environment on Pollen Allergy in Belgium
NCT ID: NCT06714149
Last Updated: 2024-12-03
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
200 participants
INTERVENTIONAL
2022-06-29
2025-04-30
Brief Summary
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Detailed Description
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* To study the basophil degranulation with different amounts of pollen on fresh patient-derived basophils, to determine the concentration of pollen needed to degranulate 5% (EC5), and 50% (EC50) of basophils.
* To study he overall intensity (quantitative), as well as IgE-mediated hyper- or hyporecognition of different fragments in the pollen samples (qualitative) in a subset of patients.
* To associate allergic rhinoconjunctivitis and food-pollen syndrome related symptoms with reactivity to different pollen samples.
Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
BASIC_SCIENCE
NONE
Study Groups
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Allergic subjects
All subject with positive skin prick testing for grass and/or birch pollen are assigned to this group.
Immunoreactivity testing
Blood samples will be collected and used to determine the intensity of the allergenicity of the subject toward different types of pollen. This will be done by the detection of sIgE antibodies to the pollen extracts and basophil activation testing (BAT) with pollen extracts.
Healthy controls
Subjects with negative skin prick testing for grass and/or birch pollen are assigned to this group and used for as negative controls in our experiments.
Immunoreactivity testing (negative control)
Blood samples will be collected and used to determine the background activity of our immunoreactivity tests. The investigators will use samples from negative controls to demonstrate that non-allergic individuals do not react to our assays, confirming that our pollen extracts have no background reactivity. This will be done by the detection of sIgE antibodies to the pollen extracts and basophil activation testing (BAT) with pollen extracts.
Interventions
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Immunoreactivity testing
Blood samples will be collected and used to determine the intensity of the allergenicity of the subject toward different types of pollen. This will be done by the detection of sIgE antibodies to the pollen extracts and basophil activation testing (BAT) with pollen extracts.
Immunoreactivity testing (negative control)
Blood samples will be collected and used to determine the background activity of our immunoreactivity tests. The investigators will use samples from negative controls to demonstrate that non-allergic individuals do not react to our assays, confirming that our pollen extracts have no background reactivity. This will be done by the detection of sIgE antibodies to the pollen extracts and basophil activation testing (BAT) with pollen extracts.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
18 Years
ALL
Yes
Sponsors
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Sciensano
OTHER_GOV
KU Leuven
OTHER
University of Namur
OTHER
Université Catholique de Louvain
UNKNOWN
prof. dr. Rik Schrijvers
OTHER
Responsible Party
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prof. dr. Rik Schrijvers
Prof. dr.
Locations
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University Hospitals Leuven
Leuven, Vlaams-Brabant, Belgium
Countries
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Central Contacts
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Facility Contacts
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References
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Verscheure P, Honnay O, Speybroeck N, Daelemans R, Bruffaerts N, Devleesschauwer B, Ceulemans T, Van Gerven L, Aerts R, Schrijvers R. Impact of environmental nitrogen pollution on pollen allergy: A scoping review. Sci Total Environ. 2023 Oct 1;893:164801. doi: 10.1016/j.scitotenv.2023.164801. Epub 2023 Jun 14.
Ceulemans T, Verscheure P, Shadouh C, Van Acker K, Devleesschauwer B, Linard C, Dendoncker N, Speybroeck N, Bruffaerts N, Honnay O, Schrijvers R, Aerts R. Environmental degradation and the increasing burden of allergic disease: The need to determine the impact of nitrogen pollution. Front Allergy. 2023 Feb 2;4:1063982. doi: 10.3389/falgy.2023.1063982. eCollection 2023. No abstract available.
Other Identifiers
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B2/212/P1/NITROPOL-BE
Identifier Type: OTHER_GRANT
Identifier Source: secondary_id
S65184
Identifier Type: -
Identifier Source: org_study_id