Relation of C-reactive Protein/ Albumin Ratio and Coagulation Profile in Acute Myeloid Leukemia Patients

NCT ID: NCT06714071

Last Updated: 2025-01-28

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Total Enrollment: 80 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2025-04-30
• Study Completion Date: 2027-05-01

Brief Summary

The investigators will investigate the relation between CAR and coagulation profile in newly diagnosed AMl patients

Detailed Description

Acute myeloid leukaemia (AML) is an aggressive haematological malignancy with a high degree of heterogeneity. It has long been recognized that systemic inflammation is associated with tumorigenesis it revealed that elevated C-reactive protein levels were associated with worse survival outcomes in patients with various types of cancer, including hematologic malignancies. Serum albumin is a measure of an individual's nutritional status. Systemic inflammation can reduce serum albumin concentrations by increasing capillary permeability . The ratio of CRP to albumin (CAR) is a useful score based on inflammation and nutrition, reflecting not only systemic inflammation status but also nutritional status. The Glasgow prognostic score (GPS) and modified GPS (mGPS), determined by the serum CRP and albumin levels, have been proposed as prognostic indicators for AML patients. However, the clinical correlations of CAR and its prognostic value in AML patients have not yet been clarified. Abnormalities of hemostasis can occur in leukemia in the form of disseminated intravascular coagulation(DIC), coagulation protein defect and primary fibrinolysis . Clinically, Types of acute myeloid leukemia like acute promyelocyticleukemia has a high frequency of haemorrhage due to disseminated intravascular coagulation (DIC), which contributes to the high mortality rate of this disease . Therefore, the investigators will investigate CAR its relation with inflammatory response and coagulation profile levels in newly diagnosed acute myeloid leukemia and after 3 month follow up to compare their level and the relation between .

Conditions

AML

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Interventions

CRP and Albumin and coagulation profile

CRP and Albumin and coagulation profile

Intervention Type: DIAGNOSTIC_TEST

Eligibility Criteria

Inclusion Criteria

• all cases newly diagnosed with acute myeloid leukemiain assuit university hospital

Exclusion Criteria

1. cases with chronic myeloid leukemia

2. cases with acute lymphoblasticleukemia

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 90 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Assiut University

OTHER

Sponsor Role: lead

Responsible Party

shrouk mosallam ahmed khalaf

doctor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

sohir kamel, prof

Role: STUDY_DIRECTOR

Director

Locations

Assiut University

Asyut, , Egypt

Countries

Egypt

Central Contacts

shrouk mosallam, master

Role: CONTACT

shrouqmosllam@gmail.com

01014396113

hebatallah addellatif, prof

Role: CONTACT

hebatallah.abdellatif@aun.edu.eg

01006829911

Other Identifiers

aml and crp/albumin ratio

Identifier Type: -

Identifier Source: org_study_id