Extracellular Vesicles in Fibrin Gel for Cartilage Repair
NCT ID: NCT06713902
Last Updated: 2024-12-03
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
51 participants
OBSERVATIONAL
2024-10-29
2026-08-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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COHORT
CROSS_SECTIONAL
Study Groups
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Fifty-one m/f patients matching the inclusion and exclusion criteria
Six patients undergoing plastic surgery procedures for the removal of adipose tissue from which waste material (adipose tissue) will be taken to obtain MSCs for EVs production. Five patients undergoing hip or knee joint replacement surgery from which waste material (osteo-cartilaginous material) will be taken to obtain chondrocytes for functional tests. Forty patients undergoing regenerative medicine treatments with PRP from which a waste aliquot (obtained during PRP preparation) will be taken to obtain plasma for fibrin gel production.
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* patients undergoing plastic surgery procedures;
* patients undergoing elective joint surgery with a diagnosis of knee or hip osteoarthritis (any Kellgren-Lawrence grade);
* patients undergoing regenerative medicine treatments with PRP with a diagnosis of knee or hip osteoarthritis (any Kellgren-Lawrence grade;
* signed Informed Consent for the study
Exclusion Criteria
* Pregnancy or breastfeeding by self-declaration
* Other conditions that, at the discretion of the investigator or the physician
18 Years
ALL
No
Sponsors
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I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
OTHER
Responsible Party
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Locations
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I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Milan, MI, Italy
Countries
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Central Contacts
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Facility Contacts
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References
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Ragni E, De Luca P, Landoni S, Valli F, Mortati L, Palombella S, Talo G, Moretti M, de Girolamo L. High efficiency protocol for platelet derived fibrin gel loaded with mesenchymal stromal cells extracellular vesicles. Regen Ther. 2024 Jul 7;26:442-457. doi: 10.1016/j.reth.2024.06.020. eCollection 2024 Jun.
Other Identifiers
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GelVex
Identifier Type: -
Identifier Source: org_study_id