Effectiveness of Enhanced External Counterpulsation for Post-acute Stroke Patients

NCT ID: NCT06711003

Last Updated: 2024-12-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

110 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-10-22

Study Completion Date

2025-05-15

Brief Summary

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The goal of this clinical trial is to learn if there benefits combine enhanced external counterpulsation (EECP) with the standard post-acute care (PAC) rehabilitation treatment to treat stroke patients.. The main questions it aims to answer are:

What is the feasibility of combining EECP and PAC? Does EECP combined PAC rehabilitation improve functional outcomes of post-stroke patients? Researchers will compare standard PAC rehabilitation and EECP combined PAC rehabilitation to see if EECP has benefits to treat stroke.

Detailed Description

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Conditions

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Cerebrovascular Accident (CVA)

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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EECP+PAC

Patients receive 35 times EECP treatments during standard PAC program.

Group Type EXPERIMENTAL

enhanced external counterpulsation

Intervention Type DEVICE

Enhanced External Counterpulsation (EECP) is a non-invasive treatment primarily used for patients with angina or heart failure. It involves the application of pressure cuffs to the legs, which inflate and deflate in sync with the cardiac cycle. This enhances blood flow to the heart during diastole, the phase when the heart is resting between beats. The increased pressure promotes coronary artery perfusion, helping to improve oxygen delivery to the heart muscle, reduce angina symptoms, and enhance cardiovascular function. EECP is typically recommended for patients who are not good candidates for invasive procedures like angioplasty or bypass surgery, or for those seeking supplementary treatment for angina. Over time, it may promote the development of new blood vessels (collateral circulation), further improving heart health. The treatment is generally administered over several weeks in outpatient settings, with each session lasting around one hour.

post acute care

Intervention Type PROCEDURE

Post-Acute Care (PAC) for stroke patients focuses on improving functional independence, reducing disability, and preventing secondary complications.

PAC

Patients receive standard PAC program.

Group Type ACTIVE_COMPARATOR

post acute care

Intervention Type PROCEDURE

Post-Acute Care (PAC) for stroke patients focuses on improving functional independence, reducing disability, and preventing secondary complications.

Interventions

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enhanced external counterpulsation

Enhanced External Counterpulsation (EECP) is a non-invasive treatment primarily used for patients with angina or heart failure. It involves the application of pressure cuffs to the legs, which inflate and deflate in sync with the cardiac cycle. This enhances blood flow to the heart during diastole, the phase when the heart is resting between beats. The increased pressure promotes coronary artery perfusion, helping to improve oxygen delivery to the heart muscle, reduce angina symptoms, and enhance cardiovascular function. EECP is typically recommended for patients who are not good candidates for invasive procedures like angioplasty or bypass surgery, or for those seeking supplementary treatment for angina. Over time, it may promote the development of new blood vessels (collateral circulation), further improving heart health. The treatment is generally administered over several weeks in outpatient settings, with each session lasting around one hour.

Intervention Type DEVICE

post acute care

Post-Acute Care (PAC) for stroke patients focuses on improving functional independence, reducing disability, and preventing secondary complications.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Patients with acute cerebrovascular disease, within 1 month after acute attack.
* Stable medical condition: (1). Neurological condition: The neurological condition has not deteriorated for more than 72 hours. (2). Vital signs including blood pressure, heartbeat, and body temperature are stable or controllable for more than 72 hours. (3). No complications such as infection, blood abnormalities, gastrointestinal bleeding, or stable or controllable after treatment.
* Those whose functional status is moderate to moderately severe functional impairment (MRS 3-4) and who are judged by the medical team to have active rehabilitation potential: (1). Have basic cognition, learning ability and willingness. (2) Have sufficient physical strength: able to maintain a sitting position on a wheelchair or bed edge for at least one hour with support. (3). Be able to actively participate in rehabilitation treatment plans.
* Aged over 20 years old

Exclusion Criteria

* Patients with atrial fibrillation/arrhythmia.
* Within 2 weeks after cardiac catheterization or arterial puncture at the femoral artery puncture site.
* Decompensated heart failure (NYHA class 3 or 4).
* Left ventricular ejection fraction (EF) \< 30%.
* Moderate or severe aortic regurgitation.
* Persistent and uncontrolled hypertension (blood pressure persistently \>160/100 mmHg).
* Bleeding tendency.
* Active phlebitis/venous disease of the lower extremities.
* Severe vascular occlusive disease of the lower extremities.
* The presence of documented aortic aneurysm/dissection requiring surgical repair.
* Pregnancy.
Minimum Eligible Age

20 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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China Medical University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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China Medical University Hospital Taichung East District Branch

Taichung, , Taiwan

Site Status RECRUITING

Countries

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Taiwan

Central Contacts

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Li-Wei Chou, PhD

Role: CONTACT

886+975681612

Facility Contacts

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Li-Wei Chou

Role: primary

886+975681612

Other Identifiers

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CMUH113-REC3-136

Identifier Type: -

Identifier Source: org_study_id