A Study on the Safety of Deucravacitinib Exposure in Pregnant Women and Their Offspring

NCT ID: NCT06710470

Last Updated: 2024-11-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

833 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-08-02

Study Completion Date

2029-02-28

Brief Summary

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This observational study aims to assess pregnancy and infant outcomes among pregnant women with psoriasis who have been exposed to deucravacitinib treatment in the USA.

Detailed Description

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Conditions

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Psoriasis

Keywords

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Psoriasis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Cohort 1

Participants exposed to deucravacitinib for the full pregnancy duration

Deucravacitinib

Intervention Type DRUG

As per product label

Cohort 2

Participants exposed to deucravacitinib for the first trimester

Deucravacitinib

Intervention Type DRUG

As per product label

Cohort 3

Participants exposed to deucravacitinib for the first 20 weeks of gestation

Deucravacitinib

Intervention Type DRUG

As per product label

Cohort 4

Participants exposed to other systemic psoriasis medications for the full pregnancy duration

Systemic psoriasis medications

Intervention Type DRUG

As per product label

Cohort 5

Participants exposed to other systemic psoriasis medications for the first trimester

Systemic psoriasis medications

Intervention Type DRUG

As per product label

Cohort 6

Participants exposed to other systemic psoriasis medications for the first 20 weeks of gestation

Systemic psoriasis medications

Intervention Type DRUG

As per product label

Cohort 7

Participants not exposed to any systemic medications for the full pregnancy duration

No systemic medications

Intervention Type OTHER

Participants not exposed to any systemic medications

Cohort 8

Participants not exposed to any systemic medications during the first trimester

No systemic medications

Intervention Type OTHER

Participants not exposed to any systemic medications

Cohort 9

Participants not exposed to any systemic medications during the first 20 weeks of gestation

No systemic medications

Intervention Type OTHER

Participants not exposed to any systemic medications

Interventions

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Deucravacitinib

As per product label

Intervention Type DRUG

Systemic psoriasis medications

As per product label

Intervention Type DRUG

No systemic medications

Participants not exposed to any systemic medications

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Maternal age 15 through 50 years at date of conception
* Start of pregnancy, defined as the estimated date of conception, during the accrual period (09-Sep-2022 through 31-Oct-2026)
* Continuous medical and pharmacy coverage for a minimum of 6 months prior to and including the estimated date of conception
* Presence of psoriasis from 12 months prior to the date of conception through the end of pregnancy

Exclusion Criteria

• Exposure to any known teratogens from 5 half-lives prior to the estimated date of conception through the end of the relevant exposure window
Minimum Eligible Age

15 Years

Maximum Eligible Age

50 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Bristol-Myers Squibb

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Bristol-Myers Squibb

Role: STUDY_DIRECTOR

Bristol-Myers Squibb

Locations

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Bristol-Meyers Squibb

Lawrenceville, New Jersey, United States

Site Status

Countries

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United States

Related Links

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Other Identifiers

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IM011-201

Identifier Type: -

Identifier Source: org_study_id