Study of SC-102 in Patients With Advanced Solid Tumors

NCT ID: NCT06710158

Last Updated: 2025-07-29

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: PHASE1
• Total Enrollment: 120 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2024-12-05
• Study Completion Date: 2027-06-30

Brief Summary

This study will evaluate the safety, PK profile, and anti-cancer efficacy of SC-102 in subjects with advanced solid tumors

Detailed Description

SC-102 is a peptide drug conjugate (PDC) consisting of an EphA2-targeting peptide, a tubulin inhibitor, and a protease-hydrolysable linker.

This phase I multi-center, open-label first-in-human trial, including a dose escalation study and a dose expansion study, will evaluate SC-102 administrated once weekly or biweekly as a single agent in patients with advanced solid tumors. The dose escalation study is primarily designed to assess the safety and tolerability of SC-102 and to determine the recommended dose(s) for the dose expansion study. The dose expansion study is designed with the primary objective of evaluating the clinical activity of SC-102.

Conditions

Advanced Solid Cancers

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: SEQUENTIAL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

SC-102 for once weekly

Participants will receive SC-102 as a single agent once weekly on a 4-week cycle at the selected dose.

Group Type: EXPERIMENTAL

SC-102

Intervention Type: DRUG

SC-102 is a peptide drug conjugate (PDC) consisting an EphA2-targeting peptide, a tubulin inhibitor, and a protease-hydrolyzable linker.

SC-102 for once biweekly

Participants will receive SC-102 as a single agent once biweekly on a 4-week cycle at the selected dose.

Group Type: EXPERIMENTAL

SC-102

Intervention Type: DRUG

SC-102 is a peptide drug conjugate (PDC) consisting an EphA2-targeting peptide, a tubulin inhibitor, and a protease-hydrolyzable linker.

Interventions

SC-102

SC-102 is a peptide drug conjugate (PDC) consisting an EphA2-targeting peptide, a tubulin inhibitor, and a protease-hydrolyzable linker.

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

1. Subjects voluntarily agree to participate in the study and sign the Informed Consent Form (ICF).

2. Aged 18 to 75 years at the time of signature of the ICF, without gender limitation.

3. Eastern Cooperative Oncology Group (ECOG) Performance Status score of 0 or 1.

4. Life expectancy of ≥ 3 months as assessed by the investigator.

5. Women and men of childbearing potential must be advised and agree to practice effective methods of contraception during the study.

6. Must be willing and able to comply with the protocol and study procedures.

7. Acceptable renal, hepatic, hematologic, and coagulation functions.

8. Measurable disease per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1.

9. Metastatic recurrent histologically confirmed malignant solid tumors and exhausted all appropriate treatment options per local guidelines.

10. Confirmation of EphA2 expression by the central laboratory prior to enrollment is not required for participants enrolled in the dose escalation study, but required for participants enrolled in the dose expansion study.

Exclusion Criteria

1. History of other malignancy(ies) within 3 years before signing the ICF, except for cured basal cell carcinoma or squamous cell carcinoma of the skin, carcinoma in situ of the cervix, papillary carcinoma of the thyroid gland, carcinoma in situ of the duct in situ, or other malignant tumors that have survived without disease for more than 5 years.

2. Any anticancer treatment, including experimental treatments, within 4 weeks before the first dose of the study drug.

3. Radiotherapy to >30% of the bone marrow or extensive radiotherapy within 4 weeks, or local radiotherapy (e.g., radiation therapy to the thoracic spine and ribs) within 7 days, prior to the first dose of the study drug.

4. Uncontrolled central nervous system metastases.

5. Preexisting treatment-related toxicity Grade ≥ 2 (except Grade 2 alopecia and hypothyroidism stable with hormone replacement therapy).

6. Preexisting Grade ≥ 2 (as per CTCAE v5.0) sensory or motor neuropathy.

7. Major surgery within 4 weeks prior to the first dose of the study drug.

8. History of interstitial lung disease (ILD), preexisting ILD, or the suspected ILD that cannot be ruled out by imaging examination at screening.

9. Preexisting serious dermatological diseases, or having experienced serious skin toxicities during the prior anti-cancer treatment (e.g., Stevens-Johnson syndrome, toxic Epidermal Necrolysis, etc.).

10. Active infection requiring systemic therapy within 14 days prior to the first dose of the study drug.

11. History of thromboembolic events and bleeding disorders ≤ 3 months (e.g., deep vein thrombosis (DVT) or pulmonary embolism (PE)) prior to the first dose of the study drug.

12. Positive results of virus serology tests.

13. History of serious cardiovascular and cerebrovascular diseases.

14. Has received treatment within 2 weeks prior to the first dose of the study drug, or requires ongoing treatment with a medication that is a strong inhibitor or inducer of the cytochrome P450 3A4 (CYP3A4) enzymes.

15. Known sensitivity to any of the ingredients of the investigational product.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Tianjin ConjuStar Biologics Co., Ltd.

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Fudan University Shanghai Cancer Center

Shanghai, Shanghai Municipality, China

Site Status: RECRUITING

Countries

China

Central Contacts

Jing Wu

Role: CONTACT

wujing@conjustar.com

086-21-33670866

Other Identifiers

SC-102-101

Identifier Type: -

Identifier Source: org_study_id