Efficacy of Domperidone (a Prokinetic Agent) on Time in Range in Digestively Asymptomatic Type I Diabetic Patients with Delayed Gastric Emptying (Gastro-TIR)

NCT ID: NCT06695962

Last Updated: 2024-11-19

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Clinical Phase: PHASE3
• Total Enrollment: 70 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2025-03-01
• Study Completion Date: 2028-07-01

Brief Summary

Patients living with type 1 diabetes PwT1D) still have trouble controlling their blood sugar, even with the latest treatments. PwT1D may have slow stomach emptying influencing blood glucose level. Treating this is an important goal. A recent study found that 30% of PwT1D had a slower gastric emptying rate, even though they had no other complications and were not experiencing any digestive issues. Slowing of gastric emptying is linked to gastric hypoglycaemia, which is a life-threatening condition that can affect quality of life, and to higher blood sugar level after eating. This can last throughout the night. Prokinetic treatments for the stomach are good for diabetic patients with slow digestion. They help with stomach pain and, to a lesser extent, with hypoglycemia. However, there is no data on the benefits of such treatments in patients with no digestive symptoms, on glycaemic control as defined by continuous glucose monitoring data. In fact, this may be more relevant than HbA1c in patients with alternating hypo- and/or hyperglycaemia.

We think that a prokinetic agent like domperidone could improve glycaemic control in PwT1D with slow gastric emptying and glycaemic imbalance.

This study tests how domperidone affects blood sugar levels in PwT1D. Patients will be administrated domperidone or a placebo for 28 days. We will see how long T1D patients spend within their blood sugar target range over 14 days using a continuous glucose monitor.

Conditions

Type 1 Diabetic

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: TREATMENT
• Blinding Strategy: QUADRUPLE

Study Groups

Domperidone then placebo

Domperidone 10 mg, 3/days during 28 days, - wash-out (21 days) then placebo 3/days during 28 days

Group Type: EXPERIMENTAL

Domperidone 10mg

Intervention Type: DRUG

30 mg per day for 21 days

Placebo

Intervention Type: DRUG

3 per day for 21 days

gastric emptying test

Intervention Type: DIAGNOSTIC_TEST

gastric emptying test

Placebo then Domperidone

Placebo 3/days during 28 days - wash-out (21 days) - then Domperidone 10 mg, 3/days during 28 days

Group Type: EXPERIMENTAL

Domperidone 10mg

Intervention Type: DRUG

30 mg per day for 21 days

Placebo

Intervention Type: DRUG

3 per day for 21 days

gastric emptying test

Intervention Type: DIAGNOSTIC_TEST

gastric emptying test

Interventions

Domperidone 10mg

30 mg per day for 21 days

Intervention Type: DRUG

Placebo

3 per day for 21 days

Intervention Type: DRUG

gastric emptying test

gastric emptying test

Intervention Type: DIAGNOSTIC_TEST

Eligibility Criteria

Inclusion Criteria

• Male or female ≥ 18 years and <75 years
• Known type 1 diabetic patients for > 5 years treated with multi-injection insulin regimen or insulin pump with continuous interstitial glucose recording device (CGM)
• Type 1 diabetic patients with glycemic target TIR (70-180 mg/dL) < 60% and/or CV > 40% and/or early postprandial hypoglycemia
• Patient with few symptoms of gastroparesis based on GCSI score ≤ 2
• Person who has read and understood the information letter and signed the consent form
• Person affiliated to a social security scheme
• A woman of childbearing potential (a woman is considered to be of childbearing potential fertile, after menarche and until she reaches menopause, unless she has reached the menopausal, unless she is definitively sterile)with at least effective contraception (i.e. at least: oral progestin-only hormonal contraception for which ovulation inhibition is not the primary mode of action, male or female condom with or without spermicide, cap, diaphragm or sponge with spermicide). for at least 1 month and a negative urine B-HCG pregnancy test at inclusion
• Surgically sterile women (hysterectomy, bilateral salpingectomy and bilateral oophorectomy)
• Menopausal women: The postmenopausal state is defined as the absence of menstrual periods for 12 months without any other medical cause. An elevated follicle-stimulating hormone (FSH) level in the post-menopausalinterval can be used to confirm a post-menopausal state in women not using hormonal contraception or hormone replacement therapy. However, in the absence of 12 months' amenorrhea, a single FSH measurement is insufficient

Exclusion Criteria

• Type 2 diabetic patients
• Patients with CGM<70%
• Type 1 diabetic patients with glycemic target TIR (70-180 mg/dL) < 40%
• Patients with renal insufficiency (GFR<60 ml/min according to CKD-EPI formula),
• Patients with contraindications to DOMPERIDONE ARROW 10 mg film-coated tablet:

• Hypersensitivity to the active substance or to one of the excipients
• Pituitary prolactin tumor (prolactinoma)
• Underlying heart disease such as congestive heart failure (NYHA stage ≥2),
• Kalemia less than 3.7 mmol/L or greater than 5.5 mmol/L,
• Magnesemia less than 0.7 mmol/L
• Hepatic impairment (TGO, TGP, GGT>2N, TP<70% (unless on anticoagulant))
• Known prolongation of cardiac conduction intervals, notably the QTc interval (QTc greater than 440 ms for men and greater than 460 ms for women)
• Use of drugs that prolong the QTc interval (class IA antiarrhythmics (e.g. disopyramide, hydroquinidine, quinidine) and class III antiarrhythmics (e.g. amiodarone, dofetilide, dronedarone, ibutilide, sotalol), certain antipsychotics (e.g. haloperidol, pimozide, sertindole), certain antidepressants (e.g. citalopram, escitalopram), certain antibiotics (e.g. erythromycin, levifloxacin, moxifloxacin, spiramycin), certain antifungals (e.g. pentamidine, fluconazole), certain antimalarial drugs (in particular halofantrine, lumefantrine), certain digestive drugs (e.g. cisapride, dolasetron, prucalopride), certain antihistamines (e.g. mequitazine, mizolastine), certain anticancer drugs (e.g. toremifene, vandetanib, vincamine), certain other drugs (e.g. bepridil, diphemanil, methadone), apomorphine (unless the benefit of concomitant administration outweighs the risks, and only if the precautions recommended for concomitant administration are strictly observed).
• Taking levodopa
• Use of drugs that are potent or moderate inhibitors of CYP3A4: antiproteases, systemic azole antifungals, certain macrolide antibiotics (clarithromycin, telithromycin, azithromycin, roxithromycin, etc.), diltiazem, verapamil, etc.
• Bradycardia (< 50 bpm)
• Use ofmedication that induces bradycardia and hypokalemia
• Presence of gastrointestinal bleeding, mechanicalobstruction or digestive perforation
• Lactose contraindication: galactose intolerance, total lactase deficiency,glucose-galactose malabsorption syndrome
• Contraindication to gastric emptying test : - allergy to eggs, gluten, milk proteins, etc. - hepatic insufficiency - pulmonary diffusion disorders
• Contraindication to placebo (calcium content): hypercalcemia/hypercalciuria, known calcium lithiasis
• Pregnant, parturient or breast-feeding women, or those without proven effective contraception
• Person deprived of liberty by an administrative or judicial decision, or person under court protection, subguardianship or guardianship
• Person taking part in another trial / having taken part in another therapeutic trial (study involving a drug or medical device) which could interfere with the products or procedures being investigated within a period of 4 weeks prior to inclusion
• Any history of illness or psychological or sensory abnormality likely to prevent the subject from fully understanding the conditions required for participation in the protocol or from giving informed consent
• Patients treated with a closed insulin loop

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

University Hospital, Rouen

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

CHU Amiens

Amiens, , France

CHU de CAEN

Caen, , France

CH Dieppe

Dieppe, , France

Centre Hospitalier Intercommunal Elbeuf, Louviers, Val de Reuil

Elbeuf, , France

GH Le Havre

Le Havre, , France

CHU de ROUEN

Rouen, , France

Countries

France

Central Contacts

Gaetan PREVOST, Pr

Role: CONTACT

gaetan.prevost@chu-rouen.fr

232889061 ext. +33

Armelle Guidotti

Role: CONTACT

armelle.guidotti@chu-rouen.fr

232888265 ext. +33

Facility Contacts

Rachel DESAILLOUD, Pr

Role: primary

desailloud.rachel@chu-amiens.fr

322455478 ext. +33

Michael JOUBERT, Pr

Role: primary

joubert-m@chu-caen.fr

231064575 ext. +33

Caroline FOLOPPE, MD

Role: primary

cfoloppe@ch-dieppe.fr

232147557 ext. +33

Julie DROUHARD, MD

Role: primary

julie.drouhard@chi-elbeuf-louviers.fr

2 32 82 65 42 ext. +33

Clémence BURES, MD

Role: primary

clemence.bures@ch-havre.fr

2 32 73 31 09 ext. +33

Gaetan Prevost, Pr

Role: primary

gaetan.prevost@chu-rouen.fr

2 32 88 90 61 ext. +33

Other Identifiers

2021/0380/HP

Identifier Type: -

Identifier Source: org_study_id