Safety and Efficacy of SYHA1813 Single Agent or in Combination With Different Regimens in Unresectable Locally Advanced or Metastatic Solid Tumors.

NCT ID: NCT06682611

Last Updated: 2024-11-12

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Clinical Phase: PHASE1/PHASE2
• Total Enrollment: 380 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2024-11-13
• Study Completion Date: 2027-11-13

Brief Summary

This is an open-label, multi-center, multi-cohort, phase Ib/II clinical trial, divided into 8 cohorts according to tumor types. Cohorts 1-4 are SYHA1813 combined with different regimens, including safety run-in stage and cohort expansion stage. Cohorts 5-8 are SYHA1813 monotherapy and only include the expansion cohorts. The primary objective was to evaluate the safety and efficacy of SYHA1813 single agent or in combination with different regimens in unresectable locally advanced or metastatic solid tumors.

Detailed Description

In the safety run-in stage, the "3+3" design is used to evaluate the tolerability and safety of different dose levels combined with different regimens, and the observation period of DLT is set as the first treatment cycle. After 3 DLT-evaluable participants at each dose level completed the DLT observation period, the safety of the dose level is evaluated by an SMC consisting of the investigator and the sponsor's medical monitor. Cohorts 1-4 enter the cohort expansion stage after determining the SYHA1813 dose regimen during the safety run-in stage. Cohorts 5-8 enter the cohort expansion stage directly. In the expansion stage, cohorts 1-6 are single-arm studies, the primary endpoint is ORR as evaluated by investigator according to RECIST 1.1. Cohorts 7-8 are randomized controlled studies, the primary endpoint is PFS as evaluated by investigator according to RECIST 1.1.

Conditions

Unresectable Locally Advanced or Metastatic Solid Tumors

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

SYHA1813 single agent or in combination with different regimens

Cohorts 1-4 are SYHA1813 combined with different regimens. Cohorts 5-8 are SYHA1813 monotherapy.

Group Type: EXPERIMENTAL

SYHA1813

Intervention Type: DRUG

In accordance with the protocol

Everolimus

Intervention Type: DRUG

In accordance with the protocol

Regorafenib

Intervention Type: DRUG

In accordance with the protocol

Control group

The cohort 7 control group is Everolimus. The cohort 8 control group is Regorafenib.

Group Type: ACTIVE_COMPARATOR

SYHA1813

Intervention Type: DRUG

In accordance with the protocol

SG001

Intervention Type: DRUG

In accordance with the protocol

HB1801

Intervention Type: DRUG

In accordance with the protocol

Carboplatin

Intervention Type: DRUG

In accordance with the protocol

Cisplatin

Intervention Type: DRUG

In accordance with the protocol

Paclitaxel

Intervention Type: DRUG

In accordance with the protocol

Etoposide

Intervention Type: DRUG

In accordance with the protocol

Everolimus

Intervention Type: DRUG

In accordance with the protocol

Regorafenib

Intervention Type: DRUG

In accordance with the protocol

Interventions

SYHA1813

In accordance with the protocol

Intervention Type: DRUG

SG001

In accordance with the protocol

Intervention Type: DRUG

HB1801

In accordance with the protocol

Intervention Type: DRUG

Carboplatin

In accordance with the protocol

Intervention Type: DRUG

Cisplatin

In accordance with the protocol

Intervention Type: DRUG

Paclitaxel

In accordance with the protocol

Intervention Type: DRUG

Etoposide

In accordance with the protocol

Intervention Type: DRUG

Everolimus

In accordance with the protocol

Intervention Type: DRUG

Regorafenib

In accordance with the protocol

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

1. Aged >= 18 years;

2. Unresectable locally advanced or metastatic solid tumors confirmed by histology or cytology:

3. There is at least one measurable lesion in the baseline period (RECIST1.1);

4. ECOG PS of 0-1;

5. The expected survival time is >=3 months;

6. The organ function level and related laboratory indicators must meet the following requirements (No blood transfusion or hematopoietic stimulating factor therapy received within 14 days prior to the first medication (queue 1 to 6)/prior to randomization (queue 7 and queue 8):

ANC≥1.5×10^9/L； PLT≥100×10^9/L（Liver cancer patients PLT≥75×10^9/L）； Hb≥90 g/L； TBIL≤1.5×ULN，and for Gilbert's syndrome, liver cancer or liver metastasis patients TBIL≤3×ULN； ALT和AST≤2.5×ULN，for liver cancer or liver metastasis patients ≤5×ULN； Child-Pugh Grade A (only applicable to queue 8)； ALB≥30 g/L； Cr≤1.5×ULN，IF Cr>1.5×ULN，Ccr≥60 mL/min（Cockcroft-Gault）is required； APTT and INR≤1.5×ULN

7. The subjects must agree to take medically approved contraceptive measures for at least 6 months from the beginning of the study to the last dose of drug.

Exclusion Criteria

1. Patients who are known or suspected to be allergic to the test drug or its components;

2. Excluding the disease studied in this trial, there are other primary malignant tumors that have progressed or require treatment within the past 3 years prior to screening (except for effectively controlled skin basal cell carcinoma, cutaneous squamous cell carcinoma, superficial bladder cancer or cured breast carcinoma in situ);

3. The toxicity of previous anti-tumor treatments has not recovered (≤grode 1), except for hair loss and other adverse reactions judged by the investigator that do not affect the safety of the study medication;

4. Active leptomeningeal disease or CNS metastases that are not well controlled;

5. Uncontrollable active infections occurred within 14 days prior to the first medication (queue 1 to 6)/prior to randomization (queue 7 and queue 8), requiring systemic treatment with intravenous antibiotic infusion

6. Patients with evidence of bleeding tendency or medical history within 28 days;

7. Patients have risk factors for intestinal obstruction or intestinal perforation;

8. The subject has poorly healed wounds, ulcers or fractures;

9. Urine protein ≥ 2+, and 24-hour urine protein quantitative ≥ 1.0g/24h;

10. Patients have large pleural effusions, pericardial effusions, or abdominopelvic effusions;

11. Human immunodeficiency virus (HIV) antibody positive; active hepatitis C, with antibody positive and HCV RNA test positive; active hepatitis B, with HBsAg positive, and HBV-DNA value>500 IU/ml or 2500 copies/mL;

12. Has a history of active tuberculosis;

13. History of interstitial lung disease (except for radiotherapy-induced focal interstitial pneumonia), noninfectious pneumonitis requiring glucocorticoid therapy;

14. Received immunosuppressants such as PD-1 or PD-L1 inhibitors in the recurrent or metastatic phase (only for Cohort 1);

15. Prior treatment with a VEGFR-TKI inhibitor or other anti-angiogenic agent (except for Cohort 5,7,8);

16. Pregnant or lactating women;

17. Participants who may have poor compliance as judged by the investigator, such as a clear history of neurological or psychiatric disorders (including epilepsy or dementia), current psychiatric disorders, psychotropic drug abuse, etc.;

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Shanghai Runshi Pharmaceutical Technology Co., Ltd

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Central Contacts

Clinical Trials Information

Role: CONTACT

ctr-contact@cspc.cn

86-0311-69085587

Other Identifiers

SYHA1814-005

Identifier Type: -

Identifier Source: org_study_id