Attention Bias Modification for the Improvement of Anxiety in Adolescent and Young Adult Cancer Survivors

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

70 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-11-08

Study Completion Date

2026-01-12

Brief Summary

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This clinical trial studies how well attention bias modification (ABM) improves anxiety in adolescent and young adult (AYA) cancer survivors. Cancer-related anxiety is the most prevalent mental health problem affecting AYA cancer survivors. Cancer-related anxiety is associated with long-term negative outcomes such as poor quality of life, depression, distress, substance use, sleep problems, fatigue, and pain. ABM uses techniques to help patients change the way they react to environmental triggers that may cause a negative reaction. ABM uses brief self-guided smartphone applications. Patients complete repetitive association reaction-time tasks targeting automatic and unconscious negative attention biases to retrain attention away from perceived threat and towards a neutral or positive stimuli. Gratitude-finding and savoring activities are also provided to maintain and increase positive emotions. Using ABM plus gratitude-finding and savoring activities may improve anxiety in AYA cancer survivors.

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Detailed Description

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OUTLINE: Patients are randomized to 1 of 2 arms.

ARM I: Patients engage in ABM over 10 minutes twice a week (BIW) and respond daily to text messaging prompts activity for 4 weeks.

ARM II: Patients engage in inert attention task sessions over 10 minutes BIW for 4 weeks. Patients also receive and respond to text messaging prompts QD for 4 weeks.

After completion of study intervention, patients are followed up at 4 weeks. After completion of this 4 week follow up survey, patients are given access to all components of ABM and texts on study.

Conditions

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Childhood Hematopoietic and Lymphatic System Neoplasm Childhood Malignant Solid Neoplasm

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

SINGLE

Participants

Participants will be blind to study condition.

Study Groups

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Arm I (ABM)

Patients engage in ABM over 10 minutes BIW and respond daily to text messaging prompts for 4 weeks.

Group Type EXPERIMENTAL

Internet-Based Intervention

Intervention Type OTHER

Engage in ABM + text messaging prompts

Interview

Intervention Type OTHER

Ancillary studies

Questionnaire Administration

Intervention Type OTHER

Ancillary studies

Text Message-Based Navigation Intervention

Intervention Type OTHER

Participants will respond to daily messaging prompts.

Arm II (inert attention task)

Patients engage in inert attention task sessions over 10 minutes BIW for 4 weeks. Patients also receive and respond to text messaging prompts QD for 4 weeks. After completion of the 4 week follow up survey, patients are given access to all components of ABM and texts on study.

Group Type ACTIVE_COMPARATOR

Internet-Based Intervention

Intervention Type OTHER

Engage in inert attention task sessions

Questionnaire Administration

Intervention Type OTHER

Ancillary studies

Text Message-Based Navigation Intervention

Intervention Type OTHER

Participants will respond to daily messaging prompts.

Interventions

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Internet-Based Intervention

Engage in ABM + text messaging prompts

Intervention Type OTHER

Internet-Based Intervention

Engage in inert attention task sessions

Intervention Type OTHER

Interview

Ancillary studies

Intervention Type OTHER

Questionnaire Administration

Ancillary studies

Intervention Type OTHER

Text Message-Based Navigation Intervention

Participants will respond to daily messaging prompts.

Intervention Type OTHER

Other Intervention Names

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Automated Text Message-Based Navigation Text Message-Based Navigation

Eligibility Criteria

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Inclusion Criteria

* Age 15-29 years
* Diagnosis of cancer malignancy
* Received active/curative cancer treatment OR received/actively receiving cancer survivorship care at Seattle Children's Hospital (SCH) or other study referring site (e.g. St. Jude)
* Currently off active/curative cancer treatment
* Patient able to understand/read/write English language
* Cognitively able to participate in ABM intervention and complete surveys
* Patient has access to smartphone able to send and receive text messages
* Patient has access to computer or smartphone for Inquisit program

Exclusion Criteria

* Patients on active/curative cancer treatment
* Cognitively or physically unable to participate in ABM intervention and surveys
* Patients who cannot understand/read/write English will be excluded from the research because the ABM intervention is currently only available in English
* Furthermore, patients who do not have access to technology (smartphone/computer) will be excluded from the study as this technology is absolutely required to engage in the study intervention

Minimum Eligible Age

15 Years

Maximum Eligible Age

29 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No