Real-world Data of Paclitaxel and Ramucirumab Compared to Other Treatment Regimens in Advanced Gastric Cancer

NCT ID: NCT06666582

Last Updated: 2024-10-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

185 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-03-01

Study Completion Date

2024-01-15

Brief Summary

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Our aim was to evaluate whether second-line treatment with paclitaxel and ramucirumab was associated with improved clinical outcomes compared to other available therapies. This study involved real-world data collection, focusing on the safety and efficacy of therapeutic combinations, administered to patients with pretreated advanced gastric cancer in the Oncology Departments affiliated with the Hellenic Cooperative Oncology Group (HeCOG).

Detailed Description

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Conditions

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Gastric Cancer Stage IV Second-line Treatment Ramucirumab Paclitaxel

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

RETROSPECTIVE

Study Groups

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Patients who received paclitaxel - ramucirumab as second-line treatment

Patients with unresectable or metastatic, locally advanced adenocarcinoma of the stomach, gastroesophageal junction, or distal esophagus who had been treated at Departments of Medical Oncology affiliated with the Hellenic Cooperative Oncology Group (HeCOG). All patients had received second-line treatment for advanced disease with paclitaxel and ramucirumab, for at least two months.

Paclitaxel and ramucirumab

Intervention Type DRUG

Second-line treatment with paclitaxel/ramucirumab vs other regimens

Patients who received other regimens as second-line treatment

patients with unresectable or metastatic, locally advanced adenocarcinoma of the stomach, gastroesophageal junction, or distal esophagus who had been treated at Departments of Medical Oncology affiliated with the Hellenic Cooperative Oncology Group (HeCOG). All patients had received second-line treatment for advanced disease based on international/national guidelines, except from paclitaxel and ramucirumab. All other regimens, combinations of drugs as well as monotherapy, were accepted. Patients were included in the analysis if they have received at least two months of second-line treatment.

Paclitaxel and ramucirumab

Intervention Type DRUG

Second-line treatment with paclitaxel/ramucirumab vs other regimens

Interventions

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Paclitaxel and ramucirumab

Second-line treatment with paclitaxel/ramucirumab vs other regimens

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Patients with unresectable or metastatic, locally advanced adenocarcinoma of the stomach, gastroesophageal junction, or distal esophagus
* Treated at Departments of Medical Oncology affiliated with the Hellenic Cooperative Oncology Group (HeCOG)
* Second-line treatment for advanced disease
* Treatment for at least two months of second-line treatment.

Exclusion Criteria

* Lack of informed consent in case the patient was alive
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hellenic Cooperative Oncology Group

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Hellenic Oncology Cooperative Group

Athens, , Greece

Site Status

Countries

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Greece

Other Identifiers

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RE721

Identifier Type: -

Identifier Source: org_study_id

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