Creatine HCl and Creatine Ethyl Ester Supplementation in Perimenopausal and Menopausal Women
NCT ID: NCT06660004
Last Updated: 2025-12-16
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
36 participants
INTERVENTIONAL
2024-11-15
2025-05-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
SUPPORTIVE_CARE
DOUBLE
Study Groups
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Creatine hcl
One capsule per day of creatine hcl during breakfast
Dietary Supplement: Experimental 1 Creatine HCl
Creatine hcl
Creatine hcl 2
One capsule during breakfast and one during dinner of creatine hcl
Dietary Supplement: Experimental 2 Creatine HCl
Creatine hcl
Creatine ethyl ester
One capsule during breakfast and one during dinner of creatine ethyl ester
Dietary Supplement: Experimental 3 Creatine Ethyl ester
Creatine ethyl ester
Placebo
One capsule per day of inulin during breakfast
Dietary Supplement: Experimental 4 Placebo
Placebo
Interventions
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Dietary Supplement: Experimental 1 Creatine HCl
Creatine hcl
Dietary Supplement: Experimental 2 Creatine HCl
Creatine hcl
Dietary Supplement: Experimental 3 Creatine Ethyl ester
Creatine ethyl ester
Dietary Supplement: Experimental 4 Placebo
Placebo
Eligibility Criteria
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Inclusion Criteria
* Free of major chronic diseases or acute disorders (including AD and dementia (MMSE score \> 25 points)
* MENOPAUSAL: no menstrual cycle for consecutive 12 months (with no other obvious causes)
* PERIMENOPAUSAL: Still menstruating (regular or irregular) but have at least one of the following symptoms: (1) hot flashes, (2) sleep disturbances, (3) mood swings, and (4) concentration difficulties
* Given written informed consent
Exclusion Criteria
* Pregnancy (or planning pregnancy)
* Abnormal values for lab clinical chemistry (\> 2 SD)
* Unwillingness to return for follow-up analysis
* Participation in other clinical trials
40 Years
65 Years
FEMALE
No
Sponsors
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University of Novi Sad, Faculty of Sport and Physical Education
OTHER
Responsible Party
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Sergej Ostojic
Professor, Head of the Applied Bioenergetics Lab
Principal Investigators
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Sergej Ostojic, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
Applied BIoenergetics Lab
Locations
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FSPE Applied BIoenergetcis Lab
Novi Sad, Vojvodina, Serbia
Countries
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References
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Ostojic SM, Stea TH, Ellery SJ, Smith-Ryan AE. Association between dietary intake of creatine and female reproductive health: Evidence from NHANES 2017-2020. Food Sci Nutr. 2024 Apr 30;12(7):4893-4898. doi: 10.1002/fsn3.4135. eCollection 2024 Jul.
Korovljev D, Ostojic J, Panic J, Ranisavljev M, Todorovic N, Nedeljkovic D, Kuzmanovic J, Vranes M, Stajer V, Ostojic SM. The Effects of 8-Week Creatine Hydrochloride and Creatine Ethyl Ester Supplementation on Cognition, Clinical Outcomes, and Brain Creatine Levels in Perimenopausal and Menopausal Women (CONCRET-MENOPA): A Randomized Controlled Trial. J Am Nutr Assoc. 2025 Aug 25:1-12. doi: 10.1080/27697061.2025.2551184. Online ahead of print.
Other Identifiers
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CC-1-24
Identifier Type: -
Identifier Source: org_study_id